Lead acetate 2000μM R08 exp498 no dilution day6 [The Human Chemical-Genetic Interaction Map Project]

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====== Lead acetate 2000μM R08 exp498 no dilution day6 ======
==== Mechanism of Action ====
Industrial pollutant, heavy metal toxin
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Heavy Metal




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Lead acetate trihydrate%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 6080-56-4
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/22456|22456]]
    * **<color #00a2e8>IUPAC:</color>** %%lead(2+);diacetate;trihydrate%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/2C2H4O2.3H2O.Pb/c2*1-2(3)4;;;;/h2*1H3,(H,3,4);3*1H2;/q;;;;;+2/p-2
    * **<color #00a2e8>INCHI Key:</color>** MCEUZMYFCCOOQO-UHFFFAOYSA-L
    * **<color #00a2e8>Molecular Weight:</color>** 379
    * **<color #00a2e8>Canonical SMILES:</color>** CC(=O)[O-].CC(=O)[O-].O.O.O.[Pb+2]
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C4H12O7Pb
{{:chemogenomics:structures:chem-0304.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** EM Science
    * **<color #00a2e8>Catalog #:</color>** LX0120-1
    * **<color #00a2e8>Lot #:</color>** 28147208
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>XRPD:</color>** Expected Pb(CH3COO)2 3H2O; found Pb(CH3COO)2 + 
Pb(CH3COO)2 3H2O
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Lead-Aceteate
    * **<color #00a2e8>Min:</color>** 2.9017; **<color #00a2e8>Max:</color>** 98.7157
{{:chemogenomics:dose_response:dr_435.png?nolink&500 |}}
\\ 
\\ 
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |1.3598    |
| IC30  |2.1266    |
| IC40  |3.0284    |
| IC50  |4.1663    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 2000µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.0
    * **<color #00a2e8>Numbers of reads</color>**: 16475946


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|21/63|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Lead_acetate_2000uM_Round-8_exp498.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Lead acetate 2000μM R08 exp498 no dilution day6'>
{{:chemogenomics:cranks_plots:exp498.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:T:TMEM165|TMEM165]]|-4.01|<0.01|
|[[:human_genes:B:BACH2|BACH2]]|-3.34|<0.01|
|[[:human_genes:Q:QRICH1|QRICH1]]|-3.12|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-3.00|<0.01|
|[[:human_genes:D:DDX47|DDX47]]|-2.95|0.08|
|[[:human_genes:U:UXS1|UXS1]]|-2.89|<0.01|
|[[:human_genes:F:FDFT1|FDFT1]]|-2.73|0.01|
|[[:human_genes:K:KEAP1|KEAP1]]|-2.72|0.03|
|[[:human_genes:K:KDSR|KDSR]]|-2.65|0.02|
|[[:human_genes:B:BCL11A|BCL11A]]|-2.63|0.02|
|[[:human_genes:A:ACBD3|ACBD3]]|-2.60|0.06|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.59|0.03|
|[[:human_genes:A:ATP1B4|ATP1B4]]|-2.53|0.05|
|[[:human_genes:E:ELAVL1|ELAVL1]]|-2.51|0.03|
|[[:human_genes:F:FDPS|FDPS]]|-2.50|0.05|
|[[:human_genes:A:ACTR10|ACTR10]]|-2.49|0.05|
|[[:human_genes:S:SOX4|SOX4]]|-2.48|0.09|
|[[:human_genes:S:SUPT7L|SUPT7L]]|-2.47|0.05|
|[[:human_genes:E:EP300|EP300]]|-2.45|0.15|
|[[:human_genes:T:TTC7A|TTC7A]]|-2.44|0.04|
|[[:human_genes:Z:ZNF770|ZNF770]]|-2.44|0.04|
|[[:human_genes:C:CNOT2|CNOT2]]|-2.41|0.05|
|[[:human_genes:P:PTDSS1|PTDSS1]]|-2.40|0.05|
|[[:human_genes:S:SIAH1|SIAH1]]|-2.36|0.05|
|[[:human_genes:Z:ZBTB10|ZBTB10]]|-2.34|0.05|
|[[:human_genes:R:RSRC2|RSRC2]]|-2.33|0.35|
|[[:human_genes:M:MTMR11|MTMR11]]|-2.31|0.05|
|[[:human_genes:S:SKA1|SKA1]]|-2.29|0.06|
|[[:human_genes:I:IGSF23|IGSF23]]|-2.27|0.10|
|[[:human_genes:L:LRRC16B|LRRC16B]]|-2.24|0.07|
|[[:human_genes:M:MAGT1|MAGT1]]|2.71|<0.01|
|[[:human_genes:S:STT3B|STT3B]]|2.74|<0.01|
|[[:human_genes:C:CXorf56|CXorf56]]|2.78|<0.01|
|[[:human_genes:P:PIH1D1|PIH1D1]]|2.83|<0.01|
|[[:human_genes:S:SAP130|SAP130]]|2.85|<0.01|
|[[:human_genes:A:AKT1|AKT1]]|2.86|<0.01|
|[[:human_genes:N:NF1|NF1]]|2.87|<0.01|
|[[:human_genes:E:EIF3F|EIF3F]]|2.90|<0.01|
|[[:human_genes:A:AKT2|AKT2]]|2.94|<0.01|
|[[:human_genes:A:AXIN1|AXIN1]]|2.99|<0.01|
|[[:human_genes:K:KCTD5|KCTD5]]|3.11|0.00|
|[[:human_genes:P:PRRC2C|PRRC2C]]|3.11|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|3.18|0.00|
|[[:human_genes:C:C12orf49|C12orf49]]|3.41|0.00|
|[[:human_genes:V:VPS37B|VPS37B]]|3.42|0.00|
|[[:human_genes:B:BRMS1|BRMS1]]|3.45|0.00|
|[[:human_genes:M:MEMO1|MEMO1]]|3.45|0.00|
|[[:human_genes:A:ARID4B|ARID4B]]|3.48|0.00|
|[[:human_genes:C:CTNNBIP1|CTNNBIP1]]|3.51|0.00|
|[[:human_genes:R:RICTOR|RICTOR]]|3.65|0.00|
|[[:human_genes:H:HEXIM1|HEXIM1]]|3.80|0.00|
|[[:human_genes:F:FBXO11|FBXO11]]|3.87|0.00|
|[[:human_genes:P:PPP6C|PPP6C]]|3.97|0.00|
|[[:human_genes:I:ING1|ING1]]|4.16|0.00|
|[[:human_genes:L:LZTR1|LZTR1]]|4.28|0.00|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|4.35|0.00|
|[[:human_genes:C:CMIP|CMIP]]|4.44|0.00|
|[[:human_genes:E:EIF4A1|EIF4A1]]|4.50|0.00|
|[[:human_genes:K:KMT2D|KMT2D]]|4.56|0.00|
|[[:human_genes:S:SCAP|SCAP]]|7.22|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|0.075|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.075|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.069|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.066|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.065|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.06|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.058|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.057|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.056|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|0.056|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|0.055|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.055|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.054|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|0.051|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.36|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.108|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.07|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.069|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|0.068|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.061|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.058|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.057|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.056|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.054|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.052|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|0.051|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|0.051|<button type="primary" size="small" modal="27">View</button>|
</modal>


