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Ask your administrator if you think this is wrong. ====== LY2090314 0.003μM R08 exp500 no dilution day6 ====== ==== Mechanism of Action ==== Inhibits glycogen synthase kinase-3 (GSK-3), activates Wnt signalling * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Kinase Inhibitor ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%3-[6-Fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione%% * **<color #00a2e8>Synonyms:</color>** N/A * **<color #00a2e8>CAS #:</color>** 603288-22-8 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/10029385|10029385]] * **<color #00a2e8>IUPAC:</color>** %%3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37) * **<color #00a2e8>INCHI Key:</color>** HRJWTAWVFDCTGO-UHFFFAOYSA-N * **<color #00a2e8>Molecular Weight:</color>** 512.5 * **<color #00a2e8>Canonical SMILES:</color>** C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7 * **<color #00a2e8>Isomeric SMILES:</color>** N/A * **<color #00a2e8>Molecular Formula:</color>** C28H25FN6O3 {{:chemogenomics:structures:chem-0305.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** Med Chem Express * **<color #00a2e8>Catalog #:</color>** HY-16294 * **<color #00a2e8>Lot #:</color>** 11009 </panel> <panel title='Compound Characterization' collapsed='true'> * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C28H25FN6O3 513.20449; found 513.208 </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** LY2090314 * **<color #00a2e8>Min:</color>** -16.6945; **<color #00a2e8>Max:</color>** 87.6124 {{:chemogenomics:dose_response:dr_614.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |0.0026 | | IC20 |0.0033 | | IC30 |0.0039 | | IC40 |0.0044 | | IC50 |0.0050 | | IC60 |0.0056 | | IC70 |0.0064 | | IC80 |0.0076 | | IC90 |0.0096 | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 08 * **<color #00a2e8>Dose</color>**: 3nM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: 3.6 * **<color #00a2e8>Numbers of reads</color>**: 15503499 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |46/75|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/LY2090314_0.003uM_Round-8_exp500.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='LY2090314 0.003μM R08 exp500 no dilution day6'> {{:chemogenomics:cranks_plots:exp500.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:G:GSK3B|GSK3B]]|-5.52|0.00| |[[:human_genes:N:NPRL3|NPRL3]]|-4.93|0.00| |[[:human_genes:N:NPRL2|NPRL2]]|-4.14|0.00| |[[:human_genes:S:SZT2|SZT2]]|-4.05|0.00| |[[:human_genes:R:RING1|RING1]]|-3.57|0.00| |[[:human_genes:M:MSI2|MSI2]]|-3.57|0.00| |[[:human_genes:T:TCF4|TCF4]]|-3.54|0.00| |[[:human_genes:I:ITFG2|ITFG2]]|-3.47|0.00| |[[:human_genes:C:C12orf66|C12orf66]]|-3.41|0.00| |[[:human_genes:Z:ZBTB24|ZBTB24]]|-3.41|0.00| |[[:human_genes:M:MAPRE1|MAPRE1]]|-3.23|<0.01| |[[:human_genes:P:PCBP2|PCBP2]]|-3.23|0.00| |[[:human_genes:I:IVNS1ABP|IVNS1ABP]]|-3.13|0.00| |[[:human_genes:D:DEPDC5|DEPDC5]]|-3.11|<0.01| |[[:human_genes:P:PRKAA1|PRKAA1]]|-3.00|<0.01| |[[:human_genes:I:ILF3|ILF3]]|-2.97|0.04| |[[:human_genes:P:PRMT7|PRMT7]]|-2.97|<0.01| |[[:human_genes:B:BACH2|BACH2]]|-2.86|<0.01| |[[:human_genes:C:CSTB|CSTB]]|-2.86|<0.01| |[[:human_genes:P:PRKCE|PRKCE]]|-2.84|<0.01| |[[:human_genes:O:OTUB1|OTUB1]]|-2.84|<0.01| |[[:human_genes:B:BCL6|BCL6]]|-2.82|<0.01| |[[:human_genes:I:INTS12|INTS12]]|-2.72|<0.01| |[[:human_genes:P:PRPS1|PRPS1]]|-2.70|<0.01| |[[:human_genes:F:FLI1|FLI1]]|-2.67|<0.01| |[[:human_genes:A:AXIN1|AXIN1]]|-2.66|0.01| |[[:human_genes:E:ELAVL1|ELAVL1]]|-2.64|<0.01| |[[:human_genes:U:UXS1|UXS1]]|-2.62|<0.01| |[[:human_genes:C:CCDC130|CCDC130]]|-2.60|<0.01| |[[:human_genes:U:UBE4B|UBE4B]]|-2.56|<0.01| |[[:human_genes:A:ALDH18A1|ALDH18A1]]|2.79|<0.01| |[[:human_genes:H:HDAC1|HDAC1]]|2.79|<0.01| |[[:human_genes:M:MAPKAP1|MAPKAP1]]|2.87|<0.01| |[[:human_genes:P:PPP3CA|PPP3CA]]|2.88|<0.01| |[[:human_genes:T:TRIP12|TRIP12]]|2.89|<0.01| |[[:human_genes:I:INO80C|INO80C]]|2.89|<0.01| |[[:human_genes:S:SLC12A2|SLC12A2]]|2.91|<0.01| |[[:human_genes:B:BAP1|BAP1]]|2.91|<0.01| |[[:human_genes:T:TIAL1|TIAL1]]|2.96|<0.01| |[[:human_genes:D:DYRK1A|DYRK1A]]|2.99|0.00| |[[:human_genes:L:LDB1|LDB1]]|3.11|0.00| |[[:human_genes:P:PDS5A|PDS5A]]|3.27|0.00| |[[:human_genes:I:ING1|ING1]]|3.38|0.00| |[[:human_genes:R:RB1|RB1]]|3.42|0.00| |[[:human_genes:F:FOXK1|FOXK1]]|3.70|0.00| |[[:human_genes:S:SRM|SRM]]|3.72|0.00| |[[:human_genes:N:NFRKB|NFRKB]]|3.85|0.00| |[[:human_genes:T:TNKS2|TNKS2]]|4.14|0.00| |[[:human_genes:A:ATP2B1|ATP2B1]]|4.17|0.00| |[[:human_genes:M:MLST8|MLST8]]|4.32|0.00| |[[:human_genes:A:ARID1A|ARID1A]]|4.33|0.00| |[[:human_genes:N:NSD1|NSD1]]|4.64|0.00| |[[:human_genes:K:KLF16|KLF16]]|4.64|0.00| |[[:human_genes:R:RPTOR|RPTOR]]|4.67|0.00| |[[:human_genes:D:DOHH|DOHH]]|4.77|0.00| |[[:human_genes:M:MBNL1|MBNL1]]|5.49|0.00| |[[:human_genes:I:ID3|ID3]]|5.99|0.00| |[[:human_genes:J:JUP|JUP]]|7.01|0.00| |[[:human_genes:L:LEF1|LEF1]]|7.36|0.00| |[[:human_genes:C:CTNNB1|CTNNB1]]|7.43|0.00| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.09|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp517|Quercetin 