Rotenone 20μM R00 exp34 [The Human Chemical-Genetic Interaction Map Project]

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====== Rotenone 20μM R00 exp34 ======
==== Mechanism of Action ====
Inhibits complex I, blocks electron transfer from iron-sulfur centers to ubiquinone, generates ROS, also inhibits microtubule assembly
  * **<color #00a2e8>Class / Subclass 1:</color>** Organelle Function / Mitochondrial Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Cell Cycle / Microtubule Poison



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Rotenone%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 83-79-4
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/6758|6758]]
    * **<color #00a2e8>IUPAC:</color>** %%(1S,6R,13S)-16,17-dimethoxy-6-prop-1-en-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** JUVIOZPCNVVQFO-HBGVWJBISA-N
    * **<color #00a2e8>Molecular Weight:</color>** 394.4
    * **<color #00a2e8>Canonical SMILES:</color>** CC(=C)C1CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC
    * **<color #00a2e8>Isomeric SMILES:</color>** CC(=C)[C@H]1CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC
    * **<color #00a2e8>Molecular Formula:</color>** C23H22O6
{{:chemogenomics:structures:chem-0018.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** R8875
    * **<color #00a2e8>Lot #:</color>** SLBG7568V
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C23H22O6 395.14891; found 395.15075
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Rotenone
    * **<color #00a2e8>Min:</color>** 11.0154; **<color #00a2e8>Max:</color>** 87.2842
{{:chemogenomics:dose_response:dr_275.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0123    |
| IC30  |0.0322    |
| IC40  |0.0711    |
| IC50  |0.1468    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 00
    * **<color #00a2e8>Dose</color>**: 20µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.1
    * **<color #00a2e8>Numbers of reads</color>**: 9667752


