Show pageOld revisionsBacklinksFold/unfold allBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Hinokiflavone 12μM R08 exp487 ====== ==== Mechanism of Action ==== Putative splicing inhibitor, ROS generation * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Natural Product * **<color #00a2e8>Class / Subclass 2:</color>** Gene Regulation / Splicing Inhibitor ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%Hinokiflavone%% * **<color #00a2e8>Synonyms:</color>** N/A * **<color #00a2e8>CAS #:</color>** 19202-36-9 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5281627|5281627]] * **<color #00a2e8>IUPAC:</color>** %%6-[4-(5,7-dihydroxy-4-oxochromen-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C30H18O10/c31-16-5-1-14(2-6-16)24-12-21(35)28-26(40-24)13-22(36)30(29(28)37)38-18-7-3-15(4-8-18)23-11-20(34)27-19(33)9-17(32)10-25(27)39-23/h1-13,31-33,36-37H * **<color #00a2e8>INCHI Key:</color>** WTDHMFBJQJSTMH-UHFFFAOYSA-N * **<color #00a2e8>Molecular Weight:</color>** 538.5 * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC4=CC=C(C=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O * **<color #00a2e8>Isomeric SMILES:</color>** N/A * **<color #00a2e8>Molecular Formula:</color>** ASFYKHLGIE FMEAE {{:chemogenomics:structures:chem-0296.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** ExtraSynthese * **<color #00a2e8>Catalog #:</color>** 1017 * **<color #00a2e8>Lot #:</color>** 06-0909/0 </panel> <panel title='Compound Characterization' collapsed='true'> * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C30H18O10 539.09727; found 539.09919 </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** Hinokiflavone * **<color #00a2e8>Min:</color>** -8.2062; **<color #00a2e8>Max:</color>** 89.3086 {{:chemogenomics:dose_response:dr_613.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |2.4780 | | IC20 |4.4790 | | IC30 |6.6380 | | IC40 |9.1650 | | IC50 |12.3200 | | IC60 |16.5700 | | IC70 |22.8800 | | IC80 |33.9100 | | IC90 |61.2900 | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 08 * **<color #00a2e8>Dose</color>**: 12µM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: -0.2 * **<color #00a2e8>Numbers of reads</color>**: 18147570 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |0/7|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Hinokiflavone_12uM_Round-8_exp487.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='Hinokiflavone 12μM R08 exp487'> {{:chemogenomics:cranks_plots:exp487.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:A:AURKB|AURKB]]|-2.84|0.36| |[[:human_genes:S:SF3A1|SF3A1]]|-2.78|0.28| |[[:human_genes:S:SAP130|SAP130]]|-2.74|0.14| |[[:human_genes:M:MYH2|MYH2]]|-2.74|0.14| |[[:human_genes:F:FIS1|FIS1]]|-2.47|0.15| |[[:human_genes:V:VPS54|VPS54]]|-2.38|0.28| |[[:human_genes:S:SEC23A|SEC23A]]|-2.38|0.21| |[[:human_genes:E:ESPL1|ESPL1]]|-2.38|0.36| |[[:human_genes:S:SEC13|SEC13]]|-2.37|0.42| |[[:human_genes:C:CDCA8|CDCA8]]|-2.32|0.42| |[[:human_genes:A:AHCTF1|AHCTF1]]|-2.27|0.28| |[[:human_genes:P:PSMC2|PSMC2]]|-2.26|0.39| |[[:human_genes:U:UBAP1|UBAP1]]|-2.25|0.28| |[[:human_genes:C:CACNA1F|CACNA1F]]|-2.24|0.36| |[[:human_genes:I:INTS1|INTS1]]|-2.21|0.41| |[[:human_genes:M:MAMLD1|MAMLD1]]|-2.21|0.33| |[[:human_genes:G:GLE1|GLE1]]|-2.19|0.48| |[[:human_genes:M:MPHOSPH10|MPHOSPH10]]|-2.19|0.42| |[[:human_genes:P:PSMD3|PSMD3]]|-2.19|0.52| |[[:human_genes:T:TCEB3CL2|TCEB3CL2]]|-2.16|0.28| |[[:human_genes:P:PSMC3|PSMC3]]|-2.15|0.61| |[[:human_genes:T:TSPY1|TSPY1]]|-2.15|0.28| |[[:human_genes:C:C17orf50|C17orf50]]|-2.14|0.39| |[[:human_genes:P:PRPF8|PRPF8]]|-2.14|0.54| |[[:human_genes:G:GRB7|GRB7]]|-2.13|0.28| |[[:human_genes:P:PCDHGB6|PCDHGB6]]|-2.13|0.28| |[[:human_genes:M:MRS2|MRS2]]|-2.12|0.28| |[[:human_genes:I:INO80E|INO80E]]|-2.11|0.36| |[[:human_genes:W:WDR61|WDR61]]|-2.10|0.36| |[[:human_genes:V:VPS52|VPS52]]|-2.09|0.49| |[[:human_genes:C:CEPT1|CEPT1]]|2.22|0.08| |[[:human_genes:S:SRP14|SRP14]]|2.25|0.07| |[[:human_genes:G:GTF3C6|GTF3C6]]|2.25|0.12| |[[:human_genes:K:KHDRBS1|KHDRBS1]]|2.26|0.07| |[[:human_genes:C:C11orf57|C11orf57]]|2.26|0.07| |[[:human_genes:C:C1QTNF3|C1QTNF3]]|2.27|0.07| |[[:human_genes:N:N6AMT1|N6AMT1]]|2.32|0.21| |[[:human_genes:K:KRAS|KRAS]]|2.32|0.15| |[[:human_genes:P:PTDSS1|PTDSS1]]|2.36|0.05| |[[:human_genes:C:CBFB|CBFB]]|2.36|0.05| |[[:human_genes:X:XPO5|XPO5]]|2.36|0.13| |[[:human_genes:C:C17orf89|C17orf89]]|2.36|0.05| |[[:human_genes:T:TAF5L|TAF5L]]|2.37|0.07| |[[:human_genes:M:MED6|MED6]]|2.37|0.05| |[[:human_genes:C:C10orf12|C10orf12]]|2.38|0.07| |[[:human_genes:M:MTRNR2L4|MTRNR2L4]]|2.40|0.41| |[[:human_genes:E:EPB41L2|EPB41L2]]|2.42|0.05| |[[:human_genes:N:NDUFAF4|NDUFAF4]]|2.43|0.05| |[[:human_genes:M:MIER2|MIER2]]|2.45|0.06| |[[:human_genes:A:AASDHPPT|AASDHPPT]]|2.45|0.05| |[[:human_genes:M:MRPS6|MRPS6]]|2.46|0.06| |[[:human_genes:A:ATIC|ATIC]]|2.54|0.04| |[[:human_genes:D:DPAGT1|DPAGT1]]|2.57|0.05| |[[:human_genes:T:TRMT10A|TRMT10A]]|2.58|0.04| |[[:human_genes:C:CEP44|CEP44]]|2.62|0.04| |[[:human_genes:T:THG1L|THG1L]]|2.73|0.02| |[[:human_genes:M:MED16|MED16]]|2.80|0.05| |[[:human_genes:C:CCDC101|CCDC101]]|2.83|0.01| |[[:human_genes:L:LAMTOR4|LAMTOR4]]|2.91|0.01| |[[:human_genes:V:VEZT|VEZT]]|2.98|0.01| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp515|PU-H71 1μM R08 exp515]]|0.076|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.075|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.065|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp443|SNS-032 15μM R08 exp443]]|0.064|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp532|TIC10 10μM R08 exp532]]|0.06|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.059|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp513|ONC212 0.15μM R08 exp513]]|0.056|<button type="primary" size="small" modal="7">View</button>| |[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.087|<button type="primary" size="small" modal="8">View</button>| |[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.086|<button type="primary" size="small" modal="9">View</button>| |[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.079|<button type="primary" size="small" modal="10">View</button>| |[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.074|<button type="primary" size="small" modal="11">View</button>| |[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.067|<button