iCRT14 30μM R08 exp492 [The Human Chemical-Genetic Interaction Map Project]

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====== iCRT14 30μM R08 exp492 ======
==== Mechanism of Action ====
Inhibits β-catenin-dependent transcription, may alter interaction of β-catenin with TCF4
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Transcription Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%CID 5967294%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 677331-12-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5967294|5967294]]
    * **<color #00a2e8>IUPAC:</color>** %%(5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
    * **<color #00a2e8>INCHI Key:</color>** NCSHZXNGQYSKLR-UNOMPAQXSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 375.4
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=CC(=C(N1C2=CN=CC=C2)C)C=C3C(=O)N(C(=O)S3)C4=CC=CC=C4
    * **<color #00a2e8>Isomeric SMILES:</color>** CC1=CC(=C(N1C2=CN=CC=C2)C)/C=C\\3/C(=O)N(C(=O)S3)C4=CC=CC=C4
    * **<color #00a2e8>Molecular Formula:</color>** C21H17N3O2S
{{:chemogenomics:structures:chem-0300.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-16665
    * **<color #00a2e8>Lot #:</color>** 23429
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C21H17N3O2S 376.11142; found 376.11235
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** iCRT14
    * **<color #00a2e8>Min:</color>** -11.0010; **<color #00a2e8>Max:</color>** 69.6272
{{:chemogenomics:dose_response:dr_547.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |4.0980    |
| IC20  |8.5500    |
| IC30  |13.9400    |
| IC40  |20.8100    |
| IC50  |30.0600    |
| IC60  |43.4100    |
| IC70  |64.8100    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 30µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.2
    * **<color #00a2e8>Numbers of reads</color>**: 17101968


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|12/56|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/iCRT14_30uM_Round-8_exp492.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='iCRT14 30μM R08 exp492'>
{{:chemogenomics:cranks_plots:exp492.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:G:GOT1|GOT1]]|-3.77|<0.01|
|[[:human_genes:P:PRKAG1|PRKAG1]]|-3.72|<0.01|
|[[:human_genes:D:DERL2|DERL2]]|-3.50|<0.01|
|[[:human_genes:F:FAM3A|FAM3A]]|-3.30|<0.01|
|[[:human_genes:R:RPS17L|RPS17L]]|-3.28|0.04|
|[[:human_genes:S:SNX27|SNX27]]|-3.10|<0.01|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-2.98|<0.01|
|[[:human_genes:M:MGA|MGA]]|-2.82|<0.01|
|[[:human_genes:U:URB1|URB1]]|-2.81|0.08|
|[[:human_genes:C:CDK2|CDK2]]|-2.78|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-2.77|<0.01|
|[[:human_genes:C:CMC2|CMC2]]|-2.66|0.16|
|[[:human_genes:P:PLK1|PLK1]]|-2.60|0.31|
|[[:human_genes:P:PLD3|PLD3]]|-2.59|0.02|
|[[:human_genes:Z:ZBTB1|ZBTB1]]|-2.56|0.05|
|[[:human_genes:U:UXS1|UXS1]]|-2.54|0.03|
|[[:human_genes:M:MNT|MNT]]|-2.51|0.06|
|[[:human_genes:C:CDC20|CDC20]]|-2.45|0.16|
|[[:human_genes:P:POLA1|POLA1]]|-2.38|0.30|
|[[:human_genes:O:OGT|OGT]]|-2.36|0.31|
|[[:human_genes:Z:ZFAND2B|ZFAND2B]]|-2.32|0.12|
|[[:human_genes:T:THOC2|THOC2]]|-2.32|0.15|
|[[:human_genes:S:SLC16A10|SLC16A10]]|-2.27|0.08|
|[[:human_genes:D:DOT1L|DOT1L]]|-2.27|0.08|
|[[:human_genes:R:RAB7A|RAB7A]]|-2.27|0.08|
|[[:human_genes:H:HMGCS1|HMGCS1]]|-2.24|0.15|
|[[:human_genes:Y:YPEL5|YPEL5]]|-2.21|0.11|
|[[:human_genes:K:KEAP1|KEAP1]]|-2.20|0.15|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.19|0.15|
|[[:human_genes:O:OR13G1|OR13G1]]|-2.19|0.12|
|[[:human_genes:Z:ZBTB18|ZBTB18]]|2.55|0.01|
|[[:human_genes:A:ALG13|ALG13]]|2.57|0.02|
|[[:human_genes:P:PMAIP1|PMAIP1]]|2.59|<0.01|
|[[:human_genes:Z:ZCRB1|ZCRB1]]|2.61|0.02|
|[[:human_genes:P:P4HB|P4HB]]|2.63|<0.01|
|[[:human_genes:H:HSD17B10|HSD17B10]]|2.70|0.01|
|[[:human_genes:S:SEC62|SEC62]]|2.76|<0.01|
|[[:human_genes:A:ALAS1|ALAS1]]|2.76|0.03|
|[[:human_genes:P:PET117|PET117]]|2.77|<0.01|
|[[:human_genes:P:PGM3|PGM3]]|2.77|<0.01|
|[[:human_genes:S:SLC25A51|SLC25A51]]|2.79|<0.01|
|[[:human_genes:R:RALGAPB|RALGAPB]]|2.82|<0.01|
|[[:human_genes:D:DPH1|DPH1]]|2.84|<0.01|
|[[:human_genes:A:ARRDC4|ARRDC4]]|2.86|<0.01|
|[[:human_genes:K:KCTD5|KCTD5]]|2.86|<0.01|
|[[:human_genes:K:KIAA0922|KIAA0922]]|2.89|<0.01|
|[[:human_genes:W:WBSCR16|WBSCR16]]|2.93|0.08|
|[[:human_genes:O:OMA1|OMA1]]|2.95|<0.01|
|[[:human_genes:M:MLEC|MLEC]]|2.97|<0.01|
|[[:human_genes:N:NDUFA2|NDUFA2]]|2.97|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|2.99|<0.01|
|[[:human_genes:N:NANS|NANS]]|3.04|<0.01|
|[[:human_genes:S:SYNCRIP|SYNCRIP]]|3.36|<0.01|
|[[:human_genes:S:STARD7|STARD7]]|3.38|<0.01|
|[[:human_genes:S:SPI1|SPI1]]|3.63|<0.01|
|[[:human_genes:M:MLX|MLX]]|3.65|<0.01|
|[[:human_genes:T:TMEM39A|TMEM39A]]|3.68|<0.01|
|[[:human_genes:C:CXorf56|CXorf56]]|3.72|<0.01|
|[[:human_genes:D:DDX3X|DDX3X]]|3.97|<0.01|
|[[:human_genes:P:PPP6C|PPP6C]]|3.97|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|0.095|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|0.091|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.09|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.088|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.077|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.074|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.074|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.073|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|0.071|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|0.069|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.069|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.067|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.066|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|0.066|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|0.064|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.063|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.063|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|0.06|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|0.06|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.06|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.058|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.057|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|0.057|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|0.057|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.057|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|0.057|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.056|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.055|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.055|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|0.054|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.053|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.053|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.052|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.052|<button type="primary" size="small" modal="34">View</button>|
</modal>


