Show pageOld revisionsBacklinksFold/unfold allBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Hydroxychloroquine 30μM R08 exp490 ====== ==== Mechanism of Action ==== Lysosomotropic agent, prevents sequestration of heme into hemozoin, forms toxic complex with heme, also inhibits TLR 7/9 * **<color #00a2e8>Class / Subclass 1:</color>** Infectious Disease / Antimalarial * **<color #00a2e8>Class / Subclass 2:</color>** DNA Damage, Repair and Replication / Intercalating Agent * **<color #00a2e8>Class / Subclass 3:</color>** Proteostasis / Autophagy Inhibitor ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%Hydroxychloroquine sulfate%% * **<color #00a2e8>Synonyms:</color>** HCQ sulfate * **<color #00a2e8>CAS #:</color>** 747-36-4 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/12947|12947]] * **<color #00a2e8>IUPAC:</color>** %%2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol;sulfuric acid%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4) * **<color #00a2e8>INCHI Key:</color>** JCBIVZZPXRZKTI-UHFFFAOYSA-N * **<color #00a2e8>Molecular Weight:</color>** 434 * **<color #00a2e8>Canonical SMILES:</color>** CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O * **<color #00a2e8>Isomeric SMILES:</color>** N/A * **<color #00a2e8>Molecular Formula:</color>** C18H28ClN3O5S {{:chemogenomics:structures:chem-0298.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** Combi-Blocks * **<color #00a2e8>Catalog #:</color>** QA-8047 * **<color #00a2e8>Lot #:</color>** B11244 </panel> <panel title='Compound Characterization' collapsed='true'> Characterization data not available. </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** Hydroxychloroquine * **<color #00a2e8>Min:</color>** -11.2129; **<color #00a2e8>Max:</color>** 98.9777 {{:chemogenomics:dose_response:dr_545.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |18.4900 | | IC20 |24.0900 | | IC30 |28.7200 | | IC40 |33.1700 | | IC50 |37.8700 | | IC60 |43.2200 | | IC70 |49.9200 | | IC80 |59.5200 | | IC90 |77.5500 | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 08 * **<color #00a2e8>Dose</color>**: 30µM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: 6.2 * **<color #00a2e8>Numbers of reads</color>**: 16492093 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |9/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Hydroxychloroquine_30uM_Round-8_exp490.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='Hydroxychloroquine 30μM R08 exp490'> {{:chemogenomics:cranks_plots:exp490.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:O:ODC1|ODC1]]|-4.41|<0.01| |[[:human_genes:F:FLVCR1|FLVCR1]]|-3.20|<0.01| |[[:human_genes:K:KAT7|KAT7]]|-3.02|<0.01| |[[:human_genes:W:WDR81|WDR81]]|-2.94|0.01| |[[:human_genes:R:RAB7A|RAB7A]]|-2.88|<0.01| |[[:human_genes:S:SLC5A3|SLC5A3]]|-2.61|0.03| |[[:human_genes:U:UBA3|UBA3]]|-2.59|0.09| |[[:human_genes:A:ARL1|ARL1]]|-2.51|0.05| |[[:human_genes:S:SLC25A1|SLC25A1]]|-2.49|0.05| |[[:human_genes:C:CDIPT|CDIPT]]|-2.47|0.21| |[[:human_genes:A:ADIPOR2|ADIPOR2]]|-2.46|0.05| |[[:human_genes:S:SLC39A9|SLC39A9]]|-2.43|0.05| |[[:human_genes:M:MARCKSL1|MARCKSL1]]|-2.43|0.05| |[[:human_genes:F:FIGNL2|FIGNL2]]|-2.38|0.06| |[[:human_genes:C:COMMD10|COMMD10]]|-2.38|0.06| |[[:human_genes:U:UHRF1|UHRF1]]|-2.38|0.17| |[[:human_genes:C:CCDC22|CCDC22]]|-2.28|0.09| |[[:human_genes:M:MGA|MGA]]|-2.28|0.09| |[[:human_genes:D:DOT1L|DOT1L]]|-2.26|0.09| |[[:human_genes:C:CNOT4|CNOT4]]|-2.25|0.09| |[[:human_genes:C:COMMD5|COMMD5]]|-2.23|0.10| |[[:human_genes:B:BTN2A1|BTN2A1]]|-2.20|0.26| |[[:human_genes:P:PEX7|PEX7]]|-2.18|0.12| |[[:human_genes:A:ANO4|ANO4]]|-2.17|0.21| |[[:human_genes:C:C6orf118|C6orf118]]|-2.17|0.26| |[[:human_genes:T:TAAR5|TAAR5]]|-2.16|0.13| |[[:human_genes:F:FDPS|FDPS]]|-2.13|0.23| |[[:human_genes:A:ATP2A2|ATP2A2]]|-2.11|0.73| |[[:human_genes:T:TMEM189|TMEM189]]|-2.11|0.17| |[[:human_genes:P:PROL1|PROL1]]|-2.07|0.19| |[[:human_genes:C:CDC40|CDC40]]|1.91|0.55| |[[:human_genes:A:ANKK1|ANKK1]]|1.92