Heregulin-B 44ng/ml R08 exp486 [The Human Chemical-Genetic Interaction Map Project]

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====== Heregulin-B 44ng/ml R08 exp486 ======
==== Mechanism of Action ====
EGF family ligand for ErbB receptors, a.k.a. neuregulin-1
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Receptor Ligand




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 7.5kDa
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM
{{:chemogenomics:structures:chem-0295.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Cusabio
    * **<color #00a2e8>Catalog #:</color>** CSB-AP002851HU
    * **<color #00a2e8>Lot #:</color>** 03962
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Heregulin_B
    * **<color #00a2e8>Min:</color>** -17.4229; **<color #00a2e8>Max:</color>** 8.7022
{{:chemogenomics:dose_response:dr_542.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 44ng/mL
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.2
    * **<color #00a2e8>Numbers of reads</color>**: 16605477


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Heregulin-B_44_ng_per_mL_Round-8_exp486.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Heregulin-B 44ng/ml R08 exp486'>
{{:chemogenomics:cranks_plots:exp486.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:R:RABGGTB|RABGGTB]]|-2.48|0.49|
|[[:human_genes:P:POLR3B|POLR3B]]|-2.34|0.49|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.26|0.66|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.21|0.66|
|[[:human_genes:A:ATIC|ATIC]]|-2.15|0.66|
|[[:human_genes:E:EXOC2|EXOC2]]|-2.14|0.67|
|[[:human_genes:N:N6AMT1|N6AMT1]]|-2.12|0.79|
|[[:human_genes:F:FAF2|FAF2]]|-2.08|0.78|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.08|0.79|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.07|0.67|
|[[:human_genes:T:TMEM251|TMEM251]]|-2.05|0.70|
|[[:human_genes:A:ASB3|ASB3]]|-2.05|0.70|
|[[:human_genes:C:CARD8|CARD8]]|-2.03|0.67|
|[[:human_genes:N:NAA15|NAA15]]|-2.02|0.73|
|[[:human_genes:R:RMND5A|RMND5A]]|-2.00|0.67|
|[[:human_genes:R:RPL18|RPL18]]|-2.00|0.94|
|[[:human_genes:T:TMC2|TMC2]]|-2.00|0.73|
|[[:human_genes:Z:ZGRF1|ZGRF1]]|-1.99|0.67|
|[[:human_genes:R:RAPGEF6|RAPGEF6]]|-1.99|0.67|
|[[:human_genes:F:FNTA|FNTA]]|-1.94|0.70|
|[[:human_genes:R:RBMX2|RBMX2]]|-1.91|0.79|
|[[:human_genes:A:ASAP3|ASAP3]]|-1.89|0.73|
|[[:human_genes:C:COG2|COG2]]|-1.89|0.81|
|[[:human_genes:S:SSR2|SSR2]]|-1.88|0.73|
|[[:human_genes:S:ST6GAL2|ST6GAL2]]|-1.88|0.81|
|[[:human_genes:L:LAYN|LAYN]]|-1.84|0.78|
|[[:human_genes:L:LY6G5C|LY6G5C]]|-1.84|0.79|
|[[:human_genes:B:BUD13|BUD13]]|-1.84|0.79|
|[[:human_genes:Z:ZNF304|ZNF304]]|-1.84|0.78|
|[[:human_genes:N:NDUFB9|NDUFB9]]|-1.84|0.79|
|[[:human_genes:L:LDLRAD2|LDLRAD2]]|1.87|0.69|
|[[:human_genes:H:HDAC11|HDAC11]]|1.88|0.82|
|[[:human_genes:K:KCNAB3|KCNAB3]]|1.89|0.69|
|[[:human_genes:D:DDX27|DDX27]]|1.89|0.82|
|[[:human_genes:O:OSBP|OSBP]]|1.91|0.77|
|[[:human_genes:S:SEC24B|SEC24B]]|1.91|0.69|
|[[:human_genes:P:PLGLB1|PLGLB1]]|1.92|0.69|
|[[:human_genes:L:LIN9|LIN9]]|1.92|0.77|
|[[:human_genes:G:GABRR1|GABRR1]]|1.92|0.69|
|[[:human_genes:T:TSHZ3|TSHZ3]]|1.92|0.77|
|[[:human_genes:P:PLGLB2|PLGLB2]]|1.92|0.69|
|[[:human_genes:A:ACADM|ACADM]]|1.93|0.69|
|[[:human_genes:C:CD302|CD302]]|1.95|0.74|
|[[:human_genes:S:SLC37A4|SLC37A4]]|1.95|0.82|
|[[:human_genes:H:HSPH1|HSPH1]]|1.98|0.69|
|[[:human_genes:Z:ZSWIM8|ZSWIM8]]|1.98|0.69|
|[[:human_genes:M:MXD1|MXD1]]|2.00|0.69|
|[[:human_genes:A:ARHGEF38|ARHGEF38]]|2.02|0.69|
|[[:human_genes:N:N6AMT2|N6AMT2]]|2.05|0.69|
|[[:human_genes:N:NUP98|NUP98]]|2.10|0.68|
|[[:human_genes:N:NOTCH2NL|NOTCH2NL]]|2.19|0.69|
|[[:human_genes:U:USP27X|USP27X]]|2.22|0.84|
|[[:human_genes:G:GNL2|GNL2]]|2.23|0.62|
|[[:human_genes:E:ELMO1|ELMO1]]|2.25|0.62|
|[[:human_genes:M:MORN2|MORN2]]|2.26|0.82|
|[[:human_genes:A:ADAR|ADAR]]|2.28|0.62|
|[[:human_genes:T:TRIM44|TRIM44]]|2.32|0.62|
|[[:human_genes:M:MAL|MAL]]|2.42|0.62|
|[[:human_genes:R:RPL12|RPL12]]|2.48|0.69|
|[[:human_genes:R:RFC2|RFC2]]|2.92|0.69|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp293|Myriocin 25μM R06 exp293]]|0.065|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|0.058|<button type="primary" size="small" modal="2">View</button>|
</modal>


<modal id="1" size="lg" title="Heregulin-B 44ng/ml R08 exp486  vs  Myriocin 25μM R06 exp293">
{{:chemogenomics:comparison_plots:exp293_vs_exp486.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Heregulin-B 44ng/ml R08 exp486  vs  VHL-ligand-1 20μM R07 exp421">
{{:chemogenomics:comparison_plots:exp421_vs_exp486.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>