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|15/52|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Rotenone_20uM_Round-0_exp34.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Rotenone 20μM R00 exp34'>
{{:chemogenomics:cranks_plots:exp34.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:G:GOLGA6L1|GOLGA6L1]]|-3.57|0.05|
|[[:human_genes:D:DDX3X|DDX3X]]|-3.35|<0.01|
|[[:human_genes:M:MPHOSPH10|MPHOSPH10]]|-3.07|0.03|
|[[:human_genes:C:COX7A2L|COX7A2L]]|-3.06|<0.01|
|[[:human_genes:C:C6orf118|C6orf118]]|-2.99|0.02|
|[[:human_genes:P:POLR2J3|POLR2J3]]|-2.88|0.10|
|[[:human_genes:T:TAF1|TAF1]]|-2.83|0.03|
|[[:human_genes:P:PSMA3|PSMA3]]|-2.77|0.12|
|[[:human_genes:P:POLR2I|POLR2I]]|-2.69|0.03|
|[[:human_genes:S:SIN3A|SIN3A]]|-2.63|0.03|
|[[:human_genes:B:BRD2|BRD2]]|-2.62|0.03|
|[[:human_genes:E:EIF5B|EIF5B]]|-2.60|0.10|
|[[:human_genes:A:ATP6V1A|ATP6V1A]]|-2.58|0.04|
|[[:human_genes:S:SYS1|SYS1]]|-2.57|0.03|
|[[:human_genes:T:TFPT|TFPT]]|-2.53|0.05|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.51|0.03|
|[[:human_genes:P:PLEKHJ1|PLEKHJ1]]|-2.50|0.03|
|[[:human_genes:H:HK1|HK1]]|-2.48|0.06|
|[[:human_genes:R:RAD54L2|RAD54L2]]|-2.47|0.03|
|[[:human_genes:M:MSI2|MSI2]]|-2.47|0.03|
|[[:human_genes:R:RPL34|RPL34]]|-2.46|0.27|
|[[:human_genes:R:RPL35|RPL35]]|-2.44|0.07|
|[[:human_genes:C:CANX|CANX]]|-2.44|0.10|
|[[:human_genes:E:EGR2|EGR2]]|-2.40|0.16|
|[[:human_genes:E:ERCC2|ERCC2]]|-2.39|0.11|
|[[:human_genes:T:TAF7|TAF7]]|-2.38|0.08|
|[[:human_genes:C:CDK7|CDK7]]|-2.37|0.08|
|[[:human_genes:A:ARID4B|ARID4B]]|-2.35|0.08|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|-2.33|0.06|
|[[:human_genes:W:WDR75|WDR75]]|-2.33|0.22|
|[[:human_genes:T:TIMM23B|TIMM23B]]|2.64|0.09|
|[[:human_genes:I:ID3|ID3]]|2.66|<0.01|
|[[:human_genes:K:KCTD5|KCTD5]]|2.68|<0.01|
|[[:human_genes:S:SEC63|SEC63]]|2.69|0.01|
|[[:human_genes:E:EPC1|EPC1]]|2.76|<0.01|
|[[:human_genes:N:NSD1|NSD1]]|2.79|0.03|
|[[:human_genes:C:CASP9|CASP9]]|2.87|<0.01|
|[[:human_genes:C:CRLS1|CRLS1]]|2.89|<0.01|
|[[:human_genes:N:NUDT21|NUDT21]]|2.92|<0.01|
|[[:human_genes:T:TRIAP1|TRIAP1]]|2.96|<0.01|
|[[:human_genes:H:HMGB2|HMGB2]]|2.97|<0.01|
|[[:human_genes:H:HARS|HARS]]|3.05|0.03|
|[[:human_genes:P:PMPCB|PMPCB]]|3.11|<0.01|
|[[:human_genes:Z:ZNF608|ZNF608]]|3.15|<0.01|
|[[:human_genes:U:UBQLN1|UBQLN1]]|3.19|<0.01|
|[[:human_genes:M:MTOR|MTOR]]|3.25|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|3.29|<0.01|
|[[:human_genes:M:MEAF6|MEAF6]]|3.38|<0.01|
|[[:human_genes:A:ATP2B1|ATP2B1]]|3.40|<0.01|
|[[:human_genes:R:RPTOR|RPTOR]]|3.53|<0.01|
|[[:human_genes:C:CSNK2B|CSNK2B]]|3.63|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|3.95|<0.01|
|[[:human_genes:N:NXT1|NXT1]]|4.12|<0.01|
|[[:human_genes:P:PLAA|PLAA]]|4.12|<0.01|
|[[:human_genes:H:HCCS|HCCS]]|4.32|<0.01|
|[[:human_genes:T:TLE4|TLE4]]|4.52|<0.01|
|[[:human_genes:C:CYCS|CYCS]]|4.57|<0.01|
|[[:human_genes:E:ENY2|ENY2]]|4.72|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|4.86|<0.01|
|[[:human_genes:A:APAF1|APAF1]]|5.96|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.093|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.091|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.083|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.07|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|0.069|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.061|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.056|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.193|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.158|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.158|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.151|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.116|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.107|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.107|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.101|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.099|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.099|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.098|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.087|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|0.086|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp17|DABN 20μM R00 exp17]]|0.079|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.078|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.072|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|0.072|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.071|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.066|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.062|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.062|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|0.061|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.061|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.055|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.055|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.054|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.052|<button type="primary" size="small" modal="34">View</button>|
</modal>


<modal id="1" size="lg" title="Rotenone 20μM R00 exp34  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp34_vs_exp531.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Rotenone 20μM R00 exp34  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp34.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Rotenone 20μM R00 exp34  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp34_vs_exp443.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Rotenone 20μM R00 exp34  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp34_vs_exp524.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Rotenone 20μM R00 exp34  vs  Rotenone 2μM R00 exp33">
{{:chemogenomics:comparison_plots:exp33_vs_exp34.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Rotenone 20μM R00 exp34  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp34_vs_exp527.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Rotenone 20μM R00 exp34  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp34_vs_exp85.png?nolink |}}
</modal>

<modal id="8" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp2_vs_exp34.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp3_vs_exp34.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Etoposide 1μM R00 exp19  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp19_vs_exp34.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp28_vs_exp34.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp199_vs_exp34.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Benzoate 20000μM R08 exp456  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp456.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp503.png?nolink |}}
</modal>

<modal id="15" size="lg" title="CI-1040 9.5μM R08 exp472  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp472.png?nolink |}}
</modal>

<modal id="16" size="lg" title="RO-3307 4.7μM R02 exp80  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp80.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Bleomycin 5μM R08 exp459  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp459.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp478.png?nolink |}}
</modal>

<modal id="19" size="lg" title="MLN-4924 2μM R00 exp22  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp22_vs_exp34.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Bortezomib 0.05μM R00 exp7  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp7.png?nolink |}}
</modal>

<modal id="21" size="lg" title="DABN 20μM R00 exp17  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp17_vs_exp34.png?nolink |}}
</modal>

<modal id="22" size="lg" title="AICAR 240μM R05 exp211  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp211_vs_exp34.png?nolink |}}
</modal>

