Docosahexaenoic-acid 50μM R07 exp356 [The Human Chemical-Genetic Interaction Map Project]

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====== Docosahexaenoic-acid 50μM R07 exp356 ======
==== Mechanism of Action ====
Essential omega-3 fatty acid
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolite




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Docosahexaenoic acid%%
    * **<color #00a2e8>Synonyms:</color>** DHA; Cervonic Acid; DHA;Cervonic Acid
    * **<color #00a2e8>CAS #:</color>** 6217-54-5
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/445580|445580]]
    * **<color #00a2e8>IUPAC:</color>** %%(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
    * **<color #00a2e8>INCHI Key:</color>** MBMBGCFOFBJSGT-KUBAVDMBSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 328.5
    * **<color #00a2e8>Canonical SMILES:</color>** CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCC(=O)O
    * **<color #00a2e8>Molecular Formula:</color>** C22H32O2
{{:chemogenomics:structures:chem-0211.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** D494500
    * **<color #00a2e8>Lot #:</color>** 1-JLW-41-1
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M-H)- Calcd for C22 H32 O2 327.23295; found 327.23317
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** DHA
    * **<color #00a2e8>Min:</color>** -2.8808; **<color #00a2e8>Max:</color>** 99.6218
{{:chemogenomics:dose_response:dr_426.png?nolink&500 |}}
\\ 
\\ 
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |38.0548    |
| IC30  |44.3385    |
| IC40  |50.4627    |
| IC50  |56.9511    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 50µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 3.6
    * **<color #00a2e8>Numbers of reads</color>**: 20259389


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|20/1|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Docosahexaenoic_acid_50uM_Round-7_exp356.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Docosahexaenoic-acid 50μM R07 exp356'>
{{:chemogenomics:cranks_plots:exp356.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:L:LRP8|LRP8]]|-4.32|<0.01|
|[[:human_genes:G:GCLM|GCLM]]|-4.01|<0.01|
|[[:human_genes:E:EEFSEC|EEFSEC]]|-3.74|<0.01|
|[[:human_genes:N:NPRL2|NPRL2]]|-3.63|<0.01|
|[[:human_genes:N:NPRL3|NPRL3]]|-3.39|<0.01|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-3.28|<0.01|
|[[:human_genes:G:GCLC|GCLC]]|-3.19|<0.01|
|[[:human_genes:Q:QRICH1|QRICH1]]|-3.05|<0.01|
|[[:human_genes:F:FBXL5|FBXL5]]|-3.05|<0.01|
|[[:human_genes:F:FAM122A|FAM122A]]|-3.00|<0.01|
|[[:human_genes:S:SEPHS2|SEPHS2]]|-3.00|<0.01|
|[[:human_genes:C:CNOT8|CNOT8]]|-2.93|<0.01|
|[[:human_genes:A:ABCC1|ABCC1]]|-2.90|<0.01|
|[[:human_genes:B:BCL2L1|BCL2L1]]|-2.90|<0.01|
|[[:human_genes:Z:ZSCAN12|ZSCAN12]]|-2.85|0.08|
|[[:human_genes:D:DDI2|DDI2]]|-2.84|<0.01|
|[[:human_genes:C:CNOT2|CNOT2]]|-2.72|<0.01|
|[[:human_genes:S:SZT2|SZT2]]|-2.60|0.01|
|[[:human_genes:R:RPS25|RPS25]]|-2.58|0.01|
|[[:human_genes:S:SLC22A4|SLC22A4]]|-2.48|0.02|
|[[:human_genes:D:DHX36|DHX36]]|-2.35|0.08|
|[[:human_genes:C:CGN|CGN]]|-2.34|0.12|
|[[:human_genes:N:NGLY1|NGLY1]]|-2.34|0.05|
|[[:human_genes:C:CHPF2|CHPF2]]|-2.32|0.13|
|[[:human_genes:M:MSI2|MSI2]]|-2.32|0.08|
|[[:human_genes:N:NOTCH2NL|NOTCH2NL]]|-2.31|0.08|
|[[:human_genes:H:HSP90B1|HSP90B1]]|-2.28|0.08|
|[[:human_genes:P:PPP2CA|PPP2CA]]|-2.28|0.08|
|[[:human_genes:C:CMAS|CMAS]]|-2.26|0.07|
|[[:human_genes:R:RAB7A|RAB7A]]|-2.26|0.07|
|[[:human_genes:P:PPOX|PPOX]]|2.01|0.29|
|[[:human_genes:T:TPX2|TPX2]]|2.01|0.39|
|[[:human_genes:K:KRTAP20-1|KRTAP20-1]]|2.03|0.28|
|[[:human_genes:M:MSLN|MSLN]]|2.03|0.28|
|[[:human_genes:E:EMX1|EMX1]]|2.04|0.28|
|[[:human_genes:Y:YTHDC1|YTHDC1]]|2.04|0.58|
|[[:human_genes:K:KLF16|KLF16]]|2.05|0.51|
|[[:human_genes:P:POLA2|POLA2]]|2.06|0.55|
|[[:human_genes:C:CACNB2|CACNB2]]|2.07|0.26|
|[[:human_genes:P:POR|POR]]|2.07|0.26|
|[[:human_genes:Z:ZNF563|ZNF563]]|2.07|0.26|
|[[:human_genes:E:EIF5B|EIF5B]]|2.10|0.61|
|[[:human_genes:C:CERK|CERK]]|2.12|0.24|
|[[:human_genes:G:GPR55|GPR55]]|2.13|0.24|
|[[:human_genes:P:POLA1|POLA1]]|2.14|0.65|
|[[:human_genes:G:GAS1|GAS1]]|2.19|0.22|
|[[:human_genes:U:USHBP1|USHBP1]]|2.23|0.26|
|[[:human_genes:G:GPNMB|GPNMB]]|2.26|0.24|
|[[:human_genes:B:BAK1|BAK1]]|2.28|0.16|
|[[:human_genes:A:ARRDC3|ARRDC3]]|2.29|0.24|
|[[:human_genes:M:MARCH5|MARCH5]]|2.29|0.16|
|[[:human_genes:M:MCL1|MCL1]]|2.43|0.16|
|[[:human_genes:A:ACSL4|ACSL4]]|2.43|0.10|
|[[:human_genes:L:LDB3|LDB3]]|2.46|0.09|
|[[:human_genes:P:PFKP|PFKP]]|2.48|0.09|
|[[:human_genes:P:PML|PML]]|2.49|0.09|
|[[:human_genes:Z:ZNF592|ZNF592]]|2.50|0.22|
|[[:human_genes:P:PTMA|PTMA]]|2.82|0.08|
|[[:human_genes:S:SNRPF|SNRPF]]|3.00|0.51|
|[[:human_genes:S:SRM|SRM]]|3.04|0.02|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|0.088|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|0.079|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.077|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|0.076|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp292|Menadione 5μM R06 exp292]]|0.074|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.069|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|0.067|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.067|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|0.058|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.056|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|0.072|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|0.062|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|0.059|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.057|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.057|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|0.055|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|0.055|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.052|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|0.051|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.051|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.051|<button type="primary" size="small" modal="21">View</button>|
</modal>


