Cannabidiol 20μM R08 exp466 [The Human Chemical-Genetic Interaction Map Project]

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====== Cannabidiol 20μM R08 exp466 ======
==== Mechanism of Action ====
Negative allosteric modulator of cannabinoid CB1 receptor
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Psychoactive Drug
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / GPCR Antagonist



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Cannabidiol%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 13956-29-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/644019|644019]]
    * **<color #00a2e8>IUPAC:</color>** %%2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** QHMBSVQNZZTUGM-ZWKOTPCHSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 314.5
    * **<color #00a2e8>Canonical SMILES:</color>** CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O
    * **<color #00a2e8>Isomeric SMILES:</color>** CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O
    * **<color #00a2e8>Molecular Formula:</color>** C21H30O2
{{:chemogenomics:structures:chem-0275.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** C175300
    * **<color #00a2e8>Lot #:</color>** 9-RIT-154-2
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>LCMS:</color>** Tr 1.38 min, m/z 315+ [M+H]+, 313- [M-H]-
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** CBD
    * **<color #00a2e8>Min:</color>** -4.3129; **<color #00a2e8>Max:</color>** 99.8419
{{:chemogenomics:dose_response:dr_606.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |7.8520    |
| IC20  |10.4800    |
| IC30  |12.6900    |
| IC40  |14.8500    |
| IC50  |17.1600    |
| IC60  |19.8200    |
| IC70  |23.1900    |
| IC80  |28.0900    |
| IC90  |37.4800    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 20µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.9
    * **<color #00a2e8>Numbers of reads</color>**: 13942379


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|28/24|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Cannabidiol_20uM_Round-8_exp466.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Cannabidiol 20μM R08 exp466'>
{{:chemogenomics:cranks_plots:exp466.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PTDSS2|PTDSS2]]|-3.76|<0.01|
|[[:human_genes:A:ATP6V0E1|ATP6V0E1]]|-3.33|<0.01|
|[[:human_genes:M:MMGT1|MMGT1]]|-3.22|<0.01|
|[[:human_genes:T:TCF3|TCF3]]|-3.21|<0.01|
|[[:human_genes:G:GPR107|GPR107]]|-3.16|<0.01|
|[[:human_genes:E:EPT1|EPT1]]|-3.10|<0.01|
|[[:human_genes:P:PCYT2|PCYT2]]|-3.00|<0.01|
|[[:human_genes:A:ATP6V0B|ATP6V0B]]|-2.99|0.17|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.98|<0.01|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-2.79|<0.01|
|[[:human_genes:C:CANX|CANX]]|-2.78|0.01|
|[[:human_genes:T:TSC1|TSC1]]|-2.76|0.01|
|[[:human_genes:C:CCDC47|CCDC47]]|-2.73|<0.01|
|[[:human_genes:T:TRAPPC13|TRAPPC13]]|-2.70|0.01|
|[[:human_genes:R:RPL18|RPL18]]|-2.67|0.42|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.67|0.01|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-2.65|0.01|
|[[:human_genes:U:UBE2A|UBE2A]]|-2.65|0.01|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.63|0.01|
|[[:human_genes:S:SMIM11A|SMIM11A]]|-2.62|0.29|
|[[:human_genes:L:LPGAT1|LPGAT1]]|-2.61|0.01|
|[[:human_genes:T:TCF4|TCF4]]|-2.61|0.01|
|[[:human_genes:C:C18orf32|C18orf32]]|-2.57|0.31|
|[[:human_genes:W:WDR11|WDR11]]|-2.56|0.03|
|[[:human_genes:N:NCLN|NCLN]]|-2.55|0.03|
|[[:human_genes:J:JTB|JTB]]|-2.55|0.01|
|[[:human_genes:K:KAT7|KAT7]]|-2.54|0.01|
|[[:human_genes:R:RBM5|RBM5]]|-2.51|0.01|
|[[:human_genes:B:BECN1|BECN1]]|-2.50|0.01|
|[[:human_genes:Y:YRDC|YRDC]]|-2.47|0.26|
|[[:human_genes:O:OAZ1|OAZ1]]|2.22|0.07|
|[[:human_genes:S:SELRC1|SELRC1]]|2.23|0.07|
|[[:human_genes:E:EIF4A1|EIF4A1]]|2.26|0.10|
|[[:human_genes:T:TXNDC9|TXNDC9]]|2.33|0.04|
|[[:human_genes:C:CHD7|CHD7]]|2.36|0.07|
|[[:human_genes:P:PPP6C|PPP6C]]|2.37|0.07|
|[[:human_genes:T:TECTB|TECTB]]|2.40|0.04|
|[[:human_genes:Z:ZNHIT1|ZNHIT1]]|2.42|0.06|
|[[:human_genes:G:GCLC|GCLC]]|2.45|0.03|
|[[:human_genes:Z:ZCRB1|ZCRB1]]|2.46|0.05|
|[[:human_genes:S:SRM|SRM]]|2.49|0.02|
|[[:human_genes:A:ATP5I|ATP5I]]|2.53|0.02|
|[[:human_genes:S:SLC25A19|SLC25A19]]|2.58|0.01|
|[[:human_genes:G:G6PD|G6PD]]|2.59|0.01|
|[[:human_genes:A:ALDH8A1|ALDH8A1]]|2.60|0.01|
|[[:human_genes:I:IKZF1|IKZF1]]|2.62|0.01|
|[[:human_genes:G:GATAD2B|GATAD2B]]|2.64|0.01|
|[[:human_genes:R:RPP21|RPP21]]|2.64|0.04|
|[[:human_genes:I:ID4|ID4]]|2.66|0.01|
|[[:human_genes:P:POU2F1|POU2F1]]|2.66|0.04|
|[[:human_genes:C:C15orf41|C15orf41]]|2.70|0.01|
|[[:human_genes:A:ATP5C1|ATP5C1]]|2.71|0.01|
|[[:human_genes:I:ITPK1|ITPK1]]|2.80|<0.01|
|[[:human_genes:G:GLRX5|GLRX5]]|2.91|0.01|
|[[:human_genes:Z:ZBTB18|ZBTB18]]|2.92|<0.01|
|[[:human_genes:K:KMT2D|KMT2D]]|3.12|<0.01|
|[[:human_genes:P:PTEN|PTEN]]|3.13|<0.01|
|[[:human_genes:R:RBM26|RBM26]]|3.84|<0.01|
|[[:human_genes:C:CXorf56|CXorf56]]|4.39|<0.01|
|[[:human_genes:S:SPI1|SPI1]]|4.50|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.13|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.084|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.074|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp504|MK2206 4μM R08 exp504]]|0.071|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp275|Citral 75μM R06 exp275]]|0.07|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.062|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.053|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.053|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|0.053|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp433|LJH685 50μM R08 exp433]]|0.052|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.052|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.052|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.051|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.051|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.051|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|0.051|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.087|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.072|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.065|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.063|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.059|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.057|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|0.054|<button type="primary" size="small" modal="23">View</button>|
</modal>