<modal id="1" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Radicicol 0.16μM R05 exp242">
{{:chemogenomics:comparison_plots:exp242_vs_exp498.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Thapsigargin 0.005μM R07 exp407">
{{:chemogenomics:comparison_plots:exp407_vs_exp498.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp498_vs_exp525.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp498.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp498_vs_exp526.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp498_vs_exp502.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp498_vs_exp535.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp498_vs_exp517.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp498.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Rapamycin 10μM R00 exp30">
{{:chemogenomics:comparison_plots:exp30_vs_exp498.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  TRAIL 50ng/ml R00 exp36">
{{:chemogenomics:comparison_plots:exp36_vs_exp498.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp294_vs_exp498.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp498_vs_exp512.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Rucaparib 6.5μM R08 exp520">
{{:chemogenomics:comparison_plots:exp498_vs_exp520.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Lead acetate 2000μM R08 exp497  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp497_vs_exp498.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Ethanol 0.01 R05 exp234  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp234_vs_exp498.png?nolink |}}
</modal>

<modal id="17" size="lg" title="GSK626616 14μM R08 exp485  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp485_vs_exp498.png?nolink |}}
</modal>

<modal id="18" size="lg" title="B02 10μM R08 exp453  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp453_vs_exp498.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Calcium Ionophore 0.4μM R07 exp342  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp342_vs_exp498.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp489_vs_exp498.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Benzoate 20000μM R08 exp456  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp456_vs_exp498.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp488_vs_exp498.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Diepoxybutane 3μM R07 exp354  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp354_vs_exp498.png?nolink |}}
</modal>

<modal id="24" size="lg" title="AICAR 240μM R03 exp116  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp116_vs_exp498.png?nolink |}}
</modal>

<modal id="25" size="lg" title="FK-506 30μM R07 exp359  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp359_vs_exp498.png?nolink |}}
</modal>

<modal id="26" size="lg" title="I-BRD9 4μM R07 exp365  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp365_vs_exp498.png?nolink |}}
</modal>

<modal id="27" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp334_vs_exp498.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|negative regulation of long-chain fatty acid import into cell|368.20|AKT2,AKT1|
|negative regulation of long-chain fatty acid import across plasma membrane|368.20|AKT2,AKT1|
|Sin3-type complex|105.20|ING1,ARID4B,BRMS1,SAP130|
|Sin3 complex|105.20|ING1,ARID4B,BRMS1,SAP130|
|negative regulation of stem cell population maintenance|92.05|ING1,ARID4B,BRMS1,SAP130|
|myelination in peripheral nervous system|63.73|AKT2,NF1,AKT1|
|peripheral nervous system axon ensheathment|63.73|AKT2,NF1,AKT1|
|Schwann cell development|57.13|AKT2,NF1,AKT1|
|positive regulation of stem cell population maintenance|47.00|ING1,ARID4B,BRMS1,SAP130|
|regulation of stem cell population maintenance|31.56|ING1,ARID4B,BRMS1,SAP130|
|histone deacetylase complex|27.62|ING1,ARID4B,BRMS1,SAP130|
|negative regulation of transforming growth factor beta receptor signaling pathway|24.55|ING1,ARID4B,BRMS1,SAP130|
|regulation of peptidyl-serine phosphorylation|21.08|MAPKAP1,RICTOR,BAK1,AXIN1,AKT1|
|regulation of transforming growth factor beta receptor signaling pathway|20.31|ING1,ARID4B,BRMS1,AXIN1,SAP130|
|regulation of cellular response to transforming growth factor beta stimulus|19.87|ING1,ARID4B,BRMS1,AXIN1,SAP130|
|negative regulation of cell migration|11.96|ING1,ARID4B,BRMS1,NF1,AKT1,SAP130|
|negative regulation of cell motility|11.35|ING1,ARID4B,BRMS1,NF1,AKT1,SAP130|
|negative regulation of locomotion|10.13|ING1,ARID4B,BRMS1,NF1,AKT1,SAP130|
|regulation of protein phosphorylation|6.63|MAPKAP1,HEXIM1,RICTOR,BAK1,AXIN1,AKT2,NF1,AKT1,PIH1D1,EIF2AK3,PHIP|
</modal>