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Ask your administrator if you think this is wrong. ====== Doxorubicin 0.02μM R08 exp478 ====== ==== Mechanism of Action ==== DNA intercalator, traps topoisomerase II complex * **<color #00a2e8>Class / Subclass 1:</color>** DNA Damage, Repair and Replication / Topoisomerase II Inhibitor * **<color #00a2e8>Class / Subclass 2:</color>** Infectious Disease / Antibiotic ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%Doxorubicin Hydrochloride%% * **<color #00a2e8>Synonyms:</color>** Hydroxydaunorubicin (hydrochloride) * **<color #00a2e8>CAS #:</color>** 25316-40-9 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/443939|443939]] * **<color #00a2e8>IUPAC:</color>** %%(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1 * **<color #00a2e8>INCHI Key:</color>** MWWSFMDVAYGXBV-RUELKSSGSA-N * **<color #00a2e8>Molecular Weight:</color>** 580 * **<color #00a2e8>Canonical SMILES:</color>** CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl * **<color #00a2e8>Isomeric SMILES:</color>** C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl * **<color #00a2e8>Molecular Formula:</color>** 2-His 266) {{:chemogenomics:structures:chem-0287.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** Med Chem Express * **<color #00a2e8>Catalog #:</color>** HY-15142 * **<color #00a2e8>Lot #:</color>** 33687 </panel> <panel title='Compound Characterization' collapsed='true'> * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C27H29NO11 544.18134; found 544.18415 </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** Doxorubicin * **<color #00a2e8>Min:</color>** 3.3117; **<color #00a2e8>Max:</color>** 99.6172 {{:chemogenomics:dose_response:dr_529.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |0.0068 | | IC20 |0.0126 | | IC30 |0.0190 | | IC40 |0.0266 | | IC50 |0.0362 | | IC60 |0.0492 | | IC70 |0.0688 | | IC80 |0.1036 | | IC90 |0.1916 | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 08 * **<color #00a2e8>Dose</color>**: 20nM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: 0.5 * **<color #00a2e8>Numbers of reads</color>**: 16631623 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |0/75|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Doxorubicin_0.02uM_Round-8_exp478.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='Doxorubicin 0.02μM R08 exp478'> {{:chemogenomics:cranks_plots:exp478.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:C:COPB2|COPB2]]|-3.37|0.12| |[[:human_genes:C:CDK1|CDK1]]|-3.13|0.08| |[[:human_genes:C:CDC20|CDC20]]|-2.70|0.20| |[[:human_genes:N:NHEJ1|NHEJ1]]|-2.64|0.08| |[[:human_genes:L:LIG4|LIG4]]|-2.61|0.13| |[[:human_genes:C:CCNA2|CCNA2]]|-2.55|0.19| |[[:human_genes:P:PSMD14|PSMD14]]|-2.54|0.43| |[[:human_genes:C:CHMP2A|CHMP2A]]|-2.52|0.30| |[[:human_genes:T:TSC1|TSC1]]|-2.49|0.15| |[[:human_genes:R:RPL38|RPL38]]|-2.49|0.20| |[[:human_genes:S:SMG7|SMG7]]|-2.47|0.15| |[[:human_genes:E:ESPL1|ESPL1]]|-2.43|0.39| |[[:human_genes:T:TMEM30A|TMEM30A]]|-2.35|0.15| |[[:human_genes:R:RFC1|RFC1]]|-2.35|0.43| |[[:human_genes:A:AKAP12|AKAP12]]|-2.34|0.20| |[[:human_genes:C:COPB1|COPB1]]|-2.29|0.43| |[[:human_genes:P:PAN2|PAN2]]|-2.28|0.18| |[[:human_genes:U:UBA1|UBA1]]|-2.27|0.52| |[[:human_genes:N:NAPA|NAPA]]|-2.21|0.48| |[[:human_genes:T:TBCC|TBCC]]|-2.19|0.54| |[[:human_genes:R:RPL34|RPL34]]|-2.16|0.50| |[[:human_genes:P:PSMA1|PSMA1]]|-2.15|0.43| |[[:human_genes:T:TSC2|TSC2]]|-2.15|0.23| |[[:human_genes:C:C15orf52|C15orf52]]|-2.14|0.23| |[[:human_genes:T:TNPO3|TNPO3]]|-2.12|0.51| |[[:human_genes:P:PPP1R7|PPP1R7]]|-2.10|0.28| |[[:human_genes:K:KPNB1|KPNB1]]|-2.08|0.52| |[[:human_genes:Z:ZFYVE16|ZFYVE16]]|-2.07|0.43| |[[:human_genes:D:DNMT3A|DNMT3A]]|-2.05|0.33| |[[:human_genes:H:HIST1H1B|HIST1H1B]]|-2.03|0.34| |[[:human_genes:D:DOHH|DOHH]]|2.86|<0.01| |[[:human_genes:R:ROMO1|ROMO1]]|2.89|<0.01| |[[:human_genes:W:WDR24|WDR24]]|2.91|<0.01| |[[:human_genes:H:HYPK|HYPK]]|2.99|<0.01| |[[:human_genes:F:FBXO11|FBXO11]]|3.02|0.00| |[[:human_genes:A:ATP5A1|ATP5A1]]|3.06|<0.01| |[[:human_genes:A:ATP5B|ATP5B]]|3.08|0.00| |[[:human_genes:F:FAF2|FAF2]]|3.08|<0.01| |[[:human_genes:G:GFPT1|GFPT1]]|3.10|<0.01| |[[:human_genes:N:NSD1|NSD1]]|3.11|<0.01| |[[:human_genes:H:HSPA4|HSPA4]]|3.14|0.00| |[[:human_genes:E:EIF3F|EIF3F]]|3.15|0.00| |[[:human_genes:U:USO1|USO1]]|3.15|0.00| |[[:human_genes:U:UBQLN1|UBQLN1]]|3.35|0.00| |[[:human_genes:C:CYCS|CYCS]]|3.41|0.00| |[[:human_genes:Y:YWHAE|YWHAE]]|3.59|0.00| |[[:human_genes:H:HCCS|HCCS]]|3.72|0.00| |[[:human_genes:C:COPS7B|COPS7B]]|3.76|0.00| |[[:human_genes:R:RPTOR|RPTOR]]|3.84|0.00| |[[:human_genes:T:TP53|TP53]]|4.07|0.00| |[[:human_genes:A:APAF1|APAF1]]|4.19|0.00| |[[:human_genes:P:PKMYT1|PKMYT1]]|4.28|0.00| |[[:human_genes:E:EIF4A1|EIF4A1]]|4.33|0.00| |[[:human_genes:M:MARCH5|MARCH5]]|4.57|0.00| |[[:human_genes:P:PLAA|PLAA]]|4.73|0.00| |[[:human_genes:C:CASP9|CASP9]]|4.85|0.00| |[[:human_genes:N:NAA15|NAA15]]|5.57|0.00| |[[:human_genes:B:BAK1|BAK1]]|5.93|0.00| |[[:human_genes:T:TOP2A|TOP2A]]|6.09|0.00| |[[:human_genes:T:TOP2B|TOP2B]]|7.74|0.00| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.198|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.146|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp135|MS023 7μM R03 exp135]]|0.138|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.127|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp443|SNS-032 15μM R08 exp443]]|0.109|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp240|Pyridostatin 4μM R05 exp240]]|0.108|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.107|<button type="primary" size="small" modal="7">View</button>| |[[:results:exp515|PU-H71 1μM R08 exp515]]|0.106|<button type="primary" size="small" modal="8">View</button>| |[[:results:exp34|Rotenone 20μM R00 exp34]]|0.098|<button type="primary" size="small" modal="9">View</button>| |[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.093|<button type="primary" size="small" modal="10">View</button>| |[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.092|<button type="primary" size="small" modal="11">View</button>| |[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.09|<button type="primary" size="small" modal="12">View</button>| |[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.09|<button type="primary" size="small" modal="13">View</button>| |[[:results:exp19|Etoposide 1μM R00 exp19]]|0.087|<button type="primary" size="small" modal="14">View</button>| |[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.081|<button type="primary" size="small" modal="15">View</button>| |[[:results:exp198|Etoposide 0.1μM R05 exp198]]|0.077|<button type="primary" size="small" modal="16">View</button>| |[[:results:exp512|Olaparib 4μM R08 exp512]]|0.076|<button type="primary" size="small" modal="17">View</button>| |[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.074|<button type="primary" size="small" modal="18">View</button>| |[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.072|<button type="primary" size="small" modal="19">View</button>| |[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.069|<button type="primary" size="small" modal="20">View</button>| |[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.063|<button type="primary" size="small" modal="21">View</button>| |[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.062|<button type="primary" size="small" modal="22">View</button>| |[[:results:exp485|GSK626616 14μM R08 exp485]]|0.062|<button type="primary" size="small" modal="23">View</button>| |[[:results:exp134|MS023 2μM R03 exp134]]|0.06|<button type="primary" size="small" modal="24">View</button>| |[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.059|<button type="primary" size="small" modal="25">View</button>| |[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.057|<button type="primary" size="small" modal="26">View</button>| |[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.055|<button type="primary" size="small" modal="27">View</button>| |[[:results:exp360|Genistein 15μM R07 exp360]]|0.054|<button type="primary" size="small" modal="28">View</button>| |[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.053|<button type="primary" size="small" modal="29">View</button>| |[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|0.052|<button type="primary" size="small" modal="30">View</button>| |[[:results:exp502|Milciclib 2μM R08 exp502]]|0.051|<button