<modal id="1" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Epigallocatechin gallate 20μM R05 exp230">
{{:chemogenomics:comparison_plots:exp230_vs_exp356.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp356_vs_exp436.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp356_vs_exp416.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Dynasore 10μM R04 exp180">
{{:chemogenomics:comparison_plots:exp180_vs_exp356.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Menadione 5μM R06 exp292">
{{:chemogenomics:comparison_plots:exp292_vs_exp356.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp356_vs_exp517.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  UMK57 0.6μM R03 exp107">
{{:chemogenomics:comparison_plots:exp107_vs_exp356.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp356_vs_exp529.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  S-trityl-L-cysteine 0.5μM R05 exp243">
{{:chemogenomics:comparison_plots:exp243_vs_exp356.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Docosahexaenoic-acid 50μM R07 exp356  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp356_vs_exp84.png?nolink |}}
</modal>

<modal id="11" size="lg" title="3-Bromopyruvate 7μM R04 exp175  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp175_vs_exp356.png?nolink |}}
</modal>

<modal id="12" size="lg" title="2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp311_vs_exp356.png?nolink |}}
</modal>

<modal id="13" size="lg" title="2-Methoxyestradiol 0.55μM R07 exp310  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp310_vs_exp356.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp227_vs_exp356.png?nolink |}}
</modal>

<modal id="15" size="lg" title="BVD-523 15μM R02 exp67  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp356_vs_exp67.png?nolink |}}
</modal>

<modal id="16" size="lg" title="2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp312_vs_exp356.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Combretastatin A4 0.002 to 0.003μM day4 R04 exp179  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp179_vs_exp356.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Diepoxybutane 3μM R07 exp354  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp354_vs_exp356.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Bortezomib 0.005μM R00 exp6  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp356_vs_exp6.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Artemisinin 50μM R08 exp450  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp356_vs_exp450.png?nolink |}}
</modal>

<modal id="21" size="lg" title="BML-284 0.09μM R08 exp460  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp356_vs_exp460.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|GATOR1 complex|614.04|NPRL2,NPRL3|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>