Deferoxamine 11μM R07 exp350 [The Human Chemical-Genetic Interaction Map Project]

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====== Deferoxamine 11μM R07 exp350 ======
==== Mechanism of Action ====
Iron chelator, hypoxia mimetic, induces HIF-1‘± accumulation
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Metal Chelator
  * **<color #00a2e8>Class / Subclass 2:</color>** Metabolism / Metabolic Enzyme Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Deferoxamine mesylate%%
    * **<color #00a2e8>Synonyms:</color>** Desferrioxamine B mesylate; DFOM; Desferrioxamine B mesylate;DFOM
    * **<color #00a2e8>CAS #:</color>** 138-14-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/62881|62881]]
    * **<color #00a2e8>IUPAC:</color>** %%N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide;methanesulfonic acid%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
    * **<color #00a2e8>INCHI Key:</color>** IDDIJAWJANBQLJ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 656.8
    * **<color #00a2e8>Canonical SMILES:</color>** CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O.CS(=O)(=O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C26H52N6O11S
{{:chemogenomics:structures:chem-0207.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** D9533
    * **<color #00a2e8>Lot #:</color>** BCBV0071
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C25H48N6O8 561.36064; found 561.36098
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Desferrioxamine
    * **<color #00a2e8>Min:</color>** -7.4185; **<color #00a2e8>Max:</color>** 90.5910
{{:chemogenomics:dose_response:dr_425.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0084    |
| IC30  |0.0098    |
| IC40  |0.0112    |
| IC50  |0.0128    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 11µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.9
    * **<color #00a2e8>Numbers of reads</color>**: 18873851


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/31|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Deferoxamine_11uM_Round-7_exp350.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Deferoxamine 11μM R07 exp350'>
{{:chemogenomics:cranks_plots:exp350.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:N:NFS1|NFS1]]|-3.33|0.14|
|[[:human_genes:V:VPS25|VPS25]]|-2.97|0.14|
|[[:human_genes:I:INTS12|INTS12]]|-2.88|0.04|
|[[:human_genes:H:HSPA4|HSPA4]]|-2.65|0.08|
|[[:human_genes:A:ARMC5|ARMC5]]|-2.58|0.08|
|[[:human_genes:N:NUP160|NUP160]]|-2.57|0.16|
|[[:human_genes:P:PDS5B|PDS5B]]|-2.55|0.08|
|[[:human_genes:B:BRD1|BRD1]]|-2.53|0.08|
|[[:human_genes:I:INTS3|INTS3]]|-2.52|0.14|
|[[:human_genes:A:ARID3B|ARID3B]]|-2.48|0.15|
|[[:human_genes:R:RAB5C|RAB5C]]|-2.40|0.12|
|[[:human_genes:S:SREK1|SREK1]]|-2.40|0.14|
|[[:human_genes:S:SNRPG|SNRPG]]|-2.34|0.31|
|[[:human_genes:S:SKIV2L2|SKIV2L2]]|-2.34|0.41|
|[[:human_genes:T:TSPYL1|TSPYL1]]|-2.31|0.18|
|[[:human_genes:E:ETFDH|ETFDH]]|-2.30|0.15|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-2.30|0.14|
|[[:human_genes:R:RPS4Y1|RPS4Y1]]|-2.29|0.14|
|[[:human_genes:N:NELFB|NELFB]]|-2.29|0.15|
|[[:human_genes:Y:YY1|YY1]]|-2.24|0.23|
|[[:human_genes:S:SPIC|SPIC]]|-2.23|0.14|
|[[:human_genes:P:PCDHGB1|PCDHGB1]]|-2.23|0.14|
|[[:human_genes:S:SYNCRIP|SYNCRIP]]|-2.22|0.23|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.21|0.17|
|[[:human_genes:N:NELFE|NELFE]]|-2.19|0.17|
|[[:human_genes:E:ETAA1|ETAA1]]|-2.19|0.15|
|[[:human_genes:E:EMR1|EMR1]]|-2.18|0.15|
|[[:human_genes:M:MYCBPAP|MYCBPAP]]|-2.15|0.15|
|[[:human_genes:P:PARP1|PARP1]]|-2.14|0.19|
|[[:human_genes:D:DSCC1|DSCC1]]|-2.14|0.19|
|[[:human_genes:Z:ZNF592|ZNF592]]|2.35|0.08|
|[[:human_genes:P:PGLS|PGLS]]|2.35|0.04|
|[[:human_genes:C:CYCS|CYCS]]|2.36|0.04|
|[[:human_genes:K:KIR2DL4|KIR2DL4]]|2.36|0.05|
|[[:human_genes:T:TMEM161B|TMEM161B]]|2.36|0.04|
|[[:human_genes:H:HSPA9|HSPA9]]|2.42|0.33|
|[[:human_genes:O:ORAOV1|ORAOV1]]|2.42|0.07|
|[[:human_genes:M:MAT2B|MAT2B]]|2.44|0.03|
|[[:human_genes:M:MTPAP|MTPAP]]|2.45|0.03|
|[[:human_genes:M:MRPS21|MRPS21]]|2.45|0.06|
|[[:human_genes:G:GTF3A|GTF3A]]|2.45|0.04|
|[[:human_genes:B:BTAF1|BTAF1]]|2.45|0.04|
|[[:human_genes:T:TIMM23B|TIMM23B]]|2.51|0.08|
|[[:human_genes:M:MRPL53|MRPL53]]|2.53|0.04|
|[[:human_genes:A:ATIC|ATIC]]|2.58|0.02|
|[[:human_genes:D:DDX39A|DDX39A]]|2.67|0.01|
|[[:human_genes:E:ENY2|ENY2]]|2.76|0.02|
|[[:human_genes:P:PGP|PGP]]|2.79|<0.01|
|[[:human_genes:N:NSD1|NSD1]]|2.80|0.01|
|[[:human_genes:A:ALG5|ALG5]]|2.95|<0.01|
|[[:human_genes:T:TP53|TP53]]|2.96|<0.01|
|[[:human_genes:G:GPI|GPI]]|2.97|0.05|
|[[:human_genes:C:CHD2|CHD2]]|3.07|<0.01|
|[[:human_genes:A:ABCC1|ABCC1]]|3.07|<0.01|
|[[:human_genes:M:MRPL33|MRPL33]]|3.15|0.04|
|[[:human_genes:S:SLFN11|SLFN11]]|3.15|<0.01|
|[[:human_genes:D:DOHH|DOHH]]|3.25|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|3.32|<0.01|
|[[:human_genes:H:HK2|HK2]]|3.41|<0.01|
|[[:human_genes:A:AHCYL1|AHCYL1]]|3.48|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.111|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.088|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.077|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.077|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.068|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.067|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.064|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.063|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.061|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp532|TIC10 10μM R08 exp532]]|0.06|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.059|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.059|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.057|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.054|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp360|Genistein 15μM R07 exp360]]|0.053|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.052|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.051|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.082|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|0.082|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.078|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.068|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.066|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.064|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.063|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.058|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.051|<button type="primary" size="small" modal="26">View</button>|
</modal>