type="primary" size="small" modal="31">View</button>| |[[:results:exp532|TIC10 10μM R08 exp532]]|0.051|<button type="primary" size="small" modal="32">View</button>| |[[:results:exp85|UM0129480 7μM R02 exp85]]|0.051|<button type="primary" size="small" modal="33">View</button>| |[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.152|<button type="primary" size="small" modal="34">View</button>| |[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.13|<button type="primary" size="small" modal="35">View</button>| |[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.124|<button type="primary" size="small" modal="36">View</button>| |[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.122|<button type="primary" size="small" modal="37">View</button>| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.121|<button type="primary" size="small" modal="38">View</button>| |[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.109|<button type="primary" size="small" modal="39">View</button>| |[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.103|<button type="primary" size="small" modal="40">View</button>| |[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.096|<button type="primary" size="small" modal="41">View</button>| |[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.093|<button type="primary" size="small" modal="42">View</button>| |[[:results:exp211|AICAR 240μM R05 exp211]]|0.087|<button type="primary" size="small" modal="43">View</button>| |[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.084|<button type="primary" size="small" modal="44">View</button>| |[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.084|<button type="primary" size="small" modal="45">View</button>| |[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.083|<button type="primary" size="small" modal="46">View</button>| |[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.081|<button type="primary" size="small" modal="47">View</button>| |[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.075|<button type="primary" size="small" modal="48">View</button>| |[[:results:exp539|42°C R08 exp539]]|0.073|<button type="primary" size="small" modal="49">View</button>| |[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.067|<button type="primary" size="small" modal="50">View</button>| |[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.064|<button type="primary" size="small" modal="51">View</button>| |[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.06|<button type="primary" size="small" modal="52">View</button>| |[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.058|<button type="primary" size="small" modal="53">View</button>| |[[:results:exp116|AICAR 240μM R03 exp116]]|0.054|<button type="primary" size="small" modal="54">View</button>| |[[:results:exp93|DABN racemic mixture R03 exp93]]|0.054|<button type="primary" size="small" modal="55">View</button>| |[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.053|<button type="primary" size="small" modal="56">View</button>| |[[:results:exp17|DABN 20μM R00 exp17]]|0.051|<button type="primary" size="small" modal="57">View</button>| </modal> <modal id="1" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Etoposide 0.3μM R05 exp199"> {{:chemogenomics:comparison_plots:exp199_vs_exp478.png?nolink |}} </modal> <modal id="2" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs THZ1 0.06μM R08 exp531"> {{:chemogenomics:comparison_plots:exp478_vs_exp531.png?nolink |}} </modal> <modal id="3" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs MS023 7μM R03 exp135"> {{:chemogenomics:comparison_plots:exp135_vs_exp478.png?nolink |}} </modal> <modal id="4" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Mitomycin-C 0.06μM R08 exp503"> {{:chemogenomics:comparison_plots:exp478_vs_exp503.png?nolink |}} </modal> <modal id="5" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs SNS-032 15μM R08 exp443"> {{:chemogenomics:comparison_plots:exp443_vs_exp478.png?nolink |}} </modal> <modal id="6" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Pyridostatin 4μM R05 exp240"> {{:chemogenomics:comparison_plots:exp240_vs_exp478.png?nolink |}} </modal> <modal id="7" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs RO-3307 