<modal id="23" size="lg" title="JQ1 0.8μM R08 exp435  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp435.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Oligomycin-A 20μM R00 exp26  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp26_vs_exp34.png?nolink |}}
</modal>

<modal id="25" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp259_vs_exp34.png?nolink |}}
</modal>

<modal id="26" size="lg" title="PU-H71 1μM R08 exp515  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp515.png?nolink |}}
</modal>

<modal id="27" size="lg" title="MS023 7μM R03 exp135  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp135_vs_exp34.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp440.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Etoposide 10μM R00 exp20  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp20_vs_exp34.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp488.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Olaparib 4μM R08 exp512  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp512.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp357.png?nolink |}}
</modal>

<modal id="33" size="lg" title="42°C R08 exp539  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp539.png?nolink |}}
</modal>

<modal id="34" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp489.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|CAK-ERCC2 complex|409.41|ERCC2,CDK7|
|transcription factor TFIID complex|54.19|TAF1,ERCC2,TAF7|
|RNA polymerase II, holoenzyme|51.18|POLR2J3,TAF1,POLR2I,ERCC2,TAF7,CDK7|
|nuclear DNA-directed RNA polymerase complex|39.20|POLR2J3,TAF1,POLR2I,ERCC2,TAF7,CDK7|
|DNA-directed RNA polymerase complex|37.99|POLR2J3,TAF1,POLR2I,ERCC2,TAF7,CDK7|
|RNA polymerase complex|37.22|POLR2J3,TAF1,POLR2I,ERCC2,TAF7,CDK7|
|transcription initiation at RNA polymerase II promoter|35.09|TAF1,POLR2I,TAF7,CDK7|
|DNA-templated transcription initiation|24.08|TAF1,POLR2I,TAF7,CDK7|
|ATP-dependent activity, acting on DNA|21.36|DDX3X,RAD54L2,ERCC2,CDK7|
|transferase complex, transferring phosphorus-containing groups|15.19|POLR2J3,TAF1,POLR2I,ERCC2,TAF7,CDK7,ZBTB7A|
|transcription by RNA polymerase II|12.68|POLR2J3,TAF1,POLR2I,ERCC2,TAF7,CDK7,ARID4B|
|DNA-templated transcription|10.32|POLR2J3,TAF1,POLR2I,ERCC2,TAF7,CDK7,ARID4B,ZBTB7A|
|RNA biosynthetic process|10.07|POLR2J3,TAF1,POLR2I,ERCC2,TAF7,CDK7,ARID4B,ZBTB7A|
|chromatin remodeling|7.62|TAF1,SIN3A,BRD2,TFPT,RAD54L2,ARID4B,ZBTB7A|
|nucleobase-containing compound biosynthetic process|6.64|POLR2J3,TAF1,POLR2I,ATP6V1A,ERCC2,TAF7,CDK7,ARID4B,ZBTB7A|
|protein-DNA complex organization|6.27|TAF1,SIN3A,BRD2,TFPT,RAD54L2,TAF7,ARID4B,ZBTB7A|
|heterocycle biosynthetic process|6.09|POLR2J3,TAF1,POLR2I,ATP6V1A,ERCC2,TAF7,CDK7,ARID4B,ZBTB7A|
|aromatic compound biosynthetic process|6.04|POLR2J3,TAF1,POLR2I,ATP6V1A,ERCC2,TAF7,CDK7,ARID4B,ZBTB7A|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.70|APAF1,CASP9|
|5S rDNA binding|368.47|RPTOR,MTOR|
|RNA polymerase III type 2 promoter sequence-specific DNA binding|368.47|RPTOR,MTOR|
|RNA polymerase III general transcription initiation factor binding|368.47|RPTOR,MTOR|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|331.62|APAF1,CYCS,CASP9|
|regulation of cysteine-type endopeptidase activity|14.70|APAF1,BAK1,CYCS,TRIAP1,CASP9|
|positive regulation of hydrolase activity|8.06|APAF1,BAK1,CYCS,PLAA,MTOR,HMGB2,CASP9|
|mitochondrial envelope|6.61|BAK1,CYCS,HCCS,MARCHF5,MTOR,PMPCB,TRIAP1,CRLS1,TIMM23B|
|mitochondrial membrane|6.26|BAK1,CYCS,HCCS,MARCHF5,MTOR,PMPCB,CRLS1,TIMM23B|
</modal>