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Ask your administrator if you think this is wrong. ====== Hippuristanol 0.12μM R08 exp488 ====== ==== Mechanism of Action ==== Inhibits translation by trapping EIF4A on mRNA at poly-purine sites * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / Translation Inhibitor ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%Hippuristanol%% * **<color #00a2e8>Synonyms:</color>** N/A * **<color #00a2e8>CAS #:</color>** 80442-78-0 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/9981822|9981822]] * **<color #00a2e8>IUPAC:</color>** %%(1S,2S,3'S,4S,6R,7R,8R,9S,11S,12S,13S,16R,18S)-2',2',3',7,9,13-hexamethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,5'-oxolane]-7,11,16-triol%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 * **<color #00a2e8>INCHI Key:</color>** HPHXKNOXVBFETI-SHCCRYCOSA-N * **<color #00a2e8>Molecular Weight:</color>** 462.7 * **<color #00a2e8>Canonical SMILES:</color>** CC1CC2(C(C3C(O2)CC4C3(CC(C5C4CCC6C5(CCC(C6)O)C)O)C)(C)O)OC1(C)C * **<color #00a2e8>Isomeric SMILES:</color>** C[C@H]1C[C@]2([C@]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(C[C@@H]([C@H]5[C@H]4CC[C@@H]6[C@@]5(CC[C@H](C6)O)C)O)C)(C)O)OC1(C)C * **<color #00a2e8>Molecular Formula:</color>** C28H46O5 {{:chemogenomics:structures:chem-0297.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** In house - McGill University - Jerry Pelletier group * **<color #00a2e8>Catalog #:</color>** N/A * **<color #00a2e8>Lot #:</color>** N/A </panel> <panel title='Compound Characterization' collapsed='true'> * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C28H46O5 485.32375; found 485.31999 </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** Hippuristanol * **<color #00a2e8>Min:</color>** -26.3565; **<color #00a2e8>Max:</color>** 90.5289 {{:chemogenomics:dose_response:dr_544.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |0.0839 | | IC20 |0.1055 | | IC30 |0.1229 | | IC40 |0.1392 | | IC50 |0.1561 | | IC60 |0.1751 | | IC70 |0.1984 | | IC80 |0.2310 | | IC90 |0.2906 | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 08 * **<color #00a2e8>Dose</color>**: 120nM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: 0.3 * **<color #00a2e8>Numbers of reads</color>**: 16260685 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |9/126|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Hippuristanol_0.12uM_Round-8_exp488.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='Hippuristanol 0.12μM R08 exp488'> {{:chemogenomics:cranks_plots:exp488.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:C:CHMP2A|CHMP2A]]|-4.14|<0.01| |[[:human_genes:D:DDX3X|DDX3X]]|-3.85|<0.01| |[[:human_genes:P:POLR2L|POLR2L]]|-3.45|0.18| |[[:human_genes:A:ARL1|ARL1]]|-3.12|<0.01| |[[:human_genes:T:TCF4|TCF4]]|-3.11|<0.01| |[[:human_genes:S:SPI1|SPI1]]|-3.01|<0.01| |[[:human_genes:F:FZR1|FZR1]]|-2.98|<0.01| |[[:human_genes:X:XPR1|XPR1]]|-2.95|<0.01| |[[:human_genes:T:TSSC1|TSSC1]]|-2.91|<0.01| |[[:human_genes:S:SMG5|SMG5]]|-2.77|0.25| |[[:human_genes:P:PSME3|PSME3]]|-2.68|0.04| |[[:human_genes:V:VPS25|VPS25]]|-2.47|0.42| |[[:human_genes:S:SRSF10|SRSF10]]|-2.45|0.14| |[[:human_genes:Y:YY1|YY1]]|-2.44|0.14| |[[:human_genes:I:IPO11|IPO11]]|-2.44|0.06| |[[:human_genes:P:PCOLCE2|PCOLCE2]]|-2.42|0.09| |[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.41|0.06| |[[:human_genes:R:RHOA|RHOA]]|-2.38|0.07| |[[:human_genes:A:ACO2|ACO2]]|-2.36|0.07| |[[:human_genes:I:ING1|ING1]]|-2.34|0.07| |[[:human_genes:E:EIF4G2|EIF4G2]]|-2.30|0.08| |[[:human_genes:K:KPNB1|KPNB1]]|-2.29|0.38| |[[:human_genes:M:MED13|MED13]]|-2.27|0.14| |[[:human_genes:N:NSA2|NSA2]]|-2.26|0.41| |[[:human_genes:N:NUDT2|NUDT2]]|-2.26|0.10| |[[:human_genes:T:TP53BP1|TP53BP1]]|-2.24|0.15| |[[:human_genes:T:TUBB|TUBB]]|-2.24|0.21| |[[:human_genes:A:AMPD1|AMPD1]]|-2.22|0.12| |[[:human_genes:P:PKN1|PKN1]]|-2.18|0.13| |[[:human_genes:C:C16orf46|C16orf46]]|-2.18|0.23| |[[:human_genes:V:VDAC2|VDAC2]]|3.37|0.00| |[[:human_genes:E:EIF4ENIF1|EIF4ENIF1]]|3.38|0.00| |[[:human_genes:T:TSC1|TSC1]]|3.44|0.00| |[[:human_genes:H:HNRNPF|HNRNPF]]|3.55|0.00| |[[:human_genes:K:KTI12|KTI12]]|3.55|0.00| |[[:human_genes:S:SUV420H1|SUV420H1]]|3.58|0.00| |[[:human_genes:P:PRKACA|PRKACA]]|3.64|0.00| |[[:human_genes:R:ROMO1|ROMO1]]|3.66|0.00| |[[:human_genes:K:KLF16|KLF16]]|3.72|0.00| |[[:human_genes:M:MOCS3|MOCS3]