Ammonium tetrathiomolybdate 10μM R08 exp448 [The Human Chemical-Genetic Interaction Map Project]

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====== Ammonium tetrathiomolybdate 10μM R08 exp448 ======
==== Mechanism of Action ====
Inhibits cuproenzymes superoxide dismutase 1 (SOD1) and cytochrome c oxidase (COX)
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Metal Chelator
  * **<color #00a2e8>Class / Subclass 2:</color>** Metabolism / Metabolic Enzyme Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Ammonium tetrathiomolybdate%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 15060-55-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/15251598|15251598]]
    * **<color #00a2e8>IUPAC:</color>** %%diazanium;bis(sulfanylidene)molybdenum;sulfanide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/Mo.2H3N.2H2S.2S/h;2*1H3;2*1H2;;
    * **<color #00a2e8>INCHI Key:</color>** ZKKLPDLKUGTPME-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 262.3
    * **<color #00a2e8>Canonical SMILES:</color>** [NH4+].[NH4+].[SH-].[SH-].S=[Mo]=S
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** H10MoN2S4
{{:chemogenomics:structures:chem-0259.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** 323446
    * **<color #00a2e8>Lot #:</color>** MKCG8991
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>XRPD:</color>** Expected (NH4)2MoS4; found (NH4)2MoS4
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** AMTT
    * **<color #00a2e8>Min:</color>** -10.9997; **<color #00a2e8>Max:</color>** 86.4825
{{:chemogenomics:dose_response:dr_497.png?nolink&500 |}}
\\ 
\\ 
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.6222    |
| IC20  |1.7960    |
| IC30  |3.6350    |
| IC40  |6.4770    |
| IC50  |11.0100    |
| IC60  |18.7000    |
| IC70  |33.3300    |
| IC80  |67.4300    |
| IC90  |194.7000    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 10µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.4
    * **<color #00a2e8>Numbers of reads</color>**: 16291905