20μM R08 exp517]]|0.068|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.067|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp502|Milciclib 2μM R08 exp502]]|0.064|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp59|UMK57 1μM R01 exp59]]|0.06|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.057|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp242|Radicicol 0.16μM R05 exp242]]|0.057|<button type="primary" size="small" modal="7">View</button>| |[[:results:exp103|Taxol 0.004μM R03 exp103]]|0.056|<button type="primary" size="small" modal="8">View</button>| |[[:results:exp134|MS023 2μM R03 exp134]]|0.054|<button type="primary" size="small" modal="9">View</button>| |[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.054|<button type="primary" size="small" modal="10">View</button>| |[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.053|<button type="primary" size="small" modal="11">View</button>| |[[:results:exp135|MS023 7μM R03 exp135]]|0.053|<button type="primary" size="small" modal="12">View</button>| |[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.053|<button type="primary" size="small" modal="13">View</button>| |[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.052|<button type="primary" size="small" modal="14">View</button>| |[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|0.052|<button type="primary" size="small" modal="15">View</button>| |[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.052|<button type="primary" size="small" modal="16">View</button>| |[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.052|<button type="primary" size="small" modal="17">View</button>| |[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.448|<button type="primary" size="small" modal="18">View</button>| |[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|0.081|<button type="primary" size="small" modal="19">View</button>| |[[:results:exp67|BVD-523 15μM R02 exp67]]|0.078|<button type="primary" size="small" modal="20">View</button>| |[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.074|<button type="primary" size="small" modal="21">View</button>| |[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.068|<button type="primary" size="small" modal="22">View</button>| |[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.062|<button type="primary" size="small" modal="23">View</button>| |[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.061|<button type="primary" size="small" modal="24">View</button>| |[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.061|<button type="primary" size="small" modal="25">View</button>| |[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.059|<button type="primary" size="small" modal="26">View</button>| |[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.059|<button type="primary" size="small" modal="27">View</button>| |[[:results:exp211|AICAR 240μM R05 exp211]]|0.057|<button type="primary" size="small" modal="28">View</button>| |[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|0.056|<button type="primary" size="small" modal="29">View</button>| |[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|0.056|<button type="primary" size="small" modal="30">View</button>| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.055|<button type="primary" size="small" modal="31">View</button>| |[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.055|<button type="primary" size="small" modal="32">View</button>| |[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.054|<button type="primary" size="small" modal="33">View</button>| |[[:results:exp365|I-BRD9 4μM R07 exp365]]|0.053|<button type="primary" size="small" modal="34">View</button>| |[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.053|<button