Fas-L 44ng/ml R08 exp482 [The Human Chemical-Genetic Interaction Map Project]

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====== Fas-L 44ng/ml R08 exp482 ======
==== Mechanism of Action ====
Ligand for Fas receptor, triggers apoptosis
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Other Receptor Agonist




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 17.9kDa
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** HHHHHHHHPS PPPEKKELRK VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE
{{:chemogenomics:structures:chem-0291.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** PeproTech
    * **<color #00a2e8>Catalog #:</color>** 310-03H
    * **<color #00a2e8>Lot #:</color>** 0217496 B1717
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Fas_L
    * **<color #00a2e8>Min:</color>** -13.1002; **<color #00a2e8>Max:</color>** 11.4956
{{:chemogenomics:dose_response:dr_537.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 44ng/mL
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.9
    * **<color #00a2e8>Numbers of reads</color>**: 16827520


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Fas-L_44_ng_per_mL_Round-8_exp482.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Fas-L 44ng/ml R08 exp482'>
{{:chemogenomics:cranks_plots:exp482.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:Q:QSER1|QSER1]]|-2.85|0.05|
|[[:human_genes:G:GARS|GARS]]|-2.83|0.76|
|[[:human_genes:D:DARS2|DARS2]]|-2.75|0.55|
|[[:human_genes:I:ISLR|ISLR]]|-2.29|0.52|
|[[:human_genes:A:ADSL|ADSL]]|-2.25|0.76|
|[[:human_genes:S:SPCS1|SPCS1]]|-2.20|0.55|
|[[:human_genes:A:ADAMTS3|ADAMTS3]]|-2.18|0.52|
|[[:human_genes:G:GPR173|GPR173]]|-2.16|0.52|
|[[:human_genes:T:TTC4|TTC4]]|-2.16|0.52|
|[[:human_genes:O:OR8G5|OR8G5]]|-2.14|0.52|
|[[:human_genes:R:RSRC2|RSRC2]]|-2.11|0.81|
|[[:human_genes:S:SNAPC5|SNAPC5]]|-2.09|0.76|
|[[:human_genes:N:NR2F1|NR2F1]]|-2.06|0.55|
|[[:human_genes:T:TRIAP1|TRIAP1]]|-2.06|0.76|
|[[:human_genes:R:RBM42|RBM42]]|-1.94|0.76|
|[[:human_genes:D:DCUN1D2|DCUN1D2]]|-1.93|0.76|
|[[:human_genes:L:LOC643802|LOC643802]]|-1.90|0.77|
|[[:human_genes:C:CADPS|CADPS]]|-1.89|0.76|
|[[:human_genes:K:KIAA1958|KIAA1958]]|-1.89|0.76|
|[[:human_genes:H:HNRNPH3|HNRNPH3]]|-1.88|0.76|
|[[:human_genes:L:LRRC14B|LRRC14B]]|-1.87|0.76|
|[[:human_genes:T:TEX10|TEX10]]|-1.87|0.76|
|[[:human_genes:A:ATIC|ATIC]]|-1.86|0.76|
|[[:human_genes:O:OR10K2|OR10K2]]|-1.86|0.76|
|[[:human_genes:C:CRISPLD1|CRISPLD1]]|-1.84|0.76|
|[[:human_genes:F:FAM207A|FAM207A]]|-1.83|0.76|
|[[:human_genes:T:TSPAN32|TSPAN32]]|-1.83|0.76|
|[[:human_genes:S:SMC1A|SMC1A]]|-1.82|0.81|
|[[:human_genes:P:PDE6G|PDE6G]]|-1.82|0.76|
|[[:human_genes:P:PARK7|PARK7]]|-1.81|0.76|
|[[:human_genes:T:TSGA13|TSGA13]]|1.92|0.60|
|[[:human_genes:K:KRTAP10-3|KRTAP10-3]]|1.92|0.60|
|[[:human_genes:A:ABCA6|ABCA6]]|1.93|0.60|
|[[:human_genes:C:CD79A|CD79A]]|1.95|0.60|
|[[:human_genes:P:PSMD14|PSMD14]]|1.96|0.84|
|[[:human_genes:D:DNAJC7|DNAJC7]]|1.97|0.54|
|[[:human_genes:L:LAYN|LAYN]]|1.97|0.54|
|[[:human_genes:P:PCNXL3|PCNXL3]]|1.99|0.60|
|[[:human_genes:S:SHFM1|SHFM1]]|2.00|0.80|
|[[:human_genes:E:ETF1|ETF1]]|2.03|0.60|
|[[:human_genes:M:MKL2|MKL2]]|2.03|0.54|
|[[:human_genes:P:PSEN2|PSEN2]]|2.09|0.54|
|[[:human_genes:Z:ZNF254|ZNF254]]|2.09|0.50|
|[[:human_genes:M:MIR205HG|MIR205HG]]|2.11|0.85|
|[[:human_genes:P:PSMD3|PSMD3]]|2.12|0.84|
|[[:human_genes:G:GTPBP4|GTPBP4]]|2.13|0.63|
|[[:human_genes:I:IL1RL2|IL1RL2]]|2.14|0.54|
|[[:human_genes:T:TAF10|TAF10]]|2.19|0.50|
|[[:human_genes:K:KANSL2|KANSL2]]|2.20|0.50|
|[[:human_genes:P:PRR14|PRR14]]|2.21|0.50|
|[[:human_genes:D:DNAJA1|DNAJA1]]|2.22|0.50|
|[[:human_genes:C:CLLU1|CLLU1]]|2.23|0.54|
|[[:human_genes:N:NXNL1|NXNL1]]|2.26|0.50|
|[[:human_genes:P:POLD2|POLD2]]|2.28|0.60|
|[[:human_genes:Z:ZIM2|ZIM2]]|2.31|0.50|
|[[:human_genes:N:NUDT18|NUDT18]]|2.34|0.60|
|[[:human_genes:T:TRAPPC8|TRAPPC8]]|2.48|0.54|
|[[:human_genes:N:NUP133|NUP133]]|2.55|0.30|
|[[:human_genes:C:CSNK1A1|CSNK1A1]]|2.74|0.32|
|[[:human_genes:X:XAB2|XAB2]]|3.18|0.60|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>