Lead acetate 990μM R08 exp496 [The Human Chemical-Genetic Interaction Map Project]

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====== Lead acetate 990μM R08 exp496 ======
==== Mechanism of Action ====
Industrial pollutant, heavy metal toxin
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Heavy Metal




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Lead acetate trihydrate%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 6080-56-4
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/22456|22456]]
    * **<color #00a2e8>IUPAC:</color>** %%lead(2+);diacetate;trihydrate%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/2C2H4O2.3H2O.Pb/c2*1-2(3)4;;;;/h2*1H3,(H,3,4);3*1H2;/q;;;;;+2/p-2
    * **<color #00a2e8>INCHI Key:</color>** MCEUZMYFCCOOQO-UHFFFAOYSA-L
    * **<color #00a2e8>Molecular Weight:</color>** 379
    * **<color #00a2e8>Canonical SMILES:</color>** CC(=O)[O-].CC(=O)[O-].O.O.O.[Pb+2]
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C4H12O7Pb
{{:chemogenomics:structures:chem-0304.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** EM Science
    * **<color #00a2e8>Catalog #:</color>** LX0120-1
    * **<color #00a2e8>Lot #:</color>** 28147208
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>XRPD:</color>** Expected Pb(CH3COO)2 3H2O; found Pb(CH3COO)2 + 
Pb(CH3COO)2 3H2O
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Lead-Aceteate
    * **<color #00a2e8>Min:</color>** 2.9017; **<color #00a2e8>Max:</color>** 98.7157
{{:chemogenomics:dose_response:dr_435.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |1.3598    |
| IC30  |2.1266    |
| IC40  |3.0284    |
| IC50  |4.1663    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 990µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 4.7
    * **<color #00a2e8>Numbers of reads</color>**: 14387420


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|3/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Lead_acetate_990uM_Round-8_exp496.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Lead acetate 990μM R08 exp496'>
{{:chemogenomics:cranks_plots:exp496.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ADK|ADK]]|-3.58|<0.01|
|[[:human_genes:K:KDSR|KDSR]]|-2.84|0.02|
|[[:human_genes:R:RGS16|RGS16]]|-2.72|0.03|
|[[:human_genes:P:PPME1|PPME1]]|-2.72|0.06|
|[[:human_genes:S:SLC39A10|SLC39A10]]|-2.55|0.06|
|[[:human_genes:T:TCF4|TCF4]]|-2.43|0.10|
|[[:human_genes:M:MRPS33|MRPS33]]|-2.40|0.35|
|[[:human_genes:L:LOC100287177|LOC100287177]]|-2.37|0.12|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.33|0.13|
|[[:human_genes:V:VPS51|VPS51]]|-2.16|0.55|
|[[:human_genes:M:MTFMT|MTFMT]]|-2.16|0.42|
|[[:human_genes:C:CNOT6|CNOT6]]|-2.13|0.35|
|[[:human_genes:T:TRIM22|TRIM22]]|-2.06|0.42|
|[[:human_genes:N:NDUFB3|NDUFB3]]|-2.06|0.47|
|[[:human_genes:S:SPTBN1|SPTBN1]]|-2.04|0.42|
|[[:human_genes:O:OR9Q1|OR9Q1]]|-2.03|0.42|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.02|0.84|
|[[:human_genes:A:ACYP1|ACYP1]]|-1.99|0.47|
|[[:human_genes:H:HCCS|HCCS]]|-1.98|0.70|
|[[:human_genes:N:NPTN|NPTN]]|-1.98|0.47|
|[[:human_genes:C:COQ9|COQ9]]|-1.97|0.47|
|[[:human_genes:Q:QARS|QARS]]|-1.96|0.87|
|[[:human_genes:L:LEO1|LEO1]]|-1.96|0.47|
|[[:human_genes:T:TSC2|TSC2]]|-1.95|0.47|
|[[:human_genes:C:CSAG1|CSAG1]]|-1.92|0.61|
|[[:human_genes:P:PTCD2|PTCD2]]|-1.89|0.57|
|[[:human_genes:O:OR10H3|OR10H3]]|-1.88|0.57|
|[[:human_genes:R:RBFOX1|RBFOX1]]|-1.87|0.69|
|[[:human_genes:C:CBX4|CBX4]]|-1.86|0.60|
|[[:human_genes:K:KRTAP5-4|KRTAP5-4]]|-1.85|0.84|
|[[:human_genes:P:PSMA1|PSMA1]]|1.90|0.82|
|[[:human_genes:T:TNFRSF12A|TNFRSF12A]]|1.90|0.62|
|[[:human_genes:R:RNPC3|RNPC3]]|1.90|0.72|
|[[:human_genes:A:APRT|APRT]]|1.92|0.82|
|[[:human_genes:S:SENP1|SENP1]]|1.92|0.72|
|[[:human_genes:C:CT62|CT62]]|1.92|0.59|
|[[:human_genes:R:RPS6KA6|RPS6KA6]]|2.00|0.42|
|[[:human_genes:P:PRPF19|PRPF19]]|2.02|0.82|
|[[:human_genes:Z:ZNF235|ZNF235]]|2.02|0.40|
|[[:human_genes:Z:ZNF737|ZNF737]]|2.03|0.59|
|[[:human_genes:U:UPF1|UPF1]]|2.03|0.72|
|[[:human_genes:P:PSMA5|PSMA5]]|2.10|0.82|
|[[:human_genes:S:SEC13|SEC13]]|2.13|0.82|
|[[:human_genes:C:CYP3A5|CYP3A5]]|2.13|0.28|
|[[:human_genes:N:NAA50|NAA50]]|2.15|0.28|
|[[:human_genes:R:RPS6KL1|RPS6KL1]]|2.18|0.35|
|[[:human_genes:H:HELT|HELT]]|2.18|0.35|
|[[:human_genes:Z:ZNF550|ZNF550]]|2.22|0.23|
|[[:human_genes:S:SCAP|SCAP]]|2.25|0.21|
|[[:human_genes:P:PSMD8|PSMD8]]|2.27|0.28|
|[[:human_genes:C:CLEC12B|CLEC12B]]|2.31|0.20|
|[[:human_genes:A:ATG10|ATG10]]|2.31|0.20|
|[[:human_genes:G:GOLGA6L6|GOLGA6L6]]|2.36|0.34|
|[[:human_genes:C:C1orf51|C1orf51]]|2.36|0.20|
|[[:human_genes:I:ISG20L2|ISG20L2]]|2.37|0.72|
|[[:human_genes:A:ADCK5|ADCK5]]|2.41|0.21|
|[[:human_genes:P:PCDH11X|PCDH11X]]|2.46|0.20|
|[[:human_genes:A:AMIGO1|AMIGO1]]|2.48|0.20|
|[[:human_genes:U:USP27X|USP27X]]|2.55|0.82|
|[[:human_genes:K:KCTD5|KCTD5]]|2.59|0.20|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>