ABT-702 5μM R07 exp318 [The Human Chemical-Genetic Interaction Map Project]

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====== ABT-702 5μM R07 exp318 ======
==== Mechanism of Action ====
Inhibits adenosine kinase (ADK)
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolic Enzyme Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Adenosine Kinase Inhibitor%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1188890-28-9
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/16760265|16760265]]
    * **<color #00a2e8>IUPAC:</color>** %%5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C22H19BrN6O.2ClH/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29;;/h1-5,10-13H,6-9H2,(H2,24,26,27,28);2*1H
    * **<color #00a2e8>INCHI Key:</color>** OOXNYFKPOPJIOT-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 536.2
    * **<color #00a2e8>Canonical SMILES:</color>** C1COCCN1C2=NC=C(C=C2)C3=NC4=NC=NC(=C4C(=C3)C5=CC(=CC=C5)Br)N.Cl.Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C22H21BrCl2N6O
{{:chemogenomics:structures:chem-0155.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Tocris Bioscience
    * **<color #00a2e8>Catalog #:</color>** 2372
    * **<color #00a2e8>Lot #:</color>** 1B/195137
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C22H19BrN6O 463.08765; found 463.08744
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** ABT-702
    * **<color #00a2e8>Min:</color>** -4.4284; **<color #00a2e8>Max:</color>** 61.7948
{{:chemogenomics:dose_response:dr_414.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |21.2789    |
| IC30  |28.6144    |
| IC40  |38.7761    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 5µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.3
    * **<color #00a2e8>Numbers of reads</color>**: 24040743


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/ABT-702_5uM_Round-7_exp318.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='ABT-702 5μM R07 exp318'>
{{:chemogenomics:cranks_plots:exp318.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SLC5A3|SLC5A3]]|-3.30|<0.01|
|[[:human_genes:R:RNASEH2A|RNASEH2A]]|-2.61|0.16|
|[[:human_genes:N:NDUFB3|NDUFB3]]|-2.52|0.16|
|[[:human_genes:A:ACSL3|ACSL3]]|-2.49|0.19|
|[[:human_genes:D:DKC1|DKC1]]|-2.47|0.82|
|[[:human_genes:F:FAM183A|FAM183A]]|-2.39|0.18|
|[[:human_genes:A:ATP5A1|ATP5A1]]|-2.15|0.49|
|[[:human_genes:C:CEP68|CEP68]]|-2.13|0.79|
|[[:human_genes:Z:ZSCAN12|ZSCAN12]]|-2.09|0.82|
|[[:human_genes:F:FOXP4|FOXP4]]|-2.07|0.79|
|[[:human_genes:R:RSRC2|RSRC2]]|-2.03|0.89|
|[[:human_genes:T:TRIP12|TRIP12]]|-2.00|0.79|
|[[:human_genes:W:WDSUB1|WDSUB1]]|-2.00|0.79|
|[[:human_genes:C:COX17|COX17]]|-1.99|0.82|
|[[:human_genes:C:CEPT1|CEPT1]]|-1.99|0.79|
|[[:human_genes:C:CUL2|CUL2]]|-1.96|0.79|
|[[:human_genes:C:CCDC23|CCDC23]]|-1.95|0.79|
|[[:human_genes:E:EPN3|EPN3]]|-1.95|0.79|
|[[:human_genes:W:WBSCR16|WBSCR16]]|-1.95|0.82|
|[[:human_genes:A:ABHD3|ABHD3]]|-1.94|0.79|
|[[:human_genes:G:GPR84|GPR84]]|-1.92|0.79|
|[[:human_genes:G:GMPPB|GMPPB]]|-1.92|0.82|
|[[:human_genes:M:MMP13|MMP13]]|-1.91|0.79|
|[[:human_genes:U:UBXN1|UBXN1]]|-1.90|0.81|
|[[:human_genes:T:TMEM219|TMEM219]]|-1.89|0.81|
|[[:human_genes:P:PHTF2|PHTF2]]|-1.88|0.79|
|[[:human_genes:S:ST6GAL2|ST6GAL2]]|-1.87|0.82|
|[[:human_genes:C:CAMLG|CAMLG]]|-1.85|0.79|
|[[:human_genes:C:CLEC18C|CLEC18C]]|-1.84|0.79|
|[[:human_genes:P:PCDHA12|PCDHA12]]|-1.83|0.79|
|[[:human_genes:Z:ZNF335|ZNF335]]|2.00|0.57|
|[[:human_genes:L:LRRC47|LRRC47]]|2.03|0.46|
|[[:human_genes:K:KRT82|KRT82]]|2.03|0.46|
|[[:human_genes:B:BRD4|BRD4]]|2.04|0.50|
|[[:human_genes:G:GAP43|GAP43]]|2.04|0.46|
|[[:human_genes:N:NOTCH2|NOTCH2]]|2.04|0.49|
|[[:human_genes:R:RHOF|RHOF]]|2.05|0.46|
|[[:human_genes:D:DSC3|DSC3]]|2.06|0.46|
|[[:human_genes:I:ISY1-RAB43|ISY1-RAB43]]|2.07|0.56|
|[[:human_genes:R:RPL36A-HNRNPH2|RPL36A-HNRNPH2]]|2.11|0.69|
|[[:human_genes:R:RELN|RELN]]|2.11|0.46|
|[[:human_genes:K:KRTAP4-5|KRTAP4-5]]|2.14|0.46|
|[[:human_genes:D:DDX18|DDX18]]|2.20|0.49|
|[[:human_genes:P:PLRG1|PLRG1]]|2.21|0.46|
|[[:human_genes:G:GPC5|GPC5]]|2.22|0.46|
|[[:human_genes:M:MSI2|MSI2]]|2.23|0.46|
|[[:human_genes:W:WBSCR22|WBSCR22]]|2.23|0.50|
|[[:human_genes:P:PSMB4|PSMB4]]|2.23|0.46|
|[[:human_genes:U:USP17L19|USP17L19]]|2.24|0.56|
|[[:human_genes:U:UTP20|UTP20]]|2.27|0.46|
|[[:human_genes:S:SLIT3|SLIT3]]|2.30|0.42|
|[[:human_genes:I:ILF3|ILF3]]|2.32|0.49|
|[[:human_genes:I:ISY1|ISY1]]|2.38|0.49|
|[[:human_genes:S:SF3A1|SF3A1]]|2.41|0.46|
|[[:human_genes:R:RSPO3|RSPO3]]|2.48|0.20|
|[[:human_genes:R:RPS8|RPS8]]|2.58|0.46|
|[[:human_genes:G:GYPE|GYPE]]|2.59|0.46|
|[[:human_genes:C:C18orf32|C18orf32]]|2.60|0.49|
|[[:human_genes:R:RPL37A|RPL37A]]|2.63|0.46|
|[[:human_genes:M:MARCO|MARCO]]|2.72|0.20|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|0.059|<button type="primary" size="small" modal="1">View</button>|
</modal>


<modal id="1" size="lg" title="ABT-702 5μM R07 exp318  vs  CCT251545 0.2μM R06 exp271">
{{:chemogenomics:comparison_plots:exp271_vs_exp318.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|ribonucleoprotein complex biogenesis|10.26|RPS8,SF3A1,ISY1,UTP20,BUD23,DDX18,YTHDC1,RPS16|
|ribonucleoprotein complex|7.19|RPL37A,RPS8,SF3A1,ISY1,ILF3,UTP20,MSI2,PLRG1,RPS16|
</modal>