Ethanol 0.003 R08 exp437 [The Human Chemical-Genetic Interaction Map Project]

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====== Ethanol 0.003 R08 exp437 ======
==== Mechanism of Action ====
Pleiotropic effects on membranes, ion channels, enzymes, receptors
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Solvent




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Ethanol%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 64-17-5
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/702|702]]
    * **<color #00a2e8>IUPAC:</color>** %%ethanol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3
    * **<color #00a2e8>INCHI Key:</color>** LFQSCWFLJHTTHZ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 46.07
    * **<color #00a2e8>Canonical SMILES:</color>** CCO
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C2H6O
{{:chemogenomics:structures:chem-0139.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Les Alcools de Commerce
    * **<color #00a2e8>Catalog #:</color>** P016EAAN
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** EtOH
    * **<color #00a2e8>Min:</color>** -9.0156; **<color #00a2e8>Max:</color>** 4.5158
{{:chemogenomics:dose_response:dr_222.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 0.3%
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.7
    * **<color #00a2e8>Numbers of reads</color>**: 16584745


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Ethanol_0.3pc_Round-8_exp437.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Ethanol 0.003 R08 exp437'>
{{:chemogenomics:cranks_plots:exp437.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:M:MS4A13|MS4A13]]|-2.90|0.62|
|[[:human_genes:A:ALG9|ALG9]]|-2.80|0.06|
|[[:human_genes:S:SPCS1|SPCS1]]|-2.76|0.08|
|[[:human_genes:U:UBE2J1|UBE2J1]]|-2.65|0.08|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.58|0.13|
|[[:human_genes:C:CERCAM|CERCAM]]|-2.41|0.13|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.28|0.49|
|[[:human_genes:C:COX17|COX17]]|-2.26|0.62|
|[[:human_genes:H:HSD17B12|HSD17B12]]|-2.08|0.62|
|[[:human_genes:C:CSK|CSK]]|-2.06|0.61|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.05|0.61|
|[[:human_genes:P:PDCD5|PDCD5]]|-2.03|0.61|
|[[:human_genes:N:NFATC1|NFATC1]]|-2.02|0.61|
|[[:human_genes:R:ROCK2|ROCK2]]|-2.02|0.62|
|[[:human_genes:U:UNC79|UNC79]]|-2.00|0.62|
|[[:human_genes:N:NAA15|NAA15]]|-1.99|0.62|
|[[:human_genes:I:IQGAP1|IQGAP1]]|-1.99|0.62|
|[[:human_genes:A:ALG6|ALG6]]|-1.97|0.62|
|[[:human_genes:E:EPHA5|EPHA5]]|-1.95|0.62|
|[[:human_genes:R:RGS9|RGS9]]|-1.94|0.62|
|[[:human_genes:F:FASTKD5|FASTKD5]]|-1.93|0.62|
|[[:human_genes:E:EPS8L3|EPS8L3]]|-1.93|0.62|
|[[:human_genes:E:ENTPD2|ENTPD2]]|-1.92|0.68|
|[[:human_genes:C:C7orf49|C7orf49]]|-1.92|0.62|
|[[:human_genes:U:USO1|USO1]]|-1.91|0.62|
|[[:human_genes:D:DBF4|DBF4]]|-1.90|0.62|
|[[:human_genes:K:KDM4C|KDM4C]]|-1.88|0.62|
|[[:human_genes:P:PROX1|PROX1]]|-1.87|0.62|
|[[:human_genes:W:WBSCR16|WBSCR16]]|-1.86|0.81|
|[[:human_genes:Z:ZBTB40|ZBTB40]]|-1.86|0.62|
|[[:human_genes:Z:ZC3H14|ZC3H14]]|1.86|0.90|
|[[:human_genes:R:RAD21L1|RAD21L1]]|1.87|0.90|
|[[:human_genes:C:C11orf74|C11orf74]]|1.89|0.90|
|[[:human_genes:U:UBA1|UBA1]]|1.89|0.92|
|[[:human_genes:P:PLK4|PLK4]]|1.90|0.90|
|[[:human_genes:O:OR52N2|OR52N2]]|1.90|0.90|
|[[:human_genes:S:SNPH|SNPH]]|1.91|0.90|
|[[:human_genes:I:IPO13|IPO13]]|1.94|0.90|
|[[:human_genes:P:PSMC2|PSMC2]]|1.94|0.90|
|[[:human_genes:A:ATP2B4|ATP2B4]]|1.96|0.90|
|[[:human_genes:N:NSA2|NSA2]]|1.96|0.91|
|[[:human_genes:C:C3orf20|C3orf20]]|1.97|0.90|
|[[:human_genes:O:OFD1|OFD1]]|1.98|0.90|
|[[:human_genes:E:EFTUD2|EFTUD2]]|2.02|0.90|
|[[:human_genes:G:GAR1|GAR1]]|2.07|0.90|
|[[:human_genes:E:EGR3|EGR3]]|2.08|0.90|
|[[:human_genes:D:DSG4|DSG4]]|2.11|0.90|
|[[:human_genes:C:COPB1|COPB1]]|2.13|0.90|
|[[:human_genes:U:USP39|USP39]]|2.15|0.90|
|[[:human_genes:C:CAD|CAD]]|2.16|0.90|
|[[:human_genes:C:CDC20|CDC20]]|2.16|0.90|
|[[:human_genes:P:PAFAH1B1|PAFAH1B1]]|2.18|0.91|
|[[:human_genes:R:RPL35A|RPL35A]]|2.18|0.92|
|[[:human_genes:S:SRSF3|SRSF3]]|2.22|0.90|
|[[:human_genes:C:CEBPZ|CEBPZ]]|2.29|0.90|
|[[:human_genes:O:OR4D11|OR4D11]]|2.30|0.64|
|[[:human_genes:N:NDC80|NDC80]]|2.42|0.90|
|[[:human_genes:P:PES1|PES1]]|2.46|0.90|
|[[:human_genes:T:TM9SF4|TM9SF4]]|2.54|0.30|
|[[:human_genes:L:LOC391322|LOC391322]]|2.70|0.90|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp219|A-395N 10μM R05 exp219]]|0.073|<button type="primary" size="small" modal="1">View</button>|
</modal>


<modal id="1" size="lg" title="A-395N 10μM R05 exp219  vs  Ethanol 0.003 R08 exp437">
{{:chemogenomics:comparison_plots:exp219_vs_exp437.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|oligosaccharide-lipid intermediate biosynthetic process|95.59|ALG9,DPAGT1,ALG6|
|dolichol metabolic process|91.04|ALG9,DPAGT1,ALG6|
|polyprenol metabolic process|83.12|ALG9,DPAGT1,ALG6|
|protein N-linked glycosylation|36.94|ALG9,UBE2J1,DPAGT1,ALG6|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>