4.7μM R02 exp80"> {{:chemogenomics:comparison_plots:exp478_vs_exp80.png?nolink |}} </modal> <modal id="8" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs PU-H71 1μM R08 exp515"> {{:chemogenomics:comparison_plots:exp478_vs_exp515.png?nolink |}} </modal> <modal id="9" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Rotenone 20μM R00 exp34"> {{:chemogenomics:comparison_plots:exp34_vs_exp478.png?nolink |}} </modal> <modal id="10" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Staurosporine 0.02μM R08 exp524"> {{:chemogenomics:comparison_plots:exp478_vs_exp524.png?nolink |}} </modal> <modal id="11" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Pimelic-diphenylamide-106 5μM R00 exp28"> {{:chemogenomics:comparison_plots:exp28_vs_exp478.png?nolink |}} </modal> <modal id="12" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs UM131593 0.2μM R03 exp106"> {{:chemogenomics:comparison_plots:exp106_vs_exp478.png?nolink |}} </modal> <modal id="13" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp478_vs_exp488.png?nolink |}} </modal> <modal id="14" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Etoposide 1μM R00 exp19"> {{:chemogenomics:comparison_plots:exp19_vs_exp478.png?nolink |}} </modal> <modal id="15" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Hippuristanol 0.12μM R08 exp489 no dilution day6"> {{:chemogenomics:comparison_plots:exp478_vs_exp489.png?nolink |}} </modal> <modal id="16" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Etoposide 0.1μM R05 exp198"> {{:chemogenomics:comparison_plots:exp198_vs_exp478.png?nolink |}} </modal> <modal id="17" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Olaparib 4μM R08 exp512"> {{:chemogenomics:comparison_plots:exp478_vs_exp512.png?nolink |}} </modal> <modal id="18" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs MLN-4924 2μM R00 exp22"> {{:chemogenomics:comparison_plots:exp22_vs_exp478.png?nolink |}} </modal> <modal id="19" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs JQ1 0.8μM R08 exp435"> {{:chemogenomics:comparison_plots:exp435_vs_exp478.png?nolink |}} </modal> <modal id="20" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Tanespimycin 14μM R08 exp527"> {{:chemogenomics:comparison_plots:exp478_vs_exp527.png?nolink |}} </modal> <modal id="21" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Thimerosal 0.85μM R08 exp529"> {{:chemogenomics:comparison_plots:exp478_vs_exp529.png?nolink |}} </modal> <modal id="22" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs GSK461364A 0.1μM R03 exp126"> {{:chemogenomics:comparison_plots:exp126_vs_exp478.png?nolink |}} </modal> <modal id="23" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs GSK626616 14μM R08 exp485"> {{:chemogenomics:comparison_plots:exp478_vs_exp485.png?nolink |}} </modal> <modal id="24" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs MS023 2μM R03 exp134"> {{:chemogenomics:comparison_plots:exp134_vs_exp478.png?nolink |}} </modal> <modal id="25" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Latrunculin-B 10μM R07 exp374"> {{:chemogenomics:comparison_plots:exp374_vs_exp478.png?nolink |}} </modal> <modal id="26" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs GSK-J4 1.5μM R08 exp441"> {{:chemogenomics:comparison_plots:exp441_vs_exp478.png?nolink |}} </modal> <modal id="27" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs LLY-283 2.6μM R06 exp290"> {{:chemogenomics:comparison_plots:exp290_vs_exp478.png?nolink |}} </modal> <modal id="28" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Genistein 15μM R07 exp360"> {{:chemogenomics:comparison_plots:exp360_vs_exp478.png?nolink |}} </modal> <modal id="29" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Vinblastine 0.2μM R03 exp108"> {{:chemogenomics:comparison_plots:exp108_vs_exp478.png?nolink |}} </modal> <modal id="30" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Tozasertib 0.1μM R07 exp414"> {{:chemogenomics:comparison_plots:exp414_vs_exp478.png?nolink |}} </modal> <modal id="31" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Milciclib 2μM R08 exp502"> {{:chemogenomics:comparison_plots:exp478_vs_exp502.png?nolink |}} </modal> <modal id="32" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs