Dimethyloxaloylglycine 11μM R07 exp314 [The Human Chemical-Genetic Interaction Map Project]

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====== Dimethyloxaloylglycine 11μM R07 exp314 ======
==== Mechanism of Action ====
Prolylhydroxylase inhibitor, induces HIF-1α accumulation
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolic Enzyme Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / Other inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Dimethyloxalylglycine%%
    * **<color #00a2e8>Synonyms:</color>** Dimethyloxallyl Glycine
    * **<color #00a2e8>CAS #:</color>** 89464-63-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/560326|560326]]
    * **<color #00a2e8>IUPAC:</color>** %%methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
    * **<color #00a2e8>INCHI Key:</color>** BNJOZDZCRHCODO-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 175.14
    * **<color #00a2e8>Canonical SMILES:</color>** COC(=O)CNC(=O)C(=O)OC
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C6H9NO5
{{:chemogenomics:structures:chem-0134.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** D476325
    * **<color #00a2e8>Lot #:</color>** 5-RUS-16-1
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C6H9NO5 176.05535; found 176.05545
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** DMOG
    * **<color #00a2e8>Min:</color>** -16.4864; **<color #00a2e8>Max:</color>** 89.0929
{{:chemogenomics:dose_response:dr_384.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |6.0680    |
| IC30  |8.8278    |
| IC40  |12.6233    |
| IC50  |18.2304    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 11µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.0
    * **<color #00a2e8>Numbers of reads</color>**: 21046274


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Dimethyloxaloylglycine_11uM_Round-7_exp314.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Dimethyloxaloylglycine 11μM R07 exp314'>
{{:chemogenomics:cranks_plots:exp314.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:E:EGLN1|EGLN1]]|-2.85|0.05|
|[[:human_genes:U:UHRF1|UHRF1]]|-2.68|0.10|
|[[:human_genes:V:VEZT|VEZT]]|-2.51|0.10|
|[[:human_genes:A:ABCC4|ABCC4]]|-2.48|0.10|
|[[:human_genes:T:TRIM33|TRIM33]]|-2.34|0.19|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.27|0.24|
|[[:human_genes:P:PAX3|PAX3]]|-2.18|0.54|
|[[:human_genes:B:BZW2|BZW2]]|-2.16|0.39|
|[[:human_genes:B:BUD13|BUD13]]|-2.15|0.54|
|[[:human_genes:N:NWD1|NWD1]]|-2.14|0.54|
|[[:human_genes:K:KRTAP10-10|KRTAP10-10]]|-2.12|0.54|
|[[:human_genes:G:GMPPB|GMPPB]]|-2.07|0.75|
|[[:human_genes:T:TACR3|TACR3]]|-2.05|0.54|
|[[:human_genes:T:TAF1A|TAF1A]]|-2.01|0.73|
