Sucrose 20000μM R06 exp298 [The Human Chemical-Genetic Interaction Map Project]

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====== Sucrose 20000μM R06 exp298 ======
==== Mechanism of Action ====
Disaccharide composed of glucose and fructose
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Nutrient




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Sucrose%%
    * **<color #00a2e8>Synonyms:</color>** D-(+)-Saccharose
    * **<color #00a2e8>CAS #:</color>** 57-50-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5988|5988]]
    * **<color #00a2e8>IUPAC:</color>** %%(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** CZMRCDWAGMRECN-UGDNZRGBSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 342.3
    * **<color #00a2e8>Canonical SMILES:</color>** C(C1C(C(C(C(O1)OC2(C(C(C(O2)CO)O)O)CO)O)O)O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CO)O)O)CO)O)O)O)O
    * **<color #00a2e8>Molecular Formula:</color>** C12H22O11
{{:chemogenomics:structures:chem-0185.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** S9378
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Sucrose
    * **<color #00a2e8>Min:</color>** -8.5753; **<color #00a2e8>Max:</color>** 5.4473
{{:chemogenomics:dose_response:dr_243.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 06
    * **<color #00a2e8>Dose</color>**: 20000µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.6
    * **<color #00a2e8>Numbers of reads</color>**: 8646969


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Sucrose_20000uM_Round-6_exp298.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Sucrose 20000μM R06 exp298'>
{{:chemogenomics:cranks_plots:exp298.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:R:RSRC2|RSRC2]]|-4.43|0.17|
|[[:human_genes:D:DGKK|DGKK]]|-2.50|0.17|
|[[:human_genes:M:MNS1|MNS1]]|-2.37|0.60|
|[[:human_genes:C:CBFB|CBFB]]|-2.36|0.29|
|[[:human_genes:W:WBSCR16|WBSCR16]]|-2.28|0.69|
|[[:human_genes:C:CERS2|CERS2]]|-2.26|0.31|
|[[:human_genes:S:SEC24B|SEC24B]]|-2.26|0.31|
|[[:human_genes:T:TRO|TRO]]|-2.25|0.46|
|[[:human_genes:N:NQO1|NQO1]]|-2.23|0.46|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.19|0.60|
|[[:human_genes:V:VPS25|VPS25]]|-2.13|0.73|
|[[:human_genes:R:RAB18|RAB18]]|-2.11|0.46|
|[[:human_genes:M:MOG|MOG]]|-2.10|0.58|
|[[:human_genes:T:TLE6|TLE6]]|-2.09|0.46|
|[[:human_genes:F:FOXP1|FOXP1]]|-2.04|0.55|
|[[:human_genes:E:EXOC8|EXOC8]]|-2.04|0.60|
|[[:human_genes:S:SOD1|SOD1]]|-2.03|0.70|
|[[:human_genes:G:GFPT1|GFPT1]]|-2.03|0.69|
|[[:human_genes:M:MOGAT1|MOGAT1]]|-2.02|0.56|
|[[:human_genes:B:BEND5|BEND5]]|-2.00|0.66|
|[[:human_genes:T:TCF4|TCF4]]|-1.99|0.58|
|[[:human_genes:F:FBXW7|FBXW7]]|-1.97|0.68|
|[[:human_genes:G:GET4|GET4]]|-1.96|0.68|
|[[:human_genes:S:SNX27|SNX27]]|-1.96|0.60|
|[[:human_genes:P:PTMS|PTMS]]|-1.93|0.68|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-1.91|0.62|
|[[:human_genes:N:NDUFB3|NDUFB3]]|-1.91|0.68|
|[[:human_genes:C:CD81|CD81]]|-1.90|0.68|
|[[:human_genes:O:OR8J3|OR8J3]]|-1.88|0.68|
|[[:human_genes:S:SORCS1|SORCS1]]|-1.88|0.68|
|[[:human_genes:S:SYNPR|SYNPR]]|1.88|0.73|
|[[:human_genes:S:SLC25A18|SLC25A18]]|1.90|0.73|
|[[:human_genes:C:COX7A2|COX7A2]]|1.92|0.73|
|[[:human_genes:S:SAFB|SAFB]]|1.93|0.73|
|[[:human_genes:H:HEATR5B|HEATR5B]]|1.93|0.75|
|[[:human_genes:O:OVOL3|OVOL3]]|1.96|0.70|
|[[:human_genes:G:GZF1|GZF1]]|1.98|0.75|
|[[:human_genes:C:CDC6|CDC6]]|1.99|0.73|
|[[:human_genes:T:THOC2|THOC2]]|1.99|0.87|
|[[:human_genes:D:DZANK1|DZANK1]]|2.01|0.63|
|[[:human_genes:Z:ZHX1|ZHX1]]|2.02|0.73|
|[[:human_genes:C:CTSC|CTSC]]|2.04|0.63|
|[[:human_genes:I:INPP4A|INPP4A]]|2.06|0.63|
|[[:human_genes:E:EEF1A1|EEF1A1]]|2.07|0.75|
|[[:human_genes:C:CBLB|CBLB]]|2.07|0.75|
|[[:human_genes:K:KRTAP16-1|KRTAP16-1]]|2.07|0.63|
|[[:human_genes:Z:ZNF777|ZNF777]]|2.10|0.67|
|[[:human_genes:P:PES1|PES1]]|2.13|0.83|
|[[:human_genes:M:MFGE8|MFGE8]]|2.13|0.63|
|[[:human_genes:A:AURKA|AURKA]]|2.16|0.75|
|[[:human_genes:Y:YTHDC1|YTHDC1]]|2.18|0.75|
|[[:human_genes:X:XYLT2|XYLT2]]|2.27|0.62|
|[[:human_genes:Z:ZNF202|ZNF202]]|2.28|0.62|
|[[:human_genes:N:NUP88|NUP88]]|2.35|0.48|
|[[:human_genes:P:PSMC4|PSMC4]]|2.37|0.75|
|[[:human_genes:D:DDX21|DDX21]]|2.44|0.79|
|[[:human_genes:P:PMPCA|PMPCA]]|2.57|0.75|
|[[:human_genes:E:EIF5|EIF5]]|2.58|0.62|
|[[:human_genes:N:NPIPB4|NPIPB4]]|3.00|0.48|
|[[:human_genes:N:NPIPB3|NPIPB3]]|3.81|0.56|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>