VER-155008 3.9μM R06 exp301 [The Human Chemical-Genetic Interaction Map Project]

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====== VER-155008 3.9μM R06 exp301 ======
==== Mechanism of Action ====
Inhibits HSP70
  * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / Chaperone Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1134156-31-2
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/25195348|25195348]]
    * **<color #00a2e8>IUPAC:</color>** %%4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethyl]benzonitrile%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** ZXGGCBQORXDVTE-UMCMBGNQSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 556.4
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=CC=C1COCC2C(C(C(O2)N3C4=NC=NC(=C4N=C3NCC5=CC(=C(C=C5)Cl)Cl)N)O)O)C#N
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC(=CC=C1COC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3NCC5=CC(=C(C=C5)Cl)Cl)N)O)O)C#N
    * **<color #00a2e8>Molecular Formula:</color>** C25H23Cl2N7O4
{{:chemogenomics:structures:chem-0188.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Cayman Chemical
    * **<color #00a2e8>Catalog #:</color>** 17257
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C25H23Cl2N7O4 556.12613; found 556.12669
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** VER-155008
    * **<color #00a2e8>Min:</color>** -10.6600; **<color #00a2e8>Max:</color>** 98.1898
{{:chemogenomics:dose_response:dr_279.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |2.2255    |
| IC30  |3.8995    |
| IC40  |6.1756    |
| IC50  |9.4171    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 06
    * **<color #00a2e8>Dose</color>**: 3.9µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.3
    * **<color #00a2e8>Numbers of reads</color>**: 23838336


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/23|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/VER-155008_3.9uM_Round-6_exp301.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='VER-155008 3.9μM R06 exp301'>
{{:chemogenomics:cranks_plots:exp301.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.78|0.07|
|[[:human_genes:P:PPIL1|PPIL1]]|-2.73|0.09|
|[[:human_genes:E:ELF2|ELF2]]|-2.66|0.07|
|[[:human_genes:G:GMPPB|GMPPB]]|-2.61|0.46|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.53|0.21|
|[[:human_genes:W:WDR20|WDR20]]|-2.41|0.17|
|[[:human_genes:M:MYBPC3|MYBPC3]]|-2.40|0.21|
|[[:human_genes:A:AIFM3|AIFM3]]|-2.35|0.19|
|[[:human_genes:K:KRTAP19-1|KRTAP19-1]]|-2.30|0.21|
|[[:human_genes:G:GPNMB|GPNMB]]|-2.26|0.31|
|[[:human_genes:S:SHOC2|SHOC2]]|-2.24|0.32|
|[[:human_genes:B:BRD3|BRD3]]|-2.23|0.21|
|[[:human_genes:Z:ZW10|ZW10]]|-2.21|0.21|
|[[:human_genes:D:DYNC1H1|DYNC1H1]]|-2.19|0.67|
|[[:human_genes:C:CENPN|CENPN]]|-2.08|0.46|
|[[:human_genes:M:MOCS3|MOCS3]]|-2.08|0.46|
|[[:human_genes:W:WDR48|WDR48]]|-2.07|0.37|
|[[:human_genes:E:EMC10|EMC10]]|-2.07|0.46|
|[[:human_genes:Z:ZEB2|ZEB2]]|-2.06|0.48|
|[[:human_genes:H:HSPA4|HSPA4]]|-2.05|0.48|
|[[:human_genes:U:UBA5|UBA5]]|-2.04|0.41|
|[[:human_genes:W:WDR55|WDR55]]|-2.03|0.65|
|[[:human_genes:X:XRCC5|XRCC5]]|-2.01|0.53|
|[[:human_genes:Z:ZC3H14|ZC3H14]]|-2.01|0.48|
|[[:human_genes:C:CMTM7|CMTM7]]|-1.99|0.46|
|[[:human_genes:C:CFAP45|CFAP45]]|-1.98|0.71|
|[[:human_genes:P:PHC1|PHC1]]|-1.97|0.46|
|[[:human_genes:C:CANX|CANX]]|-1.96|0.48|
|[[:human_genes:V:VPS25|VPS25]]|-1.95|0.72|
|[[:human_genes:N:NCF4|NCF4]]|-1.94|0.48|
|[[:human_genes:P:PAPSS1|PAPSS1]]|2.38|0.06|
|[[:human_genes:S:STK11|STK11]]|2.40|0.05|
|[[:human_genes:M:MBTPS2|MBTPS2]]|2.40|0.03|
|[[:human_genes:D:DSCC1|DSCC1]]|2.40|0.03|
|[[:human_genes:D:DHX35|DHX35]]|2.42|0.03|
|[[:human_genes:K:KDM1A|KDM1A]]|2.43|0.08|
|[[:human_genes:C:CPNE2|CPNE2]]|2.43|0.03|
|[[:human_genes:P:PAFAH1B1|PAFAH1B1]]|2.49|0.32|
|[[:human_genes:S:SH3GL1|SH3GL1]]|2.49|0.06|
|[[:human_genes:R:RFC1|RFC1]]|2.49|0.23|
|[[:human_genes:L:LRRC63|LRRC63]]|2.51|0.31|
|[[:human_genes:G:GNA13|GNA13]]|2.52|0.02|
|[[:human_genes:M:MCM9|MCM9]]|2.54|0.04|
|[[:human_genes:R:RGP1|RGP1]]|2.58|0.05|
|[[:human_genes:U:UBE2N|UBE2N]]|2.58|0.03|
|[[:human_genes:C:COX19|COX19]]|2.58|0.02|
|[[:human_genes:P:PRKAG1|PRKAG1]]|2.59|0.05|
|[[:human_genes:S:SLC25A51|SLC25A51]]|2.59|0.02|
|[[:human_genes:C:CLPP|CLPP]]|2.63|0.03|
|[[:human_genes:A:ARL1|ARL1]]|2.64|0.01|
|[[:human_genes:A:AP2S1|AP2S1]]|2.97|<0.01|
|[[:human_genes:K:KIAA1432|KIAA1432]]|3.02|<0.01|
|[[:human_genes:P:PRKAA1|PRKAA1]]|3.17|<0.01|
|[[:human_genes:C:C19orf24|C19orf24]]|3.18|<0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.21|<0.01|
|[[:human_genes:I:IKZF1|IKZF1]]|3.26|<0.01|
|[[:human_genes:A:AP1M1|AP1M1]]|4.15|<0.01|
|[[:human_genes:I:IKZF2|IKZF2]]|4.16|<0.01|
|[[:human_genes:W:WDR11|WDR11]]|4.72|<0.01|
|[[:human_genes:K:KCTD5|KCTD5]]|4.85|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|0.057|<button type="primary" size="small" modal="1">View</button>|
</modal>


<modal id="1" size="lg" title="Arsenate 40μM R06 exp264  vs  VER-155008 3.9μM R06 exp301">
{{:chemogenomics:comparison_plots:exp264_vs_exp301.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>