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Ask your administrator if you think this is wrong. ====== Dorsomorphin 5μM R07 exp357 ====== ==== Mechanism of Action ==== Putative inhibitor of AMPK and BMP signalling * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Kinase Inhibitor ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%Dorsomorphin%% * **<color #00a2e8>Synonyms:</color>** BML-275; Compound C * **<color #00a2e8>CAS #:</color>** 866405-64-3 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/11524144|11524144]] * **<color #00a2e8>IUPAC:</color>** %%6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 * **<color #00a2e8>INCHI Key:</color>** XHBVYDAKJHETMP-UHFFFAOYSA-N * **<color #00a2e8>Molecular Weight:</color>** 399.5 * **<color #00a2e8>Canonical SMILES:</color>** C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3 * **<color #00a2e8>Isomeric SMILES:</color>** N/A * **<color #00a2e8>Molecular Formula:</color>** C24H25N5O {{:chemogenomics:structures:chem-0212.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** Ark Pharm Inc. * **<color #00a2e8>Catalog #:</color>** AK-88052 * **<color #00a2e8>Lot #:</color>** YF0257195-170620001 </panel> <panel title='Compound Characterization' collapsed='true'> * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C24H25N5O 400.21319; found 400.21387 </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** Dorsomorphin * **<color #00a2e8>Min:</color>** 1.3456; **<color #00a2e8>Max:</color>** 94.1274 {{:chemogenomics:dose_response:dr_427.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |N/A | | IC20 |1.5365 | | IC30 |2.2301 | | IC40 |3.0231 | | IC50 |4.0073 | | IC60 |N/A | | IC70 |N/A | | IC80 |N/A | | IC90 |N/A | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 07 * **<color #00a2e8>Dose</color>**: 5µM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: 1.0 * **<color #00a2e8>Numbers of reads</color>**: 16049330 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |21/17|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Dorsomorphin_5uM_Round-7_exp357.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='Dorsomorphin 5μM R07 exp357'> {{:chemogenomics:cranks_plots:exp357.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:P:PRAMEF25|PRAMEF25]]|-4.24|0.03| |[[:human_genes:P:PRAMEF26|PRAMEF26]]|-4.20|0.03| |[[:human_genes:B:BCL2|BCL2]]|-3.99|<0.01| |[[:human_genes:R:RANBP1|RANBP1]]|-3.54|<0.01| |[[:human_genes:C:CLK3|CLK3]]|-3.28|<0.01| |[[:human_genes:P:PDS5B|PDS5B]]|-3.15|<0.01| |[[:human_genes:K:KIF20A|KIF20A]]|-3.05|<0.01| |[[:human_genes:Z:ZNF451|ZNF451]]|-2.96|<0.01| |[[:human_genes:A:ARL1|ARL1]]|-2.93|<0.01| |[[:human_genes:N:NRAS|NRAS]]|-2.86|0.01| |[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.77|0.02| |[[:human_genes:L:LIG4|LIG4]]|-2.73|0.02| |[[:human_genes:S:SCAF1|SCAF1]]|-2.72|0.22| |[[:human_genes:D:DCLRE1C|DCLRE1C]]|-2.67|0.01| |[[:human_genes:T:TCF4|TCF4]]|-2.65|0.01| |[[:human_genes:P:PUS7|PUS7]]|-2.58|0.03| |[[:human_genes:M:MAD2L2|MAD2L2]]|-2.57|0.02| |[[:human_genes:P:PSME3|PSME3]]|-2.56|0.02| |[[:human_genes:R:RRM2B|RRM2B]]|-2.46|0.03| |[[:human_genes:C:C1orf68|C1orf68]]|-2.42|0.03| |[[:human_genes:E:EDF1|EDF1]]|-2.42|0.03| |[[:human_genes:S:SMG1|SMG1]]|-2.39|0.04| |[[:human_genes:O:OTUB1|OTUB1]]|-2.36|0.07| |[[:human_genes:H:HIST1H1B|HIST1H1B]]|-2.32|0.05| |[[:human_genes:N:NELFA|NELFA]]|-2.32|0.07| |[[:human_genes:K:KCNJ2|KCNJ2]]|-2.29|0.06| |[[:human_genes:I:INCENP|INCENP]]|-2.29|0.21| |[[:human_genes:I:IGLL1|IGLL1]]|-2.28|0.06| |[[:human_genes:M:MAD2L1|MAD2L1]]|-2.28|0.06| |[[:human_genes:Y:YPEL5|YPEL5]]|-2.25|0.06| |[[:human_genes:B:BRWD1|BRWD1]]|2.20|0.09| |[[:human_genes:K:KCTD5|KCTD5]]|2.21|0.09| |[[:human_genes:S:SLC7A1|SLC7A1]]|2.22|0.12| |[[:human_genes:C:C15orf41|C15orf41]]|2.25|0.07| |[[:human_genes:C:CYCS|CYCS]]|2.28|0.06| |[[:human_genes:M:MRPL23|MRPL23]]|2.29|0.06| |[[:human_genes:S:SART1|SART1]]|2.31|0.35| |[[:human_genes:L:LARP1|LARP1]]|2.33|0.09| |[[:human_genes:T:TFAP4|TFAP4]]|2.34|0.05| |[[:human_genes:L:LOC100505679|LOC100505679]]|2.35|0.44| |[[:human_genes:D:DGKD|DGKD]]|2.41|0.04| |[[:human_genes:E:EIF4A1|EIF4A1]]|2.42|0.06| |[[:human_genes:O:OAZ1|OAZ1]]|2.43|0.04| |[[:human_genes:S:SMEK1|SMEK1]]|2.44|0.04| |[[:human_genes:P:PPA1|PPA1]]|2.57|0.07| |[[:human_genes:K:KLF16|KLF16]]|2.64|0.06| |[[:human_genes:E:EBF1|EBF1]]|2.70|0.02| |[[:human_genes:S:SERF2|SERF2]]|2.71|<0.01| |[[:human_genes:S:SETDB1|SETDB1]]|2.74|0.04| |[[:human_genes:C:CRLS1|CRLS1]]|2.90|<0.01| |[[:human_genes:U:UBQLN1|UBQLN1]]|3.17|0.00| |[[:human_genes:L:LCMT1|LCMT1]]|3.32|0.00| |[[:human_genes:M:MARCH5|MARCH5]]|3.39|0.00| |[[:human_genes:A:APAF1|APAF1]]|3.47|0.00| |[[:human_genes:V:VDAC2|VDAC2]]|3.48|0.00| |[[:human_genes:P:PLAA|PLAA]]|3.75|0.00| |[[:human_genes:T:TAZ|TAZ]]|4.36|0.00| |[[:human_genes:M:MLST8|MLST8]]|4.92|0.00| |[[:human_genes:B:BAK1|BAK1]]|5.23|0.00| |[[:human_genes:T:TOP2B|TOP2B]]|7.21|0.00| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.09|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp485|GSK626616 14μM R08 exp485]]|0.089|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp502|Milciclib 2μM R08 exp502]]|0.088|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.084|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.084|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.083|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp240|Pyridostatin 4μM R05 exp240]]|0.083|<button type="primary" size="small" modal="7">View</button>| |[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.079|<button type="primary" size="small" modal="8">View</button>| |[[:results:exp85|UM0129480 7μM R02 exp85]]|0.079|<button type="primary" size="small" modal="9">View</button>| |[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.077|<button type="primary" size="small" modal="10">View</button>| |[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.075|<button type="primary" size="small" modal="11">View</button>| |[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.072|<button type="primary" size="small" modal="12">View</button>| |[[:results:exp517|Quercetin 20μM R08 exp517]]|0.071|<button type="primary" size="small" modal="13">View</button>| |[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.071|<button type="primary" size="small" modal="14">View</button>| |[[:results:exp512|Olaparib 4μM R08 exp512]]|0.069|<button type="primary" size="small" modal="15">View</button>| |[[:results:exp135|MS023 7μM R03 exp135]]|0.069|<button type="primary" size="small" modal="16">View</button>| |[[:results:exp492|iCRT14 30μM R08 exp492]]|0.06|<button type="primary" size="small" modal="17">View</button>| |[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.06|<button type="primary" size="small" modal="18">View</button>| |[[:results:exp443|SNS-032 15μM R08 exp443]]|0.058|<button type="primary" size="small" modal="19">View</button>| |[[:results:exp515|PU-H71 1μM R08 exp515]]|0.056|<button type="primary" size="small" modal="20">View</button>| |[[:results:exp38|Wortmannin 5μM R00 exp38]]|0.056|<button type="primary" size="small" modal="21">View</button>| |[[:results:exp360|Genistein 15μM R07 exp360]]|0.056|<button type="primary" size="small" modal="22">View</button>| |[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.055|<button type="primary" size="small" modal="23">View</button>| |[[:results:exp34|Rotenone 20μM R00 exp34]]|0.055|<button type="primary" size="small" modal="24">View</button>| |[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.053|<button type="primary" size="small" modal="25">View</button>| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.052|<button type="primary" size="small" modal="26">View</button>| |[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.051|<button type="primary" size="small" modal="27">View</button>| |[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.085|<button type="primary" size="small" modal="28">View</button>| |[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.085|<button type="primary" size="small" modal="29">View</button>| |[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.078|<button type="primary" size="small" modal="30">View</button>| |[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.076|<button type="primary" size="small" modal="31">View</button>| |[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.075|<button type="primary" size="small" modal="32">View</button>| |[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.07|<button type="primary" size="small" modal="33">View</button>| |[[:results:exp67|BVD-523 15μM R02 exp67]]|0.07|<button