Bisphenol S 100μM R08 exp458 [The Human Chemical-Genetic Interaction Map Project]

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====== Bisphenol S 100μM R08 exp458 ======
==== Mechanism of Action ====
BPA analog and substitute in BPA-free plastics, endocrine disrupter
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Industrial Chemical




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%4,4'-Sulfonyldiphenol%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 80-09-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/6626|6626]]
    * **<color #00a2e8>IUPAC:</color>** %%4-(4-hydroxyphenyl)sulfonylphenol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C12H10O4S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8,13-14H
    * **<color #00a2e8>INCHI Key:</color>** VPWNQTHUCYMVMZ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 250.27
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=CC=C1O)S(=O)(=O)C2=CC=C(C=C2)O
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C12H10O4S
{{:chemogenomics:structures:chem-0268.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Ark Pharm Inc.
    * **<color #00a2e8>Catalog #:</color>** AK112768
    * **<color #00a2e8>Lot #:</color>** WG0022663-160824001
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C12H10O4S 251.03726; found 251.03703
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Bisphenol_S
    * **<color #00a2e8>Min:</color>** -9.1579; **<color #00a2e8>Max:</color>** 15.4679
{{:chemogenomics:dose_response:dr_419.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 100µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 4.6
    * **<color #00a2e8>Numbers of reads</color>**: 14220037