|0.55| |[[:human_genes:R:RCC1|RCC1]]|1.93|0.79| |[[:human_genes:M:MTHFD2|MTHFD2]]|1.94|0.55| |[[:human_genes:T:TAC4|TAC4]]|1.95|0.55| |[[:human_genes:U:USP39|USP39]]|1.95|0.79| |[[:human_genes:S:SURF1|SURF1]]|1.96|0.55| |[[:human_genes:D:DAGLA|DAGLA]]|1.96|0.55| |[[:human_genes:F:FRS2|FRS2]]|1.96|0.55| |[[:human_genes:T:TRIM44|TRIM44]]|1.99|0.55| |[[:human_genes:C:CCDC9|CCDC9]]|2.00|0.55| |[[:human_genes:T:TCEAL5|TCEAL5]]|2.01|0.55| |[[:human_genes:E:EXTL1|EXTL1]]|2.03|0.55| |[[:human_genes:F:FAM9B|FAM9B]]|2.04|0.55| |[[:human_genes:S:SREBF2|SREBF2]]|2.05|0.69| |[[:human_genes:N:NPRL2|NPRL2]]|2.06|0.55| |[[:human_genes:S:SHMT2|SHMT2]]|2.07|0.55| |[[:human_genes:I:ISY1|ISY1]]|2.10|0.71| |[[:human_genes:T:TMEM63C|TMEM63C]]|2.12|0.43| |[[:human_genes:N:NID1|NID1]]|2.14|0.43| |[[:human_genes:C:CPA2|CPA2]]|2.15|0.43| |[[:human_genes:N:NDUFA13|NDUFA13]]|2.17|0.55| |[[:human_genes:N:NEK3|NEK3]]|2.17|0.43| |[[:human_genes:S:SEC13|SEC13]]|2.18|0.69| |[[:human_genes:C:CSNK2A1|CSNK2A1]]|2.22|0.43| |[[:human_genes:P:PTGIS|PTGIS]]|2.24|0.43| |[[:human_genes:Z:ZNF91|ZNF91]]|2.27|0.43| |[[:human_genes:E:EIF2S1|EIF2S1]]|2.52|0.77| |[[:human_genes:G:GTPBP4|GTPBP4]]|2.57|0.43| |[[:human_genes:M:MAT2B|MAT2B]]|2.60|0.22| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.096|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.095|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.069|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp470|Chloroquine 32μM R08 exp470]]|0.098|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp483|FTY720 3μM R08 exp483]]|0.082|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp453|B02 10μM R08 exp453]]|0.063|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.061|<button type="primary" size="small" modal="7">View</button>| |[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.059|<button type="primary" size="small" modal="8">View</button>| |[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.053|<button type="primary" size="small" modal="9">View</button>| |[[:results:exp452|Azithromycin 100μM R08 exp452]]|0.052|<button type="primary" size="small" modal="10">View</button>| </modal> <modal id="1" size="lg" title="Hydroxychloroquine 30μM R08 exp490 vs Thioridazine 5μM R08 exp530"> {{:chemogenomics:comparison_plots:exp490_vs_exp530.png?nolink |}} </modal> <modal id="2" size="lg" title="Hydroxychloroquine 30μM R08 exp490 vs NN-Dimethylsphingosine 2.5μM R08 exp508"> {{:chemogenomics:comparison_plots:exp490_vs_exp508.png?nolink |}} </modal> <modal id="3" size="lg" title="Hydroxychloroquine 30μM R08 exp490 vs Prochlorperazine 5.2μM R02 exp77"> {{:chemogenomics:comparison_plots:exp490_vs_exp77.png?nolink |}} </modal> <modal id="4" size="lg" title="Chloroquine 32μM R08 exp470 vs Hydroxychloroquine 30μM R08 exp490"> {{:chemogenomics:comparison_plots:exp470_vs_exp490.png?nolink |}} </modal> <modal id="5" size="lg" title="FTY720 3μM R08 exp483 vs Hydroxychloroquine 30μM R08 exp490"> {{:chemogenomics:comparison_plots:exp483_vs_exp490.png?nolink |}} </modal> <modal id="6" size="lg" title="B02 10μM R08 exp453 vs Hydroxychloroquine 30μM R08 exp490"> {{:chemogenomics:comparison_plots:exp453_vs_exp490.png?nolink |}} </modal> <modal id="7" size="lg" title="Cannabidiol 13μM R08 exp465 vs Hydroxychloroquine 30μM R08 exp490"> {{:chemogenomics:comparison_plots:exp465_vs_exp490.png?nolink |}} </modal> <modal id="8" size="lg" title="Bisphenol F 50μM R08 exp457 vs Hydroxychloroquine 30μM R08 exp490"> {{:chemogenomics:comparison_plots:exp457_vs_exp490.png?nolink |}} </modal> <modal id="9" size="lg" title="Bafilomycin-A1 0.009μM R08 exp454 vs Hydroxychloroquine 30μM R08 exp490"> {{:chemogenomics:comparison_plots:exp454_vs_exp490.png?nolink |}} </modal> <modal id="10" size="lg" title="Azithromycin 100μM R08 exp452 vs Hydroxychloroquine 30μM R08 exp490"> {{:chemogenomics:comparison_plots:exp452_vs_exp490.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal> Last modified: 2026/01/15 21:36by 127.0.0.1