|[[:human_genes:M:MRPS33|MRPS33]]|-2.01|0.62|
|[[:human_genes:E:EIF4G3|EIF4G3]]|-1.98|0.66|
|[[:human_genes:T:TMIE|TMIE]]|-1.98|0.54|
|[[:human_genes:C:CEP95|CEP95]]|-1.97|0.54|
|[[:human_genes:C:CUL2|CUL2]]|-1.97|0.54|
|[[:human_genes:O:OR6C1|OR6C1]]|-1.95|0.73|
|[[:human_genes:O:OR5I1|OR5I1]]|-1.94|0.54|
|[[:human_genes:S:SH2D3C|SH2D3C]]|-1.94|0.54|
|[[:human_genes:H:HMGB2|HMGB2]]|-1.94|0.54|
|[[:human_genes:H:HNRNPM|HNRNPM]]|-1.92|0.73|
|[[:human_genes:S:SLC6A15|SLC6A15]]|-1.88|0.65|
|[[:human_genes:C:CEP63|CEP63]]|-1.88|0.73|
|[[:human_genes:A:ATP6V1D|ATP6V1D]]|-1.87|0.73|
|[[:human_genes:A:ATPIF1|ATPIF1]]|-1.87|0.73|
|[[:human_genes:Z:ZSCAN12|ZSCAN12]]|-1.84|0.80|
|[[:human_genes:K:KDELC1|KDELC1]]|-1.82|0.73|
|[[:human_genes:N:NPIPB6|NPIPB6]]|1.88|0.72|
|[[:human_genes:A:ANO6|ANO6]]|1.89|0.65|
|[[:human_genes:K:KLRG2|KLRG2]]|1.91|0.65|
|[[:human_genes:S:SF1|SF1]]|1.93|0.65|
|[[:human_genes:M:MDH1|MDH1]]|1.94|0.65|
|[[:human_genes:N:NOTCH4|NOTCH4]]|1.95|0.65|
|[[:human_genes:C:CLP1|CLP1]]|1.95|0.65|
|[[:human_genes:S:SLC16A7|SLC16A7]]|1.96|0.65|
|[[:human_genes:C:CCDC140|CCDC140]]|1.96|0.65|
|[[:human_genes:R:RPL15|RPL15]]|1.97|0.65|
|[[:human_genes:N:NUDCD1|NUDCD1]]|1.97|0.65|
|[[:human_genes:A:ALX1|ALX1]]|1.97|0.65|
|[[:human_genes:P:POU2AF1|POU2AF1]]|1.99|0.65|
|[[:human_genes:R:RPL10A|RPL10A]]|2.00|0.72|
|[[:human_genes:D:DACT3|DACT3]]|2.00|0.65|
|[[:human_genes:H:HLA-DQA1|HLA-DQA1]]|2.03|0.65|
|[[:human_genes:U:USP17L19|USP17L19]]|2.04|0.73|
|[[:human_genes:P:PLK4|PLK4]]|2.04|0.72|
|[[:human_genes:I:IL31RA|IL31RA]]|2.06|0.65|
|[[:human_genes:R:RPL22|RPL22]]|2.06|0.65|
|[[:human_genes:R:RPL35A|RPL35A]]|2.09|0.78|
|[[:human_genes:U:UPK3BL|UPK3BL]]|2.14|0.65|
|[[:human_genes:C:COPG1|COPG1]]|2.14|0.65|
|[[:human_genes:Z:ZNF101|ZNF101]]|2.17|0.65|
|[[:human_genes:P:PSMD3|PSMD3]]|2.22|0.66|
|[[:human_genes:L:LRRC30|LRRC30]]|2.24|0.65|
|[[:human_genes:R:RPL30|RPL30]]|2.25|0.72|
|[[:human_genes:T:TSHZ3|TSHZ3]]|2.28|0.65|
|[[:human_genes:L:LOC391322|LOC391322]]|2.54|0.72|
|[[:human_genes:P:POLE|POLE]]|3.00|0.52|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|cytosolic large ribosomal subunit|65.02|RPL30,RPL35A,RPL22,RPL10A,RPL15,RPL37|
|cytosolic ribosome|31.88|RPL30,RPL35A,RPL22,RPL10A,RPL15,RPL37|
|large ribosomal subunit|30.70|RPL30,RPL35A,RPL22,RPL10A,RPL15,RPL37|
|cytoplasmic translation|29.61|RPL30,RPL35A,RPL22,RPL10A,RPL15,RPL37|
|structural constituent of ribosome|22.11|RPL30,RPL35A,RPL22,RPL10A,RPL15,RPL37|
|ribosomal subunit|19.06|RPL30,RPL35A,RPL22,RPL10A,RPL15,RPL37|
|ribosome|17.75|RPL30,RPL35A,RPL22,RPL10A,RPL15,SF1,RPL37|
|ribonucleoprotein complex|6.39|RPL30,RPL35A,RPL22,RPL10A,RPL15,SF1,RBMXL3,RPL37|
</modal>