]|3.73|0.00| |[[:human_genes:P:PLAA|PLAA]]|3.85|0.00| |[[:human_genes:U:USP1|USP1]]|3.86|0.00| |[[:human_genes:C:CEPT1|CEPT1]]|3.88|0.00| |[[:human_genes:L:LPAR5|LPAR5]]|3.93|0.00| |[[:human_genes:H:HDAC3|HDAC3]]|3.94|0.00| |[[:human_genes:M:MARCH5|MARCH5]]|3.96|0.00| |[[:human_genes:P:PCBP2|PCBP2]]|4.02|0.00| |[[:human_genes:S:SYK|SYK]]|4.06|0.00| |[[:human_genes:E:ELP6|ELP6]]|4.10|0.00| |[[:human_genes:M:MAPKAP1|MAPKAP1]]|4.14|0.00| |[[:human_genes:A:ALAS1|ALAS1]]|4.23|0.00| |[[:human_genes:R:RICTOR|RICTOR]]|4.27|0.00| |[[:human_genes:C:CD19|CD19]]|4.27|0.00| |[[:human_genes:P:PIK3CD|PIK3CD]]|4.27|0.00| |[[:human_genes:B:BCL2L11|BCL2L11]]|4.29|0.00| |[[:human_genes:T:TSC2|TSC2]]|4.68|0.00| |[[:human_genes:E:ELP3|ELP3]]|4.74|0.00| |[[:human_genes:A:APAF1|APAF1]]|5.20|0.00| |[[:human_genes:B:BAK1|BAK1]]|5.83|0.00| |[[:human_genes:E:EIF4A1|EIF4A1]]|7.61|0.00| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.49|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp134|MS023 2μM R03 exp134]]|0.162|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp135|MS023 7μM R03 exp135]]|0.14|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.118|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp512|Olaparib 4μM R08 exp512]]|0.115|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.106|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.099|<button type="primary" size="small" modal="7">View</button>| |[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.096|<button type="primary" size="small" modal="8">View</button>| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.093|<button type="primary" size="small" modal="9">View</button>| |[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.092|<button type="primary" size="small" modal="10">View</button>| |[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.083|<button type="primary" size="small" modal="11">View</button>| |[[:results:exp515|PU-H71 1μM R08 exp515]]|0.081|<button type="primary" size="small" modal="12">View</button>| |[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.08|<button type="primary" size="small" modal="13">View</button>| |[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.08|<button type="primary" size="small" modal="14">View</button>| |[[:results:exp492|iCRT14 30μM R08 exp492]]|0.077|<button type="primary" size="small" modal="15">View</button>| |[[:results:exp443|SNS-032 15μM R08 exp443]]|0.076|<button type="primary" size="small" modal="16">View</button>| |[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.074|<button type="primary" size="small" modal="17">View</button>| |[[:results:exp85|UM0129480 7μM R02 exp85]]|0.069|<button type="primary" size="small" modal="18">View</button>| |[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.069|<button type="primary" size="small" modal="19">View</button>| |[[:results:exp504|MK2206 4μM R08 exp504]]|0.068|<button type="primary" size="small" modal="20">View</button>| |[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.068|<button type="primary" size="small" modal="21">View</button>| |[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.066|<button type="primary" size="small" modal="22">View</button>| |[[:results:exp502|Milciclib 2μM R08 exp502]]|0.065|<button type="primary" size="small" modal="23">View</button>| |[[:results:exp240|Pyridostatin 4μM R05 exp240]]|0.063|<button type="primary" size="small" modal="24">View</button>| |[[:results:exp30|Rapamycin 10μM R00 exp30]]|0.063|<button type="primary" size="small" modal="25">View</button>| |[[:results:exp34|Rotenone 20μM R00 exp34]]|0.061|<button type="primary" size="small" modal="26">View</button>| |[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.06|<button type="primary" size="small" modal="27">View</button>| |[[:results:exp439|QNZ 0.01μM R08 exp439]]|0.059|<button type="primary" size="small" modal="28">View</button>| |[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.057|<button type="primary" size="small" modal="29">View</button>| |[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|0.057|<button type="primary" size="small" modal="30">View</button>| |[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.057|<button type="primary" size="small" modal="31">View</button>| |[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|0.056|<button