<modal id="1" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp350.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Deferoxamine 11μM R07 exp350  vs  GSK-J4 1.5μM R08 exp441">
{{:chemogenomics:comparison_plots:exp350_vs_exp441.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Deferoxamine 11μM R07 exp350  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp350_vs_exp84.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Deferoxamine 11μM R07 exp350  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp350.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp350.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp350_vs_exp478.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp350_vs_exp503.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp350_vs_exp517.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Deferoxamine 11μM R07 exp350  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp350.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Deferoxamine 11μM R07 exp350  vs  TIC10 10μM R08 exp532">
{{:chemogenomics:comparison_plots:exp350_vs_exp532.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp350_vs_exp529.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp350.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Deferoxamine 11μM R07 exp350  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp350_vs_exp515.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp350.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Genistein 15μM R07 exp360">
{{:chemogenomics:comparison_plots:exp350_vs_exp360.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Deferoxamine 11μM R07 exp350  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp350_vs_exp435.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp350_vs_exp527.png?nolink |}}
</modal>

<modal id="18" size="lg" title="CI-1040 9.5μM R08 exp472  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp350_vs_exp472.png?nolink |}}
</modal>

<modal id="19" size="lg" title="ABT-702 5μM plus Deferoxamine 11μM R07 exp321  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp321_vs_exp350.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp350_vs_exp440.png?nolink |}}
</modal>

<modal id="21" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp2_vs_exp350.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Benzoate 20000μM R08 exp456  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp350_vs_exp456.png?nolink |}}
</modal>

<modal id="23" size="lg" title="AICAR 240μM R05 exp211  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp211_vs_exp350.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp227_vs_exp350.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp3_vs_exp350.png?nolink |}}
</modal>

<modal id="26" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp350_vs_exp468.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|glucose 6-phosphate metabolic process|82.90|HK2,GPI,PGLS|
|organellar ribosome|25.12|MRPL33,MRPL53,MRPS21,MRPL23|
|mitochondrial protein-containing complex|12.06|MRPL33,MRPL53,TIMM23B,MRPS21,HSPA9,MRPL23|
|mitochondrial inner membrane|8.43|MRPL33,MRPL53,TIMM23B,MRPS21,HSPA9,CYCS,MRPL23|
|mitochondrial membrane|7.04|HK2,BAK1,MRPL33,MRPL53,TIMM23B,MRPS21,HSPA9,CYCS,MRPL23|
|mitochondrial envelope|6.61|HK2,BAK1,MRPL33,MRPL53,TIMM23B,MRPS21,HSPA9,CYCS,MRPL23|
</modal>