Rifampicin 30μM R08 exp430 [The Human Chemical-Genetic Interaction Map Project]

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====== Rifampicin 30μM R08 exp430 ======
==== Mechanism of Action ====
Inhibits bacterial RNA polymerase, induces hepatic cytochrome P450 enzymes
  * **<color #00a2e8>Class / Subclass 1:</color>** Infectious Disease / Antibiotic




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Rifampicin%%
    * **<color #00a2e8>Synonyms:</color>** Rifampin; Rifamycin AMP
    * **<color #00a2e8>CAS #:</color>** 13292-46-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/135398735|135398735]]
    * **<color #00a2e8>IUPAC:</color>** %%[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** JQXXHWHPUNPDRT-WLSIYKJHSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 822.9
    * **<color #00a2e8>Canonical SMILES:</color>** CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)/C
    * **<color #00a2e8>Molecular Formula:</color>** C43H58N4O12
{{:chemogenomics:structures:chem-0017.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-B0272
    * **<color #00a2e8>Lot #:</color>** 33587
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C43H58N4O12 823.4124; found 823.4128
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Rifampicin
    * **<color #00a2e8>Min:</color>** -6.7213; **<color #00a2e8>Max:</color>** 44.6632
{{:chemogenomics:dose_response:dr_574.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |6.1970    |
| IC20  |17.2600    |
| IC30  |34.1100    |
| IC40  |59.6000    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 30µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.5
    * **<color #00a2e8>Numbers of reads</color>**: 17692944


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Rifampicin_30uM_Round-8_exp430.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Rifampicin 30μM R08 exp430'>
{{:chemogenomics:cranks_plots:exp430.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:D:DARS2|DARS2]]|-2.90|0.24|
|[[:human_genes:F:FBXW7|FBXW7]]|-2.57|0.24|
|[[:human_genes:P:PDSS1|PDSS1]]|-2.42|0.24|
|[[:human_genes:N:NME6|NME6]]|-2.42|0.24|
|[[:human_genes:C:CXorf56|CXorf56]]|-2.38|0.24|
|[[:human_genes:L:LIPN|LIPN]]|-2.37|0.24|
|[[:human_genes:S:SNF8|SNF8]]|-2.34|0.24|
|[[:human_genes:S:SLC25A37|SLC25A37]]|-2.29|0.25|
|[[:human_genes:S:SPR|SPR]]|-2.27|0.24|
|[[:human_genes:C:CALML4|CALML4]]|-2.26|0.38|
|[[:human_genes:E:ETFDH|ETFDH]]|-2.24|0.24|
|[[:human_genes:R:RPS8|RPS8]]|-2.23|0.74|
|[[:human_genes:G:GPR75-ASB3|GPR75-ASB3]]|-2.22|0.32|
|[[:human_genes:T:TSSC1|TSSC1]]|-2.19|0.24|
|[[:human_genes:F:FBXO46|FBXO46]]|-2.18|0.34|
|[[:human_genes:S:SRPK1|SRPK1]]|-2.15|0.25|
|[[:human_genes:C:CHMP2A|CHMP2A]]|-2.10|0.53|
|[[:human_genes:I:ILF3|ILF3]]|-2.07|0.58|
|[[:human_genes:R:RTF1|RTF1]]|-2.06|0.39|
|[[:human_genes:N:NPRL2|NPRL2]]|-2.06|0.39|
|[[:human_genes:P:PRAMEF10|PRAMEF10]]|-2.04|0.34|
|[[:human_genes:G:GABRB1|GABRB1]]|-2.03|0.34|
|[[:human_genes:F:FRY|FRY]]|-2.03|0.34|
|[[:human_genes:P:PLAT|PLAT]]|-2.03|0.53|
|[[:human_genes:R:RBPJ|RBPJ]]|-2.02|0.46|
|[[:human_genes:K:KIAA0368|KIAA0368]]|-2.00|0.38|
|[[:human_genes:S:SNRPD3|SNRPD3]]|-2.00|0.81|
|[[:human_genes:D:DNAJC3|DNAJC3]]|-1.97|0.39|
|[[:human_genes:T:TPRKB|TPRKB]]|-1.97|0.51|
|[[:human_genes:Z:ZBTB49|ZBTB49]]|-1.96|0.39|
|[[:human_genes:A:AATF|AATF]]|1.86|0.79|
|[[:human_genes:R:RNF6|RNF6]]|1.87|0.79|
|[[:human_genes:A:ARID3A|ARID3A]]|1.88|0.79|
|[[:human_genes:B:BPIFB1|BPIFB1]]|1.88|0.79|
|[[:human_genes:P:PRPF31|PRPF31]]|1.89|0.79|
|[[:human_genes:D:DKK1|DKK1]]|1.90|0.77|
|[[:human_genes:C:CRABP2|CRABP2]]|1.92|0.74|
|[[:human_genes:C:CDKL3|CDKL3]]|1.92|0.79|
|[[:human_genes:C:CCDC120|CCDC120]]|1.95|0.79|
|[[:human_genes:G:GLRX2|GLRX2]]|1.96|0.64|
|[[:human_genes:T:TMEM79|TMEM79]]|2.00|0.60|
|[[:human_genes:C:CFAP45|CFAP45]]|2.03|0.89|
|[[:human_genes:C:CHD4|CHD4]]|2.03|0.79|
|[[:human_genes:R:RPL36|RPL36]]|2.05|0.80|
|[[:human_genes:P:PRPF19|PRPF19]]|2.06|0.79|
|[[:human_genes:Z:ZNF709|ZNF709]]|2.10|0.58|
|[[:human_genes:N:NIPBL|NIPBL]]|2.11|0.79|
|[[:human_genes:F:FARSB|FARSB]]|2.13|0.79|
|[[:human_genes:A:ACSS1|ACSS1]]|2.13|0.58|
|[[:human_genes:N:NAPA|NAPA]]|2.13|0.79|
|[[:human_genes:A:ATP6AP2|ATP6AP2]]|2.17|0.60|
|[[:human_genes:G:GLI3|GLI3]]|2.21|0.58|
|[[:human_genes:A:ABCA3|ABCA3]]|2.25|0.60|
|[[:human_genes:S:SYNE2|SYNE2]]|2.26|0.58|
|[[:human_genes:R:RACGAP1|RACGAP1]]|2.30|0.60|
|[[:human_genes:S:SPINK6|SPINK6]]|2.31|0.58|
|[[:human_genes:K:KRTAP10-3|KRTAP10-3]]|2.34|0.60|
|[[:human_genes:A:ALCAM|ALCAM]]|2.40|0.58|
|[[:human_genes:F:FBXW11|FBXW11]]|2.66|0.60|
|[[:human_genes:P:PSMD7|PSMD7]]|3.09|0.58|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>