type="primary" size="small" modal="32">View</button>| |[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|0.056|<button type="primary" size="small" modal="33">View</button>| |[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.055|<button type="primary" size="small" modal="34">View</button>| |[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.055|<button type="primary" size="small" modal="35">View</button>| |[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|0.054|<button type="primary" size="small" modal="36">View</button>| |[[:results:exp306|Rapamycin 2μM R07 exp306]]|0.052|<button type="primary" size="small" modal="37">View</button>| |[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|0.052|<button type="primary" size="small" modal="38">View</button>| |[[:results:exp431|Rotenone 0.07μM R08 exp431]]|0.052|<button type="primary" size="small" modal="39">View</button>| |[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.146|<button type="primary" size="small" modal="40">View</button>| |[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.142|<button type="primary" size="small" modal="41">View</button>| |[[:results:exp116|AICAR 240μM R03 exp116]]|0.102|<button type="primary" size="small" modal="42">View</button>| |[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.1|<button type="primary" size="small" modal="43">View</button>| |[[:results:exp485|GSK626616 14μM R08 exp485]]|0.096|<button type="primary" size="small" modal="44">View</button>| |[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.091|<button type="primary" size="small" modal="45">View</button>| |[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.09|<button type="primary" size="small" modal="46">View</button>| |[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.085|<button type="primary" size="small" modal="47">View</button>| |[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.084|<button type="primary" size="small" modal="48">View</button>| |[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.083|<button type="primary" size="small" modal="49">View</button>| |[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.081|<button type="primary" size="small" modal="50">View</button>| |[[:results:exp264|Arsenate 40μM R06 exp264]]|0.08|<button type="primary" size="small" modal="51">View</button>| |[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.079|<button type="primary" size="small" modal="52">View</button>| |[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.077|<button type="primary" size="small" modal="53">View</button>| |[[:results:exp275|Citral 75μM R06 exp275]]|0.076|<button type="primary" size="small" modal="54">View</button>| |[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.074|<button type="primary" size="small" modal="55">View</button>| |[[:results:exp216|Erlotinib 10μM R05 exp216]]|0.074|<button type="primary" size="small" modal="56">View</button>| |[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.074|<button type="primary" size="small" modal="57">View</button>| |[[:results:exp211|AICAR 240μM R05 exp211]]|0.073|<button type="primary" size="small" modal="58">View</button>| |[[:results:exp539|42°C R08 exp539]]|0.07|<button type="primary" size="small" modal="59">View</button>| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.07|<button type="primary" size="small" modal="60">View</button>| |[[:results:exp447|Amiloride 100μM R08 exp447]]|0.066|<button type="primary" size="small" modal="61">View</button>| |[[:results:exp19|Etoposide 1μM R00 exp19]]|0.066|<button type="primary" size="small" modal="62">View</button>| |[[:results:exp274|Citral 50μM R06 exp274]]|0.064|<button type="primary" size="small" modal="63">View</button>| |[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.063|<button type="primary" size="small" modal="64">View</button>| |[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.062|<button type="primary" size="small" modal="65">View</button>| |[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.062|<button type="primary" size="small" modal="66">View</button>| |[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.061|<button type="primary" size="small" modal="67">View</button>| |[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.06|<button type="primary" size="small" modal="68">View</button>| |[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.059|<button