type="primary" size="small" modal="35">View</button>| |[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.052|<button type="primary" size="small" modal="36">View</button>| |[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.051|<button type="primary" size="small" modal="37">View</button>| </modal> <modal id="1" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs MLN-4924 0.2μM R00 exp21"> {{:chemogenomics:comparison_plots:exp21_vs_exp500.png?nolink |}} </modal> <modal id="2" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs Quercetin 20μM R08 exp517"> {{:chemogenomics:comparison_plots:exp500_vs_exp517.png?nolink |}} </modal> <modal id="3" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs UM131593 0.2μM R03 exp106"> {{:chemogenomics:comparison_plots:exp106_vs_exp500.png?nolink |}} </modal> <modal id="4" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs Milciclib 2μM R08 exp502"> {{:chemogenomics:comparison_plots:exp500_vs_exp502.png?nolink |}} </modal> <modal id="5" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs UMK57 1μM R01 exp59"> {{:chemogenomics:comparison_plots:exp500_vs_exp59.png?nolink |}} </modal> <modal id="6" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs THZ1 0.06μM R08 exp531"> {{:chemogenomics:comparison_plots:exp500_vs_exp531.png?nolink |}} </modal> <modal id="7" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs Radicicol 0.16μM R05 exp242"> {{:chemogenomics:comparison_plots:exp242_vs_exp500.png?nolink |}} </modal> <modal id="8" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs Taxol 0.004μM R03 exp103"> {{:chemogenomics:comparison_plots:exp103_vs_exp500.png?nolink |}} </modal> <modal id="9" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs MS023 2μM R03 exp134"> {{:chemogenomics:comparison_plots:exp134_vs_exp500.png?nolink |}} </modal> <modal id="10" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs RO-3307 4.7μM R02 exp80"> {{:chemogenomics:comparison_plots:exp500_vs_exp80.png?nolink |}} </modal> <modal id="11" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs UM0125461 0.74μM R02 exp84"> {{:chemogenomics:comparison_plots:exp500_vs_exp84.png?nolink |}} </modal> <modal id="12" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs MS023 7μM R03 exp135"> {{:chemogenomics:comparison_plots:exp135_vs_exp500.png?nolink |}} </modal> <modal id="13" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs Sulforaphane 9μM R08 exp526 no dilution day6"> {{:chemogenomics:comparison_plots:exp500_vs_exp526.png?nolink |}} </modal> <modal id="14" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs ML-792 0.2μM R08 exp505"> {{:chemogenomics:comparison_plots:exp500_vs_exp505.png?nolink |}} </modal> <modal id="15" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs TRAIL 5ng/ml R00 exp35"> {{:chemogenomics:comparison_plots:exp35_vs_exp500.png?nolink |}} </modal> <modal id="16" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs Sulforaphane 9μM R08 exp525"> {{:chemogenomics:comparison_plots:exp500_vs_exp525.png?nolink |}} </modal> <modal id="17" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6 vs Lead acetate 2000μM R08 exp497"> {{:chemogenomics:comparison_plots:exp497_vs_exp500.png?nolink |}} </modal> <modal id="18" size="lg" title="LY2090314 0.003μM R08 exp499 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp499_vs_exp500.png?nolink |}} </modal> <modal id="19" size="lg" title="3-Bromopyruvate 7μM R04 exp175 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp175_vs_exp500.png?nolink |}} </modal> <modal id="20" size="lg" title="BVD-523 15μM R02 exp67 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp500_vs_exp67.png?nolink |}} </modal> <modal id="21" size="lg" title="Aphidicolin 0.4μM R08 exp440 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp440_vs_exp500.png?nolink |}} </modal> <modal id="22" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp489_vs_exp500.png?nolink |}} </modal> <modal id="23" size="lg" title="JQ1 0.8μM R08 exp435 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp435_vs_exp500.png?nolink |}} </modal> <modal id="24" size="lg" title="CB-5083 0.4μM R08 exp468 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp468_vs_exp500.png?nolink |}} </modal> <modal id="25" size="lg" title="Ethanol 0.01 R05 exp234 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp234_vs_exp500.png?nolink |}} </modal> <modal id="26" size="lg" title="Benzoate 20000μM R08 exp456 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp456_vs_exp500.png?nolink |}} </modal> <modal id="27" size="lg" title="Artemisinin 50μM R08 exp450 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp450_vs_exp500.png?nolink |}} </modal> <modal id="28" size="lg" title="AICAR 240μM R05 exp211 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp211_vs_exp500.png?nolink |}} </modal> <modal id="29" size="lg" title="Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp179_vs_exp500.png?nolink |}} </modal> <modal id="30" size="lg" title="Epothilone-B 0.0015μM R05 exp231 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp231_vs_exp500.png?nolink |}} </modal> <modal id="31" size="lg" title="5-Fluorouracil 20μM R00 exp2 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp2_vs_exp500.png?nolink |}} </modal> <modal id="32" size="lg" title="Hippuristanol 0.12μM R08 exp488 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp488_vs_exp500.png?nolink |}} </modal> <modal id="33" size="lg" title="Atovaquone 15μM R08 exp451 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp451_vs_exp500.png?nolink |}} </modal> <modal id="34" size="lg" title="I-BRD9 4μM R07 exp365 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp365_vs_exp500.png?nolink |}} </modal> <modal id="35" size="lg" title="BML-284 0.09μM R08 exp460 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp460_vs_exp500.png?nolink |}} </modal> <modal id="36" size="lg" title="Bleomycin 5μM R08 exp459 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp459_vs_exp500.png?nolink |}} </modal> <modal id="37" size="lg" title="Actinomycin-D 0.001μM R00 exp3 vs LY2090314 0.003μM R08 exp500 no dilution day6"> {{:chemogenomics:comparison_plots:exp3_vs_exp500.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms"> ^GO Term^Fold Change^Genes^ |GATOR1 complex|613.67|NPRL3,NPRL2| |Seh1-associated complex|263.00|NPRL3,NPRL2,DEPDC5| |negative regulation of TORC1 signaling|89.80|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1| |cellular response to amino acid starvation|63.92|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5| |response to amino acid starvation|60.16|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5| |negative regulation of TOR signaling|55.79|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1| |regulation of TORC1 signaling|49.95|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1,OTUB1| |regulation of TOR signaling|27.27|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1| |cellular response to starvation|21.53|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1| |positive regulation of autophagy|21.02|GSK3B,NPRL3,NPRL2,DEPDC5,PRKAA1| |response to starvation|17.53|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1| |cellular response to nutrient levels|15.80|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1| |cellular response to extracellular stimulus|14.05|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1| |cellular response to external stimulus|11.26|NPRL3,NPRL2,SZT2,ITFG2,DEPDC5,PRKAA1| |negative regulation of intracellular signal transduction|10.79|GSK3B,NPRL3,NPRL2,SZT2,ITFG2,IVNS1ABP,DEPDC5,PRKAA1,BCL6| |positive regulation of catabolic process|8.34|GSK3B,NPRL3,NPRL2,DEPDC5,PRKAA1,PRKCE,AXIN1| </modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms"> ^GO Term^Fold Change^Genes^ |positive regulation of pentose-phosphate shunt|552.30|RPTOR,MLST8| |beta-catenin-TCF complex|138.08|CTNNB1,LEF1,LDB1| |tongue development|87.21|CTNNB1,LEF1,HDAC1| |positive regulation of myeloid leukocyte differentiation|38.76|LEF1,RPTOR,RB1,PPP3CA| |SWI/SNF superfamily-type complex|37.23|ARID1A,NFRKB,RB1,INO80C,GATAD2A,HDAC1| |ATPase complex|23.84|ARID1A,NFRKB,RB1,INO80C,GATAD2A,HDAC1| |regulation of myeloid leukocyte differentiation|23.40|CTNNB1,LEF1,RPTOR,RB1,PPP3CA| |nuclear receptor binding|20.61|CTNNB1,LEF1,NSD1,ARID1A,TRIP12| |regulation of myeloid cell differentiation|17.63|CTNNB1,LEF1,RPTOR,RB1,LDB1,PPP3CA| |regulation of chromosome organization|13.69|CTNNB1,ARID1A,TNKS2,NFRKB,RB1,INO80C| |RNA polymerase II-specific DNA-binding transcription factor binding|13.03|CTNNB1,LEF1,NSD1,ARID1A,RB1,LDB1,TRIP12,HDAC1| |DNA-binding transcription factor binding|11.78|CTNNB1,LEF1,JUP,ID3,NSD1,ARID1A,RB1,LDB1,TRIP12,HDAC1| |transcription factor binding|10.33|CTNNB1,LEF1,JUP,ID3,RPTOR,NSD1,ARID1A,RB1,LDB1,TRIP12,HDAC1| |regulation of hemopoiesis|9.94|CTNNB1,LEF1,RPTOR,ARID1A,RB1,LDB1,PPP3CA| |chromatin remodeling|9.81|NSD1,ARID1A,NFRKB,RB1,DYRK1A,BAP1,