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/35|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Ammonium_tetrathiomolybdate_10uM_Round-8_exp448.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Ammonium tetrathiomolybdate 10μM R08 exp448'>
{{:chemogenomics:cranks_plots:exp448.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PSMA7|PSMA7]]|-3.19|0.20|
|[[:human_genes:E:EIF3B|EIF3B]]|-2.70|0.43|
|[[:human_genes:C:COPB1|COPB1]]|-2.64|0.43|
|[[:human_genes:A:ATP6V0B|ATP6V0B]]|-2.64|0.46|
|[[:human_genes:A:ATP6AP1|ATP6AP1]]|-2.48|0.50|
|[[:human_genes:P:PDGFC|PDGFC]]|-2.41|0.24|
|[[:human_genes:S:SLC29A1|SLC29A1]]|-2.40|0.24|
|[[:human_genes:P:PLK1|PLK1]]|-2.39|0.50|
|[[:human_genes:D:DDX21|DDX21]]|-2.38|0.46|
|[[:human_genes:P:PRDM4|PRDM4]]|-2.34|0.26|
|[[:human_genes:D:DHX38|DHX38]]|-2.33|0.46|
|[[:human_genes:U:UACA|UACA]]|-2.30|0.26|
|[[:human_genes:P:POLA1|POLA1]]|-2.29|0.47|
|[[:human_genes:D:DDX46|DDX46]]|-2.28|0.52|
|[[:human_genes:C:CDC73|CDC73]]|-2.27|0.43|
|[[:human_genes:C:CARF|CARF]]|-2.26|0.41|
|[[:human_genes:R:RPS11|RPS11]]|-2.24|0.46|
|[[:human_genes:P:PLK4|PLK4]]|-2.22|0.43|
|[[:human_genes:T:TINF2|TINF2]]|-2.22|0.43|
|[[:human_genes:I:IAPP|IAPP]]|-2.20|0.39|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-2.16|0.41|
|[[:human_genes:G:GOLGA6L1|GOLGA6L1]]|-2.16|0.62|
|[[:human_genes:H:HMGCR|HMGCR]]|-2.16|0.50|
|[[:human_genes:E:EEFSEC|EEFSEC]]|-2.12|0.41|
|[[:human_genes:C:CHMP2A|CHMP2A]]|-2.12|0.47|
|[[:human_genes:G:GOLGA6L6|GOLGA6L6]]|-2.11|0.46|
|[[:human_genes:N:NKX6-1|NKX6-1]]|-2.11|0.46|
|[[:human_genes:P:POLR1D|POLR1D]]|-2.10|0.43|
|[[:human_genes:S:SEPHS2|SEPHS2]]|-2.08|0.43|
|[[:human_genes:N:NUPL1|NUPL1]]|-2.08|0.43|
|[[:human_genes:T:TP53|TP53]]|2.60|0.02|
|[[:human_genes:C:COQ3|COQ3]]|2.68|<0.01|
|[[:human_genes:A:ATP5A1|ATP5A1]]|2.68|0.03|
|[[:human_genes:N:NDUFA2|NDUFA2]]|2.69|0.01|
|[[:human_genes:M:MFSD9|MFSD9]]|2.79|<0.01|
|[[:human_genes:T:TKT|TKT]]|2.81|0.01|
|[[:human_genes:C:COQ5|COQ5]]|2.82|<0.01|
|[[:human_genes:F:FASTKD1|FASTKD1]]|2.90|<0.01|
|[[:human_genes:D:DOHH|DOHH]]|2.93|<0.01|
|[[:human_genes:T:TAZ|TAZ]]|3.05|0.04|
|[[:human_genes:P:PPP6C|PPP6C]]|3.13|<0.01|
|[[:human_genes:U:UQCRC1|UQCRC1]]|3.14|<0.01|
|[[:human_genes:C:COQ6|COQ6]]|3.14|<0.01|
|[[:human_genes:C:COQ2|COQ2]]|3.14|<0.01|
|[[:human_genes:M:MED16|MED16]]|3.19|<0.01|
|[[:human_genes:M:ME2|ME2]]|3.27|0.00|
|[[:human_genes:C:COQ4|COQ4]]|3.31|0.00|
|[[:human_genes:U:UQCRQ|UQCRQ]]|3.43|0.00|
|[[:human_genes:A:AASDHPPT|AASDHPPT]]|3.45|0.00|
|[[:human_genes:C:COQ7|COQ7]]|3.51|0.00|
|[[:human_genes:M:MBTPS2|MBTPS2]]|3.53|0.00|
|[[:human_genes:P:PDSS2|PDSS2]]|3.54|0.00|
|[[:human_genes:B:BAK1|BAK1]]|3.63|0.00|
|[[:human_genes:U:UQCC1|UQCC1]]|3.68|0.00|
|[[:human_genes:B:BCS1L|BCS1L]]|3.74|0.00|
|[[:human_genes:U:UQCRC2|UQCRC2]]|3.77|0.00|
|[[:human_genes:P:PDSS1|PDSS1]]|3.80|0.00|
|[[:human_genes:U:UQCC2|UQCC2]]|4.40|0.00|
|[[:human_genes:A:ATOX1|ATOX1]]|6.64|0.00|
|[[:human_genes:A:ATP7A|ATP7A]]|8.49|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.136|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.091|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.085|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.083|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.081|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|0.079|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.078|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.077|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.076|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.075|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.073|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.071|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.071|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|0.07|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp532|TIC10 10μM R08 exp532]]|0.07|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|0.066|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.063|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.063|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.062|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.062|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.06|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.06|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.056|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.055|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.054|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.052|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.052|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.078|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.065|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.059|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.053|<button type="primary" size="small" modal="31">View</button>|
</modal>


<modal id="1" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Atovaquone 15μM R08 exp451">
{{:chemogenomics:comparison_plots:exp448_vs_exp451.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Vinblastine 0.2μM R03 exp108">
{{:chemogenomics:comparison_plots:exp108_vs_exp448.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Bleomycin 5μM R08 exp459">
{{:chemogenomics:comparison_plots:exp448_vs_exp459.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp448_vs_exp527.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp448_vs_exp478.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Hinokiflavone 12μM R08 exp487">
{{:chemogenomics:comparison_plots:exp448_vs_exp487.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  GSK461364A 0.1μM R03 exp126">
{{:chemogenomics:comparison_plots:exp126_vs_exp448.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  CI-1040 9.5μM R08 exp472">
{{:chemogenomics:comparison_plots:exp448_vs_exp472.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp448.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Benzoate 20000μM R08 exp456">
{{:chemogenomics:comparison_plots:exp448_vs_exp456.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp448_vs_exp450.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp440_vs_exp448.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  BI-2536 0.02μM R03 exp96">
{{:chemogenomics:comparison_plots:exp448_vs_exp96.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Monensin 0.3μM R08 exp507">
{{:chemogenomics:comparison_plots:exp448_vs_exp507.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  TIC10 10μM R08 exp532">
{{:chemogenomics:comparison_plots:exp448_vs_exp532.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  ONC212 0.15μM R08 exp513">
{{:chemogenomics:comparison_plots:exp448_vs_exp513.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp448_vs_exp503.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp448.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp448_vs_exp531.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp448.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  GSK-J4 1.5μM R08 exp441">
{{:chemogenomics:comparison_plots:exp441_vs_exp448.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp448.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  BI-6727 0.04μM R03 exp98">
{{:chemogenomics:comparison_plots:exp448_vs_exp98.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp448_vs_exp474.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  MLN-4924 2μM R00 exp22">
{{:chemogenomics:comparison_plots:exp22_vs_exp448.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp448_vs_exp515.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp448_vs_exp489.png?nolink |}}
</modal>