type="primary" size="small" modal="69">View</button>| |[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.058|<button type="primary" size="small" modal="70">View</button>| |[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|0.057|<button type="primary" size="small" modal="71">View</button>| |[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|0.055|<button type="primary" size="small" modal="72">View</button>| </modal> <modal id="1" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Hippuristanol 0.12μM R08 exp489 no dilution day6"> {{:chemogenomics:comparison_plots:exp488_vs_exp489.png?nolink |}} </modal> <modal id="2" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs MS023 2μM R03 exp134"> {{:chemogenomics:comparison_plots:exp134_vs_exp488.png?nolink |}} </modal> <modal id="3" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs MS023 7μM R03 exp135"> {{:chemogenomics:comparison_plots:exp135_vs_exp488.png?nolink |}} </modal> <modal id="4" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Staurosporine 0.02μM R08 exp524"> {{:chemogenomics:comparison_plots:exp488_vs_exp524.png?nolink |}} </modal> <modal id="5" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Olaparib 4μM R08 exp512"> {{:chemogenomics:comparison_plots:exp488_vs_exp512.png?nolink |}} </modal> <modal id="6" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Mitomycin-C 0.06μM R08 exp503"> {{:chemogenomics:comparison_plots:exp488_vs_exp503.png?nolink |}} </modal> <modal id="7" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Trimetrexate 0.03μM R08 exp535"> {{:chemogenomics:comparison_plots:exp488_vs_exp535.png?nolink |}} </modal> <modal id="8" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Sulforaphane 9μM R08 exp525"> {{:chemogenomics:comparison_plots:exp488_vs_exp525.png?nolink |}} </modal> <modal id="9" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs THZ1 0.06μM R08 exp531"> {{:chemogenomics:comparison_plots:exp488_vs_exp531.png?nolink |}} </modal> <modal id="10" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Sulforaphane 9μM R08 exp526 no dilution day6"> {{:chemogenomics:comparison_plots:exp488_vs_exp526.png?nolink |}} </modal> <modal id="11" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Thimerosal 0.85μM R08 exp529"> {{:chemogenomics:comparison_plots:exp488_vs_exp529.png?nolink |}} </modal> <modal id="12" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs PU-H71 1μM R08 exp515"> {{:chemogenomics:comparison_plots:exp488_vs_exp515.png?nolink |}} </modal> <modal id="13" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Pimelic-diphenylamide-106 5μM R00 exp28"> {{:chemogenomics:comparison_plots:exp28_vs_exp488.png?nolink |}} </modal> <modal id="14" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs JQ1 0.8μM R08 exp435"> {{:chemogenomics:comparison_plots:exp435_vs_exp488.png?nolink |}} </modal> <modal id="15" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs iCRT14 30μM R08 exp492"> {{:chemogenomics:comparison_plots:exp488_vs_exp492.png?nolink |}} </modal> <modal id="16" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs SNS-032 15μM R08 exp443"> {{:chemogenomics:comparison_plots:exp443_vs_exp488.png?nolink |}} </modal> <modal id="17" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs MLN-4924 0.2μM R00 exp21"> {{:chemogenomics:comparison_plots:exp21_vs_exp488.png?nolink |}} </modal> <modal id="18" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs UM0129480 7μM R02 exp85"> {{:chemogenomics:comparison_plots:exp488_vs_exp85.png?nolink |}} </modal> <modal id="19" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Latrunculin-B 10μM R07 exp374"> {{:chemogenomics:comparison_plots:exp374_vs_exp488.png?nolink |}} </modal> <modal id="20" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs MK2206 4μM R08 exp504"> {{:chemogenomics:comparison_plots:exp488_vs_exp504.png?nolink |}} </modal> <modal id="21" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Thapsigargin 0.005μM R07 exp407"> {{:chemogenomics:comparison_plots:exp407_vs_exp488.png?nolink |}} </modal> <modal id="22" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs RO-3307 4.7μM R02 exp80"> {{:chemogenomics:comparison_plots:exp488_vs_exp80.png?nolink |}} </modal> <modal id="23" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Milciclib 2μM R08 