type="primary" size="small" modal="12">View</button>| |[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.062|<button type="primary" size="small" modal="13">View</button>| |[[:results:exp539|42°C R08 exp539]]|0.059|<button type="primary" size="small" modal="14">View</button>| </modal> <modal id="1" size="lg" title="Hinokiflavone 12μM R08 exp487 vs PU-H71 1μM R08 exp515"> {{:chemogenomics:comparison_plots:exp487_vs_exp515.png?nolink |}} </modal> <modal id="2" size="lg" title="Hinokiflavone 12μM R08 exp487 vs THZ1 0.06μM R08 exp531"> {{:chemogenomics:comparison_plots:exp487_vs_exp531.png?nolink |}} </modal> <modal id="3" size="lg" title="Hinokiflavone 12μM R08 exp487 vs Vinblastine 0.2μM R03 exp108"> {{:chemogenomics:comparison_plots:exp108_vs_exp487.png?nolink |}} </modal> <modal id="4" size="lg" title="Hinokiflavone 12μM R08 exp487 vs SNS-032 15μM R08 exp443"> {{:chemogenomics:comparison_plots:exp443_vs_exp487.png?nolink |}} </modal> <modal id="5" size="lg" title="Hinokiflavone 12μM R08 exp487 vs TIC10 10μM R08 exp532"> {{:chemogenomics:comparison_plots:exp487_vs_exp532.png?nolink |}} </modal> <modal id="6" size="lg" title="Hinokiflavone 12μM R08 exp487 vs Tanespimycin 14μM R08 exp527"> {{:chemogenomics:comparison_plots:exp487_vs_exp527.png?nolink |}} </modal> <modal id="7" size="lg" title="Hinokiflavone 12μM R08 exp487 vs ONC212 0.15μM R08 exp513"> {{:chemogenomics:comparison_plots:exp487_vs_exp513.png?nolink |}} </modal> <modal id="8" size="lg" title="Atovaquone 15μM R08 exp451 vs Hinokiflavone 12μM R08 exp487"> {{:chemogenomics:comparison_plots:exp451_vs_exp487.png?nolink |}} </modal> <modal id="9" size="lg" title="BI-2536 0.02μM R03 exp96 vs Hinokiflavone 12μM R08 exp487"> {{:chemogenomics:comparison_plots:exp487_vs_exp96.png?nolink |}} </modal> <modal id="10" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448 vs Hinokiflavone 12μM R08 exp487"> {{:chemogenomics:comparison_plots:exp448_vs_exp487.png?nolink |}} </modal> <modal id="11" size="lg" title="GSK461364A 0.1μM R03 exp126 vs Hinokiflavone 12μM R08 exp487"> {{:chemogenomics:comparison_plots:exp126_vs_exp487.png?nolink |}} </modal> <modal id="12" size="lg" title="CR131-b 0.005μM R08 exp474 vs Hinokiflavone 12μM R08 exp487"> {{:chemogenomics:comparison_plots:exp474_vs_exp487.png?nolink |}} </modal> <modal id="13" size="lg" title="BI-6727 0.04μM R03 exp98 vs Hinokiflavone 12μM R08 exp487"> {{:chemogenomics:comparison_plots:exp487_vs_exp98.png?nolink |}} </modal> <modal id="14" size="lg" title="42°C R08 exp539 vs Hinokiflavone 12μM R08 exp487"> {{:chemogenomics:comparison_plots:exp487_vs_exp539.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms"> ^GO Term^Fold Change^Genes^ |positive regulation of mitotic sister chromatid separation|112.46|AURKB,ESPL1,CDCA8| |proteasome regulatory particle|106.21|PSMC2,PSMD3,PSMC3| </modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms"> ^GO Term^Fold Change^Genes^ |phosphotransferase activity, for other substituted phosphate groups|105.20|DPAGT1,AASDHPPT,PTDSS1,CEPT1| </modal> Last modified: 2026/01/15 21:36by 127.0.0.1