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/2|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Bisphenol_S_100uM_Round-8_exp458.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Bisphenol S 100μM R08 exp458'>
{{:chemogenomics:cranks_plots:exp458.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:M:MCM9|MCM9]]|-2.69|0.15|
|[[:human_genes:S:SWI5|SWI5]]|-2.51|0.15|
|[[:human_genes:A:ALG3|ALG3]]|-2.40|0.15|
|[[:human_genes:F:FAM50A|FAM50A]]|-2.39|0.60|
|[[:human_genes:M:MPDU1|MPDU1]]|-2.38|0.18|
|[[:human_genes:A:ALG9|ALG9]]|-2.37|0.15|
|[[:human_genes:A:ALG5|ALG5]]|-2.37|0.15|
|[[:human_genes:D:DPM3|DPM3]]|-2.36|0.15|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-2.28|0.18|
|[[:human_genes:H:HMBOX1|HMBOX1]]|-2.23|0.18|
|[[:human_genes:L:LEO1|LEO1]]|-2.23|0.18|
|[[:human_genes:C:CSK|CSK]]|-2.22|0.18|
|[[:human_genes:D:DPM1|DPM1]]|-2.15|0.39|
|[[:human_genes:A:A1CF|A1CF]]|-2.13|0.39|
|[[:human_genes:B:BTBD9|BTBD9]]|-2.13|0.39|
|[[:human_genes:T:TOMM7|TOMM7]]|-2.10|0.33|
|[[:human_genes:B:BCL2|BCL2]]|-2.06|0.38|
|[[:human_genes:R:RAPH1|RAPH1]]|-2.05|0.38|
|[[:human_genes:R:RBMX2|RBMX2]]|-2.04|0.43|
|[[:human_genes:C:CNOT11|CNOT11]]|-2.02|0.53|
|[[:human_genes:S:SLC25A23|SLC25A23]]|-2.00|0.46|
|[[:human_genes:P:PTEN|PTEN]]|-1.98|0.41|
|[[:human_genes:Y:YES1|YES1]]|-1.97|0.41|
|[[:human_genes:U:UPF3B|UPF3B]]|-1.97|0.41|
|[[:human_genes:G:GSK3B|GSK3B]]|-1.95|0.43|
|[[:human_genes:T:TRIAP1|TRIAP1]]|-1.93|0.58|
|[[:human_genes:T:TBCA|TBCA]]|-1.93|0.43|
|[[:human_genes:R:RAD51B|RAD51B]]|-1.92|0.53|
|[[:human_genes:F:FOXK1|FOXK1]]|-1.92|0.43|
|[[:human_genes:Z:ZNF232|ZNF232]]|-1.92|0.43|
|[[:human_genes:Z:ZNF727|ZNF727]]|2.03|0.29|
|[[:human_genes:D:DDX18|DDX18]]|2.03|0.47|
|[[:human_genes:A:ARL6IP4|ARL6IP4]]|2.03|0.47|
|[[:human_genes:S:STAC2|STAC2]]|2.05|0.27|
|[[:human_genes:C:CCL5|CCL5]]|2.06|0.27|
|[[:human_genes:A:ATP6AP1|ATP6AP1]]|2.09|0.69|
|[[:human_genes:R:RPL8|RPL8]]|2.10|0.76|
|[[:human_genes:K:KIAA1429|KIAA1429]]|2.10|0.51|
|[[:human_genes:Z:ZNF148|ZNF148]]|2.11|0.24|
|[[:human_genes:E:ESM1|ESM1]]|2.12|0.24|
|[[:human_genes:U:UQCC2|UQCC2]]|2.14|0.29|
|[[:human_genes:C:CCNL1|CCNL1]]|2.15|0.24|
|[[:human_genes:P:PDS5A|PDS5A]]|2.16|0.24|
|[[:human_genes:T:TIPRL|TIPRL]]|2.20|0.23|
|[[:human_genes:M:MS4A13|MS4A13]]|2.24|0.71|
|[[:human_genes:C:CXorf56|CXorf56]]|2.25|0.24|
|[[:human_genes:C:CD19|CD19]]|2.26|0.24|
|[[:human_genes:M:METTL14|METTL14]]|2.27|0.46|
|[[:human_genes:J:JMJD6|JMJD6]]|2.29|0.15|
|[[:human_genes:C:CITED2|CITED2]]|2.30|0.15|
|[[:human_genes:S:SLC35F3|SLC35F3]]|2.36|0.15|
|[[:human_genes:G:GTF2E2|GTF2E2]]|2.36|0.25|
|[[:human_genes:G:GAGE2A|GAGE2A]]|2.36|0.61|
|[[:human_genes:M:MFAP1|MFAP1]]|2.43|0.15|
|[[:human_genes:R:RPL36|RPL36]]|2.55|0.24|
|[[:human_genes:O:ODC1|ODC1]]|2.63|0.06|
|[[:human_genes:P:PPWD1|PPWD1]]|2.70|0.15|
|[[:human_genes:T:TMEM187|TMEM187]]|2.96|0.03|
|[[:human_genes:E:EXOSC7|EXOSC7]]|3.02|0.11|
|[[:human_genes:R:RBM26|RBM26]]|3.07|0.03|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|dolichol-linked oligosaccharide biosynthetic process|120.28|ALG3,MPDU1,ALG9,DPM1|
|oligosaccharide-lipid intermediate biosynthetic process|114.27|ALG3,MPDU1,ALG9,DPM1|
|dolichol metabolic process|108.83|ALG3,MPDU1,ALG9,DPM3|
|polyprenol metabolic process|99.36|MPDU1,ALG9,DPM3,DPM1|
|protein N-linked glycosylation|41.40|ALG3,MPDU1,ALG9,ALG5,DPM1|
|isoprenoid metabolic process|22.32|ALG3,MPDU1,ALG9,DPM3,DPM1|
|protein glycosylation|18.53|ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1|
|macromolecule glycosylation|18.53|ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1|
|glycosylation|16.48|ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1|
|glycoprotein biosynthetic process|13.71|ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1|
|glycoprotein metabolic process|10.92|ALG3,MPDU1,ALG9,ALG5,DPM3,DPM1|
|alcohol metabolic process|10.81|ALG3,MPDU1,ALG9,DPM3,PRKAA1,DPM1|
|organic hydroxy compound metabolic process|9.66|ALG3,MPDU1,ALG9,DPM3,PRKAA1,DPM1,BTBD9,BCL2|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|RNA splicing|10.71|PPWD1,MFAP1,JMJD6,METTL14,VIRMA,ARL6IP4,USP39|
|mRNA processing|10.20|RBM26,PPWD1,MFAP1,JMJD6,METTL14,VIRMA,ARL6IP4,USP39|
|mRNA metabolic process|8.44|RBM26,EXOSC7,PPWD1,MFAP1,JMJD6,METTL14,VIRMA,ARL6IP4,USP39|
|RNA processing|6.65|RBM26,EXOSC7,PPWD1,MFAP1,JMJD6,METTL14,VIRMA,ARL6IP4,DDX18,USP39|
</modal>