exp502"> {{:chemogenomics:comparison_plots:exp488_vs_exp502.png?nolink |}} </modal> <modal id="24" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Pyridostatin 4μM R05 exp240"> {{:chemogenomics:comparison_plots:exp240_vs_exp488.png?nolink |}} </modal> <modal id="25" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Rapamycin 10μM R00 exp30"> {{:chemogenomics:comparison_plots:exp30_vs_exp488.png?nolink |}} </modal> <modal id="26" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Rotenone 20μM R00 exp34"> {{:chemogenomics:comparison_plots:exp34_vs_exp488.png?nolink |}} </modal> <modal id="27" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Tanespimycin 14μM R08 exp527"> {{:chemogenomics:comparison_plots:exp488_vs_exp527.png?nolink |}} </modal> <modal id="28" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs QNZ 0.01μM R08 exp439"> {{:chemogenomics:comparison_plots:exp439_vs_exp488.png?nolink |}} </modal> <modal id="29" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Lead acetate 2000μM R08 exp497"> {{:chemogenomics:comparison_plots:exp488_vs_exp497.png?nolink |}} </modal> <modal id="30" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Mubritinib 0.2μM R01 exp48"> {{:chemogenomics:comparison_plots:exp48_vs_exp488.png?nolink |}} </modal> <modal id="31" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Lead acetate 2000μM R08 exp498 no dilution day6"> {{:chemogenomics:comparison_plots:exp488_vs_exp498.png?nolink |}} </modal> <modal id="32" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Tozasertib 0.1μM R07 exp414"> {{:chemogenomics:comparison_plots:exp414_vs_exp488.png?nolink |}} </modal> <modal id="33" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Nifuroxazide 5μM R03 exp102"> {{:chemogenomics:comparison_plots:exp102_vs_exp488.png?nolink |}} </modal> <modal id="34" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Nutlin-3A 1.6μM R06 exp294"> {{:chemogenomics:comparison_plots:exp294_vs_exp488.png?nolink |}} </modal> <modal id="35" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp488_vs_exp500.png?nolink |}} </modal> <modal id="36" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Phorbol-12-myristate-13-acetate 0.57μM R08 exp514"> {{:chemogenomics:comparison_plots:exp488_vs_exp514.png?nolink |}} </modal> <modal id="37" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Rapamycin 2μM R07 exp306"> {{:chemogenomics:comparison_plots:exp306_vs_exp488.png?nolink |}} </modal> <modal id="38" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Oligomycin-A 2μM R00 exp25"> {{:chemogenomics:comparison_plots:exp25_vs_exp488.png?nolink |}} </modal> <modal id="39" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs Rotenone 0.07μM R08 exp431"> {{:chemogenomics:comparison_plots:exp431_vs_exp488.png?nolink |}} </modal> <modal id="40" size="lg" title="Aphidicolin 0.4μM R08 exp440 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp440_vs_exp488.png?nolink |}} </modal> <modal id="41" size="lg" title="Benzoate 20000μM R08 exp456 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp456_vs_exp488.png?nolink |}} </modal> <modal id="42" size="lg" title="AICAR 240μM R03 exp116 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp116_vs_exp488.png?nolink |}} </modal> <modal id="43" size="lg" title="Ethanol 0.01 R05 exp234 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp234_vs_exp488.png?nolink |}} </modal> <modal id="44" size="lg" title="GSK626616 14μM R08 exp485 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp485_vs_exp488.png?nolink |}} </modal> <modal id="45" size="lg" title="CR131-b 0.005μM R08 exp474 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp474_vs_exp488.png?nolink |}} </modal> <modal id="46" size="lg" title="Doxorubicin 0.02μM R08 exp478 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp478_vs_exp488.png?nolink |}} </modal> <modal id="47" size="lg" title="CI-1040 9.5μM R08 exp472 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp472_vs_exp488.png?nolink |}} </modal> <modal id="48" size="lg" title="Dorsomorphin 5μM R07 exp357 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp357_vs_exp488.png?nolink |}} </modal> <modal id="49" size="lg" title="Bleomycin 5μM R08 exp459 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp459_vs_exp488.png?nolink |}} </modal> <modal id="50" size="lg" title="Actinomycin-D 0.001μM R00 exp3 