Dinaciclib 0.007μM R07 exp355 [The Human Chemical-Genetic Interaction Map Project]

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====== Dinaciclib 0.007μM R07 exp355 ======
==== Mechanism of Action ====
Inhibits CDK2, CDK5, CDK1, CDK9
  * **<color #00a2e8>Class / Subclass 1:</color>** Cell Cycle / Cell Cycle Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / Kinase Inhibitor
  * **<color #00a2e8>Class / Subclass 3:</color>** Gene Regulation / Transcription Inhibitor


==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Dinaciclib%%
    * **<color #00a2e8>Synonyms:</color>** SCH 727965
    * **<color #00a2e8>CAS #:</color>** 779353-01-4
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/46926350|46926350]]
    * **<color #00a2e8>IUPAC:</color>** %%2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** PIMQWRZWLQKKBJ-SFHVURJKSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 396.5
    * **<color #00a2e8>Canonical SMILES:</color>** CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO
    * **<color #00a2e8>Isomeric SMILES:</color>** CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO
    * **<color #00a2e8>Molecular Formula:</color>** C21H28N6O2
{{:chemogenomics:structures:chem-0210.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** D479725
    * **<color #00a2e8>Lot #:</color>** 2-MJS-149-1
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C21H28N6O2 397.23465; found 397.23573
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Dinaclib
    * **<color #00a2e8>Min:</color>** -9.1162; **<color #00a2e8>Max:</color>** 88.5880
{{:chemogenomics:dose_response:dr_383.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0052    |
| IC30  |0.0064    |
| IC40  |0.0077    |
| IC50  |0.0093    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 7nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.5
    * **<color #00a2e8>Numbers of reads</color>**: 18702654


