NN-Diethyl-meta-toluamide 500μM R08 exp438 [The Human Chemical-Genetic Interaction Map Project]

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====== NN-Diethyl-meta-toluamide 500μM R08 exp438 ======
==== Mechanism of Action ====
Insect repellent
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Environmental Contaminant




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N,N-Diethyl-3-methylbenzamide%%
    * **<color #00a2e8>Synonyms:</color>** DEET; N,N-Diethyl-m-toluamide; DEET;N,N-Diethyl-m-toluamide
    * **<color #00a2e8>CAS #:</color>** 134-62-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/4284|4284]]
    * **<color #00a2e8>IUPAC:</color>** %%N,N-diethyl-3-methylbenzamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C12H17NO/c1-4-13(5-2)12(14)11-8-6-7-10(3)9-11/h6-9H,4-5H2,1-3H3
    * **<color #00a2e8>INCHI Key:</color>** MMOXZBCLCQITDF-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 191.27
    * **<color #00a2e8>Canonical SMILES:</color>** CCN(CC)C(=O)C1=CC=CC(=C1)C
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C4H13N3
{{:chemogenomics:structures:chem-0142.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-B0978
    * **<color #00a2e8>Lot #:</color>** 17164
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C12H17NO 192.13829; found 192.13825
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** DEET
    * **<color #00a2e8>Min:</color>** -26.1998; **<color #00a2e8>Max:</color>** 13.1558
{{:chemogenomics:dose_response:dr_522.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 500µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.8
    * **<color #00a2e8>Numbers of reads</color>**: 16765661