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp3_vs_exp488.png?nolink |}} </modal> <modal id="51" size="lg" title="Arsenate 40μM R06 exp264 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp264_vs_exp488.png?nolink |}} </modal> <modal id="52" size="lg" title="CB-5083 0.4μM R08 exp468 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp468_vs_exp488.png?nolink |}} </modal> <modal id="53" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp259_vs_exp488.png?nolink |}} </modal> <modal id="54" size="lg" title="Citral 75μM R06 exp275 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp275_vs_exp488.png?nolink |}} </modal> <modal id="55" size="lg" title="Etoposide 0.3μM R05 exp199 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp199_vs_exp488.png?nolink |}} </modal> <modal id="56" size="lg" title="Erlotinib 10μM R05 exp216 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp216_vs_exp488.png?nolink |}} </modal> <modal id="57" size="lg" title="Artemisinin 50μM R08 exp450 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp450_vs_exp488.png?nolink |}} </modal> <modal id="58" size="lg" title="AICAR 240μM R05 exp211 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp211_vs_exp488.png?nolink |}} </modal> <modal id="59" size="lg" title="42°C R08 exp539 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp488_vs_exp539.png?nolink |}} </modal> <modal id="60" size="lg" title="5-Fluorouracil 20μM R00 exp2 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp2_vs_exp488.png?nolink |}} </modal> <modal id="61" size="lg" title="Amiloride 100μM R08 exp447 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp447_vs_exp488.png?nolink |}} </modal> <modal id="62" size="lg" title="Etoposide 1μM R00 exp19 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp19_vs_exp488.png?nolink |}} </modal> <modal id="63" size="lg" title="Citral 50μM R06 exp274 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp274_vs_exp488.png?nolink |}} </modal> <modal id="64" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp445_vs_exp488.png?nolink |}} </modal> <modal id="65" size="lg" title="Cannabidiol 20μM R08 exp466 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp466_vs_exp488.png?nolink |}} </modal> <modal id="66" size="lg" title="Diepoxybutane 3μM R07 exp354 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp354_vs_exp488.png?nolink |}} </modal> <modal id="67" size="lg" title="GSK-J4 1.5μM R08 exp441 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp441_vs_exp488.png?nolink |}} </modal> <modal id="68" size="lg" title="Dinaciclib 0.007μM R07 exp355 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp355_vs_exp488.png?nolink |}} </modal> <modal id="69" size="lg" title="Atovaquone 15μM R08 exp451 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp451_vs_exp488.png?nolink |}} </modal> <modal id="70" size="lg" title="Centrinone 0.5μM R07 exp343 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp343_vs_exp488.png?nolink |}} </modal> <modal id="71" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp214_vs_exp488.png?nolink |}} </modal> <modal id="72" size="lg" title="Cytochalasin-B 5μM R07 exp349 vs Hippuristanol 0.12μM R08 exp488"> {{:chemogenomics:comparison_plots:exp349_vs_exp488.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms"> ^GO Term^Fold Change^Genes^ |porin activity|220.92|BAK1,VDAC2| |elongator holoenzyme complex|220.92|ELP3,ELP6| |positive regulation of IRE1-mediated unfolded protein response|184.10|BAK1,BCL2L11| |TORC2 signaling|184.10|RICTOR,MAPKAP1| |tRNA wobble uridine modification|138.07|ELP3,ELP6,MOCS3,KTI12| |tRNA wobble base modification|116.27|ELP3,ELP6,MOCS3,KTI12| |positive regulation of mitochondrial membrane permeability|59.18|BAK1,BCL2L11,VDAC2| |positive regulation of membrane permeability|53.45|BAK1,BCL2L11,VDAC2| |neural tube closure|25.10|APAF1,TSC2,PRKACA,TSC1| |tRNA modification|24.82|ELP3,ELP6,MOCS3,KTI12| |tube closure|24.82|APAF1,TSC2,PRKACA,TSC1| |regulation of TOR signaling|24.55|TSC2,RICTOR,SYK,HDAC3,PRKACA,TSC1| |primary neural tube formation|23.50|APAF1,TSC2,PRKACA,TSC1| |neural tube formation|21.87|APAF1,TSC2,PRKACA,TSC1| |mitochondrial membrane organization|21.04|BAK1,BCL2L11,ROMO1,VDAC2| |tube formation|19.45|APAF1,TSC2,BCL2L11,PRKACA,TSC1| |nuclear transport|11.75|TSC2,SYK,PRKACA,TSC1,EIF4ENIF1| </modal> Last modified: 2026/01/15 21:36by 127.0.0.1