<modal id="1" size="lg" title="Cannabidiol 20μM R08 exp466  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp466.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Cannabidiol 20μM R08 exp466  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp466_vs_exp90.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Cannabidiol 20μM R08 exp466  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp466_vs_exp492.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Cannabidiol 20μM R08 exp466  vs  MK2206 4μM R08 exp504">
{{:chemogenomics:comparison_plots:exp466_vs_exp504.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Citral 75μM R06 exp275">
{{:chemogenomics:comparison_plots:exp275_vs_exp466.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp466_vs_exp488.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp466.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Cannabidiol 20μM R08 exp466  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp466_vs_exp85.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Cannabidiol 20μM R08 exp466  vs  QNZ 0.01μM R08 exp439">
{{:chemogenomics:comparison_plots:exp439_vs_exp466.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Cannabidiol 20μM R08 exp466  vs  LJH685 50μM R08 exp433">
{{:chemogenomics:comparison_plots:exp433_vs_exp466.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp357_vs_exp466.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp466.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp416_vs_exp466.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Cannabidiol 20μM R08 exp466  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp466_vs_exp483.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp442_vs_exp466.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Cannabidiol 20μM R08 exp466  vs  ZLN024 50μM R08 exp538">
{{:chemogenomics:comparison_plots:exp466_vs_exp538.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp465_vs_exp466.png?nolink |}}
</modal>

<modal id="18" size="lg" title="BVD-523 15μM R02 exp67  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp466_vs_exp67.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp269_vs_exp466.png?nolink |}}
</modal>

<modal id="20" size="lg" title="CAY10603 0.55μM R08 exp467  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp466_vs_exp467.png?nolink |}}
</modal>

<modal id="21" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp466_vs_exp468.png?nolink |}}
</modal>

<modal id="22" size="lg" title="BS-181 20μM R08 exp461  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp461_vs_exp466.png?nolink |}}
</modal>

<modal id="23" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp334_vs_exp466.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|phosphatidylethanolamine biosynthetic process|204.56|SELENOI,PCYT2,CEPT1|
|CDP-alcohol phosphatidyltransferase activity|175.33|SELENOI,CEPT1|
|proton-transporting V-type ATPase, V0 domain|167.36|ATP6V0E1,ATP6V0B,ATP6V0A2|
|phosphotransferase activity, for other substituted phosphate groups|116.89|PTDSS2,SELENOI,DPAGT1,CEPT1|
|proton-transporting two-sector ATPase complex, proton-transporting domain|80.04|ATP6V0E1,ATP6V0B,ATP6V0A2|
|proton-transporting ATPase activity, rotational mechanism|80.04|ATP6V0E1,ATP6V0B,ATP6V0A2|
|ATPase-coupled ion transmembrane transporter activity|80.04|ATP6V0E1,ATP6V0B,ATP6V0A2|
|phosphatidylethanolamine metabolic process|70.81|SELENOI,PCYT2,CEPT1|
|proton-transporting V-type ATPase complex|68.19|ATP6V0E1,ATP6V0B,ATP6V0A2|
|vacuolar acidification|55.79|ATP6V0E1,ATP6V0B,ATP6V0A2|
|proton-transporting two-sector ATPase complex|40.91|ATP6V0E1,ATP6V0B,ATP6V0A2|
|regulation of macroautophagy|19.92|ATP6V0E1,ATP6V0B,ATP6V0A2,TSC1,BECN1|
|glycerolipid biosynthetic process|17.37|PTDSS2,SELENOI,PCYT2,CEPT1,LPGAT1,BECN1|
|glycerophospholipid biosynthetic process|15.90|PTDSS2,SELENOI,PCYT2,CEPT1,BECN1|
|phospholipid biosynthetic process|15.80|PTDSS2,SELENOI,PCYT2,CEPT1,LPGAT1,BECN1|
|glycerophospholipid metabolic process|13.44|PTDSS2,SELENOI,PCYT2,CEPT1,LPGAT1,BECN1|
|glycerolipid metabolic process|10.83|PTDSS2,SELENOI,PCYT2,CEPT1,LPGAT1,BECN1|
|phospholipid metabolic process|10.64|PTDSS2,SELENOI,PCYT2,CEPT1,LPGAT1,BECN1|
|regulation of autophagy|10.58|ATP6V0E1,ATP6V0B,ATP6V0A2,PRKAA1,TSC1,BECN1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>