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/NN-Diethyl-meta-toluamide_500uM_Round-8_exp438.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='NN-Diethyl-meta-toluamide 500μM R08 exp438'>
{{:chemogenomics:cranks_plots:exp438.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:G:GPI|GPI]]|-3.02|0.22|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.69|0.12|
|[[:human_genes:Y:YARS|YARS]]|-2.62|0.33|
|[[:human_genes:N:NDUFS6|NDUFS6]]|-2.58|0.12|
|[[:human_genes:M:MBTPS2|MBTPS2]]|-2.37|0.22|
|[[:human_genes:R:REST|REST]]|-2.35|0.22|
|[[:human_genes:F:FAF2|FAF2]]|-2.32|0.27|
|[[:human_genes:L:LAMTOR3|LAMTOR3]]|-2.32|0.22|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.27|0.22|
|[[:human_genes:P:PCDHGC5|PCDHGC5]]|-2.22|0.26|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.21|0.26|
|[[:human_genes:C:CUL4A|CUL4A]]|-2.21|0.26|
|[[:human_genes:K:KDSR|KDSR]]|-2.19|0.26|
|[[:human_genes:K:KRTAP10-4|KRTAP10-4]]|-2.15|0.63|
|[[:human_genes:U:UNC79|UNC79]]|-2.15|0.45|
|[[:human_genes:F:FASTK|FASTK]]|-2.15|0.26|
|[[:human_genes:A:AHSP|AHSP]]|-2.14|0.26|
|[[:human_genes:A:ADSL|ADSL]]|-2.14|0.63|
|[[:human_genes:C:CCDC173|CCDC173]]|-2.11|0.26|
|[[:human_genes:C:CHKA|CHKA]]|-2.09|0.26|
|[[:human_genes:G:GDF9|GDF9]]|-2.09|0.26|
|[[:human_genes:E:EPHA8|EPHA8]]|-2.07|0.26|
|[[:human_genes:S:SLC5A12|SLC5A12]]|-2.07|0.26|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.06|0.26|
|[[:human_genes:P:POLG|POLG]]|-2.04|0.27|
|[[:human_genes:S:SLC16A12|SLC16A12]]|-2.03|0.27|
|[[:human_genes:M:MT1A|MT1A]]|-2.01|0.63|
|[[:human_genes:M:MRPL17|MRPL17]]|-1.98|0.63|
|[[:human_genes:U:UPRT|UPRT]]|-1.96|0.36|
|[[:human_genes:T:TRIP12|TRIP12]]|-1.93|0.39|
|[[:human_genes:Z:ZNF821|ZNF821]]|1.99|0.41|
|[[:human_genes:F:FABP12|FABP12]]|1.99|0.40|
|[[:human_genes:X:XAB2|XAB2]]|2.00|0.81|
|[[:human_genes:U:URB1|URB1]]|2.00|0.63|
|[[:human_genes:G:GOLGA3|GOLGA3]]|2.01|0.38|
|[[:human_genes:P:PKD1L3|PKD1L3]]|2.01|0.38|
|[[:human_genes:E:EXOSC9|EXOSC9]]|2.02|0.38|
|[[:human_genes:T:TMCO5A|TMCO5A]]|2.02|0.41|
|[[:human_genes:Z:ZNF654|ZNF654]]|2.04|0.38|
|[[:human_genes:T:TSPYL1|TSPYL1]]|2.04|0.47|
|[[:human_genes:C:CCNA2|CCNA2]]|2.06|0.46|
|[[:human_genes:L:LMTK3|LMTK3]]|2.06|0.46|
|[[:human_genes:C:C19orf33|C19orf33]]|2.09|0.33|
|[[:human_genes:U:UBE4B|UBE4B]]|2.12|0.33|
|[[:human_genes:P:PDS5B|PDS5B]]|2.17|0.30|
|[[:human_genes:C:CCND3|CCND3]]|2.18|0.62|
|[[:human_genes:C:CFAP45|CFAP45]]|2.20|0.75|
|[[:human_genes:F:FAM53C|FAM53C]]|2.22|0.33|
|[[:human_genes:Z:ZNF335|ZNF335]]|2.26|0.54|
|[[:human_genes:M:MPHOSPH10|MPHOSPH10]]|2.27|0.41|
|[[:human_genes:G:GPR50|GPR50]]|2.27|0.19|
|[[:human_genes:C:C4BPA|C4BPA]]|2.28|0.19|
|[[:human_genes:P:PHF1|PHF1]]|2.28|0.31|
|[[:human_genes:E:EIF3A|EIF3A]]|2.29|0.19|
|[[:human_genes:S:SKIV2L|SKIV2L]]|2.31|0.38|
|[[:human_genes:G:GID4|GID4]]|2.34|0.19|
|[[:human_genes:K:KCTD15|KCTD15]]|2.39|0.19|
|[[:human_genes:E:EIF3G|EIF3G]]|2.47|0.19|
|[[:human_genes:E:ERMP1|ERMP1]]|2.53|0.19|
|[[:human_genes:T:TBRG4|TBRG4]]|2.64|0.19|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|0.06|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.056|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp224|CB-839 10μM R05 exp224]]|0.055|<button type="primary" size="small" modal="3">View</button>|
</modal>


<modal id="1" size="lg" title="Cincreasin 100μM R08 exp473  vs  NN-Diethyl-meta-toluamide 500μM R08 exp438">
{{:chemogenomics:comparison_plots:exp438_vs_exp473.png?nolink |}}
</modal>

<modal id="2" size="lg" title="B02 10μM R08 exp453  vs  NN-Diethyl-meta-toluamide 500μM R08 exp438">
{{:chemogenomics:comparison_plots:exp438_vs_exp453.png?nolink |}}
</modal>

<modal id="3" size="lg" title="CB-839 10μM R05 exp224  vs  NN-Diethyl-meta-toluamide 500μM R08 exp438">
{{:chemogenomics:comparison_plots:exp224_vs_exp438.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|CDP-choline pathway|306.83|CEPT1,CHKA,PCYT1A|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|ribonucleoprotein complex biogenesis|10.30|EIF3G,EIF3A,MPHOSPH10,EXOSC9,URB1,XAB2,RPL14,CRNKL1|
</modal>