TIC10 10μM R08 exp532"> {{:chemogenomics:comparison_plots:exp478_vs_exp532.png?nolink |}} </modal> <modal id="33" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs UM0129480 7μM R02 exp85"> {{:chemogenomics:comparison_plots:exp478_vs_exp85.png?nolink |}} </modal> <modal id="34" size="lg" title="Bleomycin 5μM R08 exp459 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp459_vs_exp478.png?nolink |}} </modal> <modal id="35" size="lg" title="CI-1040 9.5μM R08 exp472 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp472_vs_exp478.png?nolink |}} </modal> <modal id="36" size="lg" title="Actinomycin-D 0.001μM R00 exp3 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp3_vs_exp478.png?nolink |}} </modal> <modal id="37" size="lg" title="Benzoate 20000μM R08 exp456 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp456_vs_exp478.png?nolink |}} </modal> <modal id="38" size="lg" title="5-Fluorouracil 20μM R00 exp2 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp2_vs_exp478.png?nolink |}} </modal> <modal id="39" size="lg" title="Aphidicolin 0.4μM R08 exp440 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp440_vs_exp478.png?nolink |}} </modal> <modal id="40" size="lg" title="Atovaquone 15μM R08 exp451 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp451_vs_exp478.png?nolink |}} </modal> <modal id="41" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp259_vs_exp478.png?nolink |}} </modal> <modal id="42" size="lg" title="CR131-b 0.005μM R08 exp474 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp474_vs_exp478.png?nolink |}} </modal> <modal id="43" size="lg" title="AICAR 240μM R05 exp211 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp211_vs_exp478.png?nolink |}} </modal> <modal id="44" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp357_vs_exp478.png?nolink |}} </modal> <modal id="45" size="lg" title="CB-5083 0.4μM R08 exp468 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp468_vs_exp478.png?nolink |}} </modal> <modal id="46" size="lg" title="Artemisinin 50μM R08 exp450 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp450_vs_exp478.png?nolink |}} </modal> <modal id="47" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp448_vs_exp478.png?nolink |}} </modal> <modal id="48" size="lg" title="BI-2536 0.02μM R03 exp96 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp478_vs_exp96.png?nolink |}} </modal> <modal id="49" size="lg" title="42°C R08 exp539 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp478_vs_exp539.png?nolink |}} </modal> <modal id="50" size="lg" title="Deferoxamine 11μM R07 exp350 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp350_vs_exp478.png?nolink |}} </modal> <modal id="51" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp445_vs_exp478.png?nolink |}} </modal> <modal id="52" size="lg" title="Dinaciclib 0.007μM R07 exp355 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp355_vs_exp478.png?nolink |}} </modal> <modal id="53" size="lg" title="BI-6727 0.04μM R03 exp98 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp478_vs_exp98.png?nolink |}} </modal> <modal id="54" size="lg" title="AICAR 240μM R03 exp116 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp116_vs_exp478.png?nolink |}} </modal> <modal id="55" size="lg" title="DABN racemic mixture R03 exp93 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp478_vs_exp93.png?nolink |}} </modal> <modal id="56" size="lg" title="Centrinone 0.5μM R07 exp343 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp343_vs_exp478.png?nolink |}} </modal> <modal id="57" size="lg" title="DABN 20μM R00 exp17 vs Doxorubicin 0.02μM R08 exp478"> {{:chemogenomics:comparison_plots:exp17_vs_exp478.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms"> ^GO Term^Fold Change^Genes^ |DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity|552.30|TOP2B,TOP2A| |apoptosome|552.30|CASP9,APAF1| |angiostatin binding|368.20|ATP5F1B,ATP5F1A| |activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|331.38|CASP9,APAF1,CYCS| |mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)|276.15|ATP5F1B,ATP5F1A| |intrinsic apoptotic signaling pathway|17.26|BAK1,CASP9,APAF1,TP53,CYCS| </modal> Last modified: 2026/01/15 21:36by 127.0.0.1