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/24|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Dinaciclib_0.007uM_Round-7_exp355.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Dinaciclib 0.007μM R07 exp355'>
{{:chemogenomics:cranks_plots:exp355.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:Z:ZBTB1|ZBTB1]]|-2.51|0.22|
|[[:human_genes:P:PTPN23|PTPN23]]|-2.49|0.24|
|[[:human_genes:S:SMG5|SMG5]]|-2.49|0.53|
|[[:human_genes:P:PRMT7|PRMT7]]|-2.43|0.22|
|[[:human_genes:P:POLR1B|POLR1B]]|-2.43|0.54|
|[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.41|0.22|
|[[:human_genes:S:SMG7|SMG7]]|-2.41|0.36|
|[[:human_genes:C:CADPS|CADPS]]|-2.28|0.42|
|[[:human_genes:N:NDRG4|NDRG4]]|-2.27|0.30|
|[[:human_genes:N:NBAS|NBAS]]|-2.21|0.33|
|[[:human_genes:U:UBE4A|UBE4A]]|-2.19|0.33|
|[[:human_genes:R:RNF103-CHMP3|RNF103-CHMP3]]|-2.19|0.46|
|[[:human_genes:H:HEXIM1|HEXIM1]]|-2.17|0.33|
|[[:human_genes:N:NR1D2|NR1D2]]|-2.16|0.36|
|[[:human_genes:S:SYNCRIP|SYNCRIP]]|-2.14|0.42|
|[[:human_genes:M:MKLN1|MKLN1]]|-2.13|0.35|
|[[:human_genes:Y:YPEL5|YPEL5]]|-2.12|0.35|
|[[:human_genes:F:FOXK1|FOXK1]]|-2.11|0.36|
|[[:human_genes:K:KPNA2|KPNA2]]|-2.10|0.35|
|[[:human_genes:K:KCTD10|KCTD10]]|-2.09|0.35|
|[[:human_genes:N:NCAPH|NCAPH]]|-2.07|0.53|
|[[:human_genes:C:C12orf66|C12orf66]]|-2.06|0.36|
|[[:human_genes:M:MUL1|MUL1]]|-2.05|0.42|
|[[:human_genes:A:ACP1|ACP1]]|-2.04|0.36|
|[[:human_genes:I:IPO13|IPO13]]|-2.04|0.46|
|[[:human_genes:P:PTPDC1|PTPDC1]]|-2.04|0.42|
|[[:human_genes:M:MTFR1|MTFR1]]|-2.03|0.36|
|[[:human_genes:T:TOMM70A|TOMM70A]]|-2.02|0.36|
|[[:human_genes:K:KIF11|KIF11]]|-2.01|0.77|
|[[:human_genes:A:ADK|ADK]]|-2.00|0.36|
|[[:human_genes:F:FAU|FAU]]|2.22|0.24|
|[[:human_genes:S:SRM|SRM]]|2.22|0.07|
|[[:human_genes:P:PLAA|PLAA]]|2.22|0.07|
|[[:human_genes:X:XPR1|XPR1]]|2.27|0.06|
|[[:human_genes:H:HDAC7|HDAC7]]|2.31|0.05|
|[[:human_genes:C:CDK5|CDK5]]|2.33|0.04|
|[[:human_genes:M:MARCH5|MARCH5]]|2.36|0.04|
|[[:human_genes:N:NRBP1|NRBP1]]|2.40|0.06|
|[[:human_genes:E:EBF1|EBF1]]|2.53|0.04|
|[[:human_genes:L:LSG1|LSG1]]|2.56|0.04|
|[[:human_genes:A:ARID4B|ARID4B]]|2.59|0.03|
|[[:human_genes:P:PHF2|PHF2]]|2.65|0.04|
|[[:human_genes:A:ATIC|ATIC]]|2.68|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|2.71|0.02|
|[[:human_genes:U:UBQLN1|UBQLN1]]|2.72|<0.01|
|[[:human_genes:K:KLF16|KLF16]]|2.81|0.03|
|[[:human_genes:S:SSU72|SSU72]]|2.84|<0.01|
|[[:human_genes:K:KIAA0195|KIAA0195]]|2.89|<0.01|
|[[:human_genes:M:MDH1|MDH1]]|2.91|<0.01|
|[[:human_genes:V:VDAC2|VDAC2]]|2.93|<0.01|
|[[:human_genes:E:EIF3G|EIF3G]]|3.19|<0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.20|<0.01|
|[[:human_genes:I:INTS8|INTS8]]|3.25|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|3.36|<0.01|
|[[:human_genes:U:UMPS|UMPS]]|3.37|0.06|
|[[:human_genes:I:INTS1|INTS1]]|3.37|<0.01|
|[[:human_genes:I:INTS6|INTS6]]|3.87|0.01|
|[[:human_genes:C:C2CD5|C2CD5]]|4.46|<0.01|
|[[:human_genes:F:FIBP|FIBP]]|5.11|<0.01|
|[[:human_genes:I:IMPDH2|IMPDH2]]|5.25|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.085|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.077|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.076|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.074|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.072|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.067|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.064|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.061|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.06|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.06|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.059|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.056|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.055|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.053|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.052|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.103|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.063|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.062|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.062|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.062|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.061|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.057|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.056|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.051|<button type="primary" size="small" modal="24">View</button>|
</modal>


<modal id="1" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp355_vs_exp80.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp355.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp355_vs_exp512.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp355_vs_exp524.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp355_vs_exp503.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp355_vs_exp485.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp355.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp355_vs_exp489.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp355_vs_exp478.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp355_vs_exp488.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp234_vs_exp355.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp355_vs_exp357.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp355.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp355_vs_exp85.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp355_vs_exp435.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Benzoate 20000μM R08 exp456  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp355_vs_exp456.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Bleomycin 5μM R08 exp459  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp355_vs_exp459.png?nolink |}}
</modal>

<modal id="18" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp259_vs_exp355.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp355_vs_exp440.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp3_vs_exp355.png?nolink |}}
</modal>

<modal id="21" size="lg" title="AICAR 240μM R03 exp116  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp116_vs_exp355.png?nolink |}}
</modal>

<modal id="22" size="lg" title="AICAR 240μM R05 exp211  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp211_vs_exp355.png?nolink |}}
</modal>

<modal id="23" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp2_vs_exp355.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Centrinone 0.5μM R07 exp343  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp343_vs_exp355.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|integrator complex|103.62|INTS6,INTS1,INTS8|
|snRNA 3-end processing|78.95|INTS6,INTS1,INTS8|
|RNA 3-end processing|31.40|INTS6,INTS1,INTS8,SSU72,AHCYL1|
</modal>