<modal id="1" size="lg" title="Oligomycin-A 2μM R00 exp25  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp25_vs_exp492.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Senexin-A 25μM R07 exp400  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp400_vs_exp492.png?nolink |}}
</modal>

<modal id="3" size="lg" title="UM0129480 7μM R02 exp85  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp85.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Thimerosal 0.85μM R08 exp529  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp529.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp488_vs_exp492.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Cannabidiol 20μM R08 exp466  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp466_vs_exp492.png?nolink |}}
</modal>

<modal id="7" size="lg" title="LLY-283 2.6μM R06 exp290  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp290_vs_exp492.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Trimetrexate 0.03μM R08 exp535  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp535.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Rotenone 0.07μM R08 exp431  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp431_vs_exp492.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Calcium Ionophore 0.4μM R07 exp342  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp342_vs_exp492.png?nolink |}}
</modal>

<modal id="11" size="lg" title="AICAR 240μM R03 exp116  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp116_vs_exp492.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Lead acetate 2000μM R08 exp497  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp497.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp498.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Amiloride 100μM R08 exp447  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp447_vs_exp492.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Mubritinib 0.2μM R02 exp65  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp65.png?nolink |}}
</modal>

<modal id="16" size="lg" title="FK-506 30μM R07 exp359  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp359_vs_exp492.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp440_vs_exp492.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Phenformin 20μM R05 exp212  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp212_vs_exp492.png?nolink |}}
</modal>

<modal id="19" size="lg" title="ONC212 0.15μM R08 exp513  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp513.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp357_vs_exp492.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Ethanol 0.01 R05 exp234  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp234_vs_exp492.png?nolink |}}
</modal>

<modal id="22" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp445_vs_exp492.png?nolink |}}
</modal>

<modal id="23" size="lg" title="QNZ 0.01μM R05 exp241  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp241_vs_exp492.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Chloroquine 32μM R08 exp470  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp470_vs_exp492.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp329_vs_exp492.png?nolink |}}
</modal>

<modal id="26" size="lg" title="QNZ 0.01μM R08 exp439  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp439_vs_exp492.png?nolink |}}
</modal>

<modal id="27" size="lg" title="UM0125461 0.74μM R02 exp84  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp84.png?nolink |}}
</modal>

<modal id="28" size="lg" title="CR131-b 0.005μM R08 exp474  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp474_vs_exp492.png?nolink |}}
</modal>

<modal id="29" size="lg" title="JQ1 0.8μM R08 exp435  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp435_vs_exp492.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Torin1 0.08μM R02 exp82  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp82.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Milciclib 2μM R08 exp502  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp502.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Thapsigargin 0.005μM R07 exp407  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp407_vs_exp492.png?nolink |}}
</modal>

<modal id="33" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp489_vs_exp492.png?nolink |}}
</modal>

<modal id="34" size="lg" title="GSK-J4 1.5μM R08 exp441  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp441_vs_exp492.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|regulation of anaphase-promoting complex-dependent catabolic process|443.81|CDK2,PLK1,CDC20|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|21.29|CDK2,PLK1,CDC20,OGT,KEAP1|
|regulation of ubiquitin-dependent protein catabolic process|16.91|CDK2,PLK1,CDC20,OGT,KEAP1|
|regulation of proteasomal protein catabolic process|15.65|CDK2,PLK1,CDC20,OGT,KEAP1|
|transferase complex|6.44|PRKAG1,DERL2,MGA,CDK2,CDC20,POLA1,OGT,YPEL5,KEAP1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>