<modal id="28" size="lg" title="42°C R08 exp539  vs  Ammonium tetrathiomolybdate 10μM R08 exp448">
{{:chemogenomics:comparison_plots:exp448_vs_exp539.png?nolink |}}
</modal>

<modal id="29" size="lg" title="AICAR 240μM R05 exp211  vs  Ammonium tetrathiomolybdate 10μM R08 exp448">
{{:chemogenomics:comparison_plots:exp211_vs_exp448.png?nolink |}}
</modal>

<modal id="30" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Ammonium tetrathiomolybdate 10μM R08 exp448">
{{:chemogenomics:comparison_plots:exp2_vs_exp448.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Ammonium tetrathiomolybdate 10μM R08 exp448">
{{:chemogenomics:comparison_plots:exp3_vs_exp448.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|ubiquinone biosynthesis complex|552.30|COQ7,COQ4,COQ6,COQ5,COQ3|
|extrinsic component of mitochondrial inner membrane|368.20|COQ7,COQ4,COQ5,COQ3|
|ubiquinone biosynthetic process|294.56|PDSS1,PDSS2,COQ7,COQ4,COQ2,COQ6,COQ5,COQ3|
|ubiquinone metabolic process|259.91|PDSS1,PDSS2,COQ7,COQ4,COQ2,COQ6,COQ5,COQ3|
|quinone biosynthetic process|257.74|PDSS1,PDSS2,COQ4,COQ2,COQ6,COQ5,COQ3|
|respiratory chain complex III|245.47|UQCRC2,BCS1L,UQCRQ,UQCRC1|
|ketone biosynthetic process|157.80|PDSS1,PDSS2,COQ7,COQ4,COQ2,COQ6,COQ5,COQ3|
|quinone metabolic process|119.42|PDSS1,PDSS2,COQ7,COQ4,COQ2,COQ6,COQ5,COQ3|
|extrinsic component of organelle membrane|102.28|COQ7,COQ4,COQ6,COQ5,COQ3|
|cellular ketone metabolic process|52.60|PDSS1,PDSS2,COQ7,COQ4,COQ2,COQ6,COQ5,COQ3|
|respiratory chain complex|44.78|UQCRC2,BCS1L,UQCRQ,UQCRC1,NDUFA2,NDUFB11|
|mitochondrial respirasome|44.18|UQCRC2,BCS1L,UQCRQ,UQCRC1,NDUFA2,NDUFB11|
|respirasome|40.41|UQCRC2,BCS1L,UQCRQ,UQCRC1,NDUFA2,NDUFB11|
|inner mitochondrial membrane protein complex|29.29|UQCRC2,BCS1L,UQCRQ,UQCRC1,NDUFA2,ATP5F1A,NDUFB11|
|mitochondrial inner membrane|18.09|UQCC2,UQCRC2,BCS1L,UQCC1,COQ7,UQCRQ,COQ4,COQ2,COQ6,UQCRC1,COQ5,NDUFA2,ATP5F1A,COQ3,NDUFB11|
|organelle inner membrane|16.24|UQCC2,UQCRC2,BCS1L,UQCC1,COQ7,UQCRQ,COQ4,COQ2,COQ6,UQCRC1,COQ5,NDUFA2,ATP5F1A,COQ3,NDUFB11|
|mitochondrial membrane|13.32|UQCC2,UQCRC2,BCS1L,UQCC1,BAK1,COQ7,UQCRQ,COQ4,COQ2,COQ6,UQCRC1,COQ5,NDUFA2,ATP5F1A,COQ3,VDAC2,NDUFB11|
|mitochondrial envelope|12.50|UQCC2,UQCRC2,BCS1L,UQCC1,BAK1,COQ7,UQCRQ,COQ4,COQ2,COQ6,UQCRC1,COQ5,NDUFA2,ATP5F1A,COQ3,VDAC2,NDUFB11|
|mitochondrial matrix|11.65|UQCC2,PDSS1,PDSS2,ME2,FASTKD1,COQ5,ATP5F1A,COQ3,TP53,VDAC2|
</modal>