Cadmium 60μM R08 exp462 [The Human Chemical-Genetic Interaction Map Project]

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====== Cadmium 60μM R08 exp462 ======
==== Mechanism of Action ====
Widely used metal in manufacturing and pigments, known carcinogen
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Heavy Metal




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Cadmium chloride%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 10108-64-2
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/24947|24947]]
    * **<color #00a2e8>IUPAC:</color>** %%dichlorocadmium%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/Cd.2ClH/h;2*1H/q+2;;/p-2
    * **<color #00a2e8>INCHI Key:</color>** YKYOUMDCQGMQQO-UHFFFAOYSA-L
    * **<color #00a2e8>Molecular Weight:</color>** 183.32
    * **<color #00a2e8>Canonical SMILES:</color>** Cl[Cd]Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** CdCl2
{{:chemogenomics:structures:chem-0272.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** C059000
    * **<color #00a2e8>Lot #:</color>** 28-GHZ-35-1
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>XRPD:</color>** Expected CdCl2; found CdCl2 2H2O
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Cadmium
    * **<color #00a2e8>Min:</color>** 16.9919; **<color #00a2e8>Max:</color>** 99.9797
{{:chemogenomics:dose_response:dr_602.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |55.4100    |
| IC20  |59.1100    |
| IC30  |61.7000    |
| IC40  |63.9100    |
| IC50  |66.0100    |
| IC60  |68.1800    |
| IC70  |70.6200    |
| IC80  |73.7200    |
| IC90  |78.6500    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 60µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.7
    * **<color #00a2e8>Numbers of reads</color>**: 14757519


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|8/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Cadmium_60uM_Round-8_exp462.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Cadmium 60μM R08 exp462'>
{{:chemogenomics:cranks_plots:exp462.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:M:MT1G|MT1G]]|-3.58|0.01|
|[[:human_genes:M:MT1F|MT1F]]|-3.12|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|-3.06|0.02|
|[[:human_genes:M:MT1X|MT1X]]|-2.99|<0.01|
|[[:human_genes:M:MT2A|MT2A]]|-2.76|0.02|
|[[:human_genes:S:SLC39A10|SLC39A10]]|-2.65|0.02|
|[[:human_genes:S:SSB|SSB]]|-2.65|0.02|
|[[:human_genes:M:MOCS3|MOCS3]]|-2.53|0.15|
|[[:human_genes:R:RER1|RER1]]|-2.48|0.05|
|[[:human_genes:M:MED25|MED25]]|-2.43|0.17|
|[[:human_genes:L:LY96|LY96]]|-2.34|0.27|
|[[:human_genes:L:LOC391322|LOC391322]]|-2.30|0.71|
|[[:human_genes:K:KCTD15|KCTD15]]|-2.29|0.13|
|[[:human_genes:K:KIDINS220|KIDINS220]]|-2.29|0.13|
|[[:human_genes:M:MOSPD2|MOSPD2]]|-2.24|0.15|
|[[:human_genes:M:MTF1|MTF1]]|-2.23|0.17|
|[[:human_genes:M:MT1H|MT1H]]|-2.19|0.37|
|[[:human_genes:T:TBX21|TBX21]]|-2.19|0.16|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|-2.18|0.16|
|[[:human_genes:M:MPHOSPH8|MPHOSPH8]]|-2.17|0.16|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.17|0.16|
|[[:human_genes:V:VPS13C|VPS13C]]|-2.15|0.17|
|[[:human_genes:R:RBM26|RBM26]]|-2.13|0.22|
|[[:human_genes:S:SLC25A19|SLC25A19]]|-2.12|0.17|
|[[:human_genes:U:UBE2N|UBE2N]]|-2.11|0.17|
|[[:human_genes:C:C8orf22|C8orf22]]|-2.11|0.17|
|[[:human_genes:U:UFC1|UFC1]]|-2.11|0.17|
|[[:human_genes:Z:ZNF544|ZNF544]]|-2.08|0.18|
|[[:human_genes:K:KRTAP5-1|KRTAP5-1]]|-2.07|0.18|
|[[:human_genes:U:UBE2G2|UBE2G2]]|-2.07|0.24|
|[[:human_genes:N:NYAP1|NYAP1]]|1.89|0.69|
|[[:human_genes:R:RSBN1|RSBN1]]|1.90|0.69|
|[[:human_genes:N:NPIPA2|NPIPA2]]|1.91|0.71|
|[[:human_genes:F:FUT10|FUT10]]|1.92|0.69|
|[[:human_genes:N:NHP2L1|NHP2L1]]|1.92|0.71|
|[[:human_genes:K:KCNH5|KCNH5]]|1.93|0.69|
|[[:human_genes:T:THOC2|THOC2]]|1.93|0.69|
|[[:human_genes:I:INTS4|INTS4]]|1.94|0.69|
|[[:human_genes:S:SH3BP1|SH3BP1]]|1.94|0.69|
|[[:human_genes:S:SNRPG|SNRPG]]|1.94|0.80|
|[[:human_genes:G:GTF2F1|GTF2F1]]|1.95|0.69|
|[[:human_genes:C:CREBZF|CREBZF]]|1.95|0.69|
|[[:human_genes:N:NARFL|NARFL]]|1.95|0.73|
|[[:human_genes:S:SMG1|SMG1]]|1.97|0.69|
|[[:human_genes:C:CDX2|CDX2]]|1.98|0.69|
|[[:human_genes:S:SRGAP2C|SRGAP2C]]|1.98|0.71|
|[[:human_genes:P:PES1|PES1]]|1.99|0.71|
|[[:human_genes:N:NGDN|NGDN]]|2.09|0.71|
|[[:human_genes:C:CDC45|CDC45]]|2.12|0.69|
|[[:human_genes:R:RBM22|RBM22]]|2.12|0.69|
|[[:human_genes:P:PLRG1|PLRG1]]|2.22|0.53|
|[[:human_genes:S:SLC30A5|SLC30A5]]|2.22|0.35|
|[[:human_genes:P:PSMA3|PSMA3]]|2.25|0.69|
|[[:human_genes:M:MST1L|MST1L]]|2.28|0.44|
|[[:human_genes:A:ALDOC|ALDOC]]|2.47|0.16|
|[[:human_genes:F:FAM231A|FAM231A]]|2.53|0.16|
|[[:human_genes:F:FAM231C|FAM231C]]|2.53|0.16|
|[[:human_genes:C:CEP192|CEP192]]|2.78|0.16|
|[[:human_genes:M:MRGPRX3|MRGPRX3]]|2.82|0.06|
|[[:human_genes:M:MS4A13|MS4A13]]|2.94|0.69|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>