type="primary" size="small" modal="34">View</button>| |[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.065|<button type="primary" size="small" modal="35">View</button>| |[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.062|<button type="primary" size="small" modal="36">View</button>| |[[:results:exp116|AICAR 240μM R03 exp116]]|0.059|<button type="primary" size="small" modal="37">View</button>| |[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.056|<button type="primary" size="small" modal="38">View</button>| |[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.055|<button type="primary" size="small" modal="39">View</button>| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.054|<button type="primary" size="small" modal="40">View</button>| |[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.053|<button type="primary" size="small" modal="41">View</button>| |[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|0.053|<button type="primary" size="small" modal="42">View</button>| |[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.052|<button type="primary" size="small" modal="43">View</button>| |[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|0.051|<button type="primary" size="small" modal="44">View</button>| </modal> <modal id="1" size="lg" title="Dorsomorphin 5μM R07 exp357 vs RO-3307 4.7μM R02 exp80"> {{:chemogenomics:comparison_plots:exp357_vs_exp80.png?nolink |}} </modal> <modal id="2" size="lg" title="Dorsomorphin 5μM R07 exp357 vs GSK626616 14μM R08 exp485"> {{:chemogenomics:comparison_plots:exp357_vs_exp485.png?nolink |}} </modal> <modal id="3" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Milciclib 2μM R08 exp502"> {{:chemogenomics:comparison_plots:exp357_vs_exp502.png?nolink |}} </modal> <modal id="4" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp357_vs_exp478.png?nolink |}} </modal> <modal id="5" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp357_vs_exp488.png?nolink |}} </modal> <modal id="6" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Mitomycin-C 0.06μM R08 exp503"> {{:chemogenomics:comparison_plots:exp357_vs_exp503.png?nolink |}} </modal> <modal id="7" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Pyridostatin 4μM R05 exp240"> {{:chemogenomics:comparison_plots:exp240_vs_exp357.png?nolink |}} </modal> <modal id="8" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Staurosporine 0.02μM R08 exp524"> {{:chemogenomics:comparison_plots:exp357_vs_exp524.png?nolink |}} </modal> <modal id="9" size="lg" title="Dorsomorphin 5μM R07 exp357 vs UM0129480 7μM R02 exp85"> {{:chemogenomics:comparison_plots:exp357_vs_exp85.png?nolink |}} </modal> <modal id="10" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Hippuristanol 0.12μM R08 exp489 no dilution day6"> {{:chemogenomics:comparison_plots:exp357_vs_exp489.png?nolink |}} </modal> <modal id="11" size="lg" title="Dorsomorphin 5μM R07 exp357 vs JQ1 0.8μM R08 exp435"> {{:chemogenomics:comparison_plots:exp357_vs_exp435.png?nolink |}} </modal> <modal id="12" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Etoposide 0.3μM R05 exp199"> {{:chemogenomics:comparison_plots:exp199_vs_exp357.png?nolink |}} </modal> <modal id="13" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Quercetin 20μM R08 exp517"> {{:chemogenomics:comparison_plots:exp357_vs_exp517.png?nolink |}} </modal> <modal id="14" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Pimelic-diphenylamide-106 5μM R00 exp28"> {{:chemogenomics:comparison_plots:exp28_vs_exp357.png?nolink |}} </modal> <modal id="15" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Olaparib 4μM R08 exp512"> {{:chemogenomics:comparison_plots:exp357_vs_exp512.png?nolink |}} </modal> <modal id="16" size="lg" title="Dorsomorphin 5μM R07 exp357 vs MS023 7μM R03 exp135"> {{:chemogenomics:comparison_plots:exp135_vs_exp357.png?nolink |}} </modal> <modal id="17" size="lg" title="Dorsomorphin 5μM R07 exp357 vs iCRT14 30μM R08 exp492"> {{:chemogenomics:comparison_plots:exp357_vs_exp492.png?nolink |}} </modal> <modal id="18" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Hydroxyurea 100μM R07 exp329"> {{:chemogenomics:comparison_plots:exp329_vs_exp357.png?nolink |}} </modal> <modal id="19" size="lg" title="Dorsomorphin 5μM R07 exp357 vs SNS-032 15μM R08 exp443"> {{:chemogenomics:comparison_plots:exp357_vs_exp443.png?nolink |}} </modal> <modal id="20" size="lg" title="Dorsomorphin 5μM R07 exp357 vs PU-H71 1μM R08 exp515"> {{:chemogenomics:comparison_plots:exp357_vs_exp515.png?nolink |}} </modal> <modal id="21" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Wortmannin 5μM R00 exp38"> {{:chemogenomics:comparison_plots:exp357_vs_exp38.png?nolink |}} </modal> <modal id="22" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Genistein 15μM R07 exp360"> {{:chemogenomics:comparison_plots:exp357_vs_exp360.png?nolink |}} </modal> <modal id="23" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Thapsigargin 0.005μM R07 exp407"> {{:chemogenomics:comparison_plots:exp357_vs_exp407.png?nolink |}} </modal> <modal id="24" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Rotenone 20μM R00 exp34"> {{:chemogenomics:comparison_plots:exp34_vs_exp357.png?nolink |}} </modal> <modal id="25" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Tanespimycin 14μM R08 exp527"> {{:chemogenomics:comparison_plots:exp357_vs_exp527.png?nolink |}} </modal> <modal id="26" size="lg" title="Dorsomorphin 5μM R07 exp357 vs THZ1 0.06μM R08 exp531"> {{:chemogenomics:comparison_plots:exp357_vs_exp531.png?nolink |}} </modal> <modal id="27" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Thimerosal 0.85μM R08 exp529"> {{:chemogenomics:comparison_plots:exp357_vs_exp529.png?nolink |}} </modal> <modal id="28" size="lg" title="Aphidicolin 0.4μM R08 exp440 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp440.png?nolink |}} </modal> <modal id="29" size="lg" title="Benzoate 20000μM R08 exp456 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp456.png?nolink |}} </modal> <modal id="30" size="lg" title="Actinomycin-D 0.001μM R00 exp3 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp3_vs_exp357.png?nolink |}} </modal> <modal id="31" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp259_vs_exp357.png?nolink |}} </modal> <modal id="32" size="lg" title="CR131-b 0.005μM R08 exp474 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp474.png?nolink |}} </modal> <modal id="33" size="lg" title="Bleomycin 5μM R08 exp459 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp459.png?nolink |}} </modal> <modal id="34" size="lg" title="BVD-523 15μM R02 exp67 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp67.png?nolink |}} </modal> <modal id="35" size="lg" title="Centrinone 0.5μM R07 exp343 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp343_vs_exp357.png?nolink |}} </modal> <modal id="36" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp445.png?nolink |}} </modal> <modal id="37" size="lg" title="AICAR 240μM R03 exp116 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp116_vs_exp357.png?nolink |}} </modal> <modal id="38" size="lg" title="Dinaciclib 0.007μM R07 exp355 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp355_vs_exp357.png?nolink |}} </modal> <modal id="39" size="lg" title="BML-284 0.09μM R08 exp460 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp460.png?nolink |}} </modal> <modal id="40" size="lg" title="5-Fluorouracil 20μM R00 exp2 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp2_vs_exp357.png?nolink |}} </modal> <modal id="41" size="lg" title="CB-5083 0.4μM R08 exp468 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp468.png?nolink |}} </modal> <modal id="42" size="lg" title="5-Azacytidine 2μM R07 exp330 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp330_vs_exp357.png?nolink |}} </modal> <modal id="43" size="lg" title="Cannabidiol 20μM R08 exp466 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp466.png?nolink |}} </modal> <modal id="44" size="lg" title="Bortezomib 0.05μM R00 exp7 vs Dorsomorphin 5μM R07 exp357"> {{:chemogenomics:comparison_plots:exp357_vs_exp7.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms"> ^GO Term^Fold Change^Genes^ |regulation of mitotic cell cycle phase transition|11.48|BCL2,MAD2L2,PSME3,RRM2B,INCENP,MAD2L1| |DNA damage response|6.88|BCL2,PDS5B,LIG4,DCLRE1C,MAD2L2,RRM2B,SMG1,OTUB1| </modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms"> ^GO Term^Fold Change^Genes^ |mitochondrial membrane|7.04|BAK1,VDAC2,MARCHF5,CRLS1,MRPL23,CYCS,ROMO1,MTG2,PMAIP1| |mitochondrial envelope|6.61|BAK1,VDAC2,MARCHF5,CRLS1,MRPL23,CYCS,ROMO1,MTG2,PMAIP1| </modal> Last modified: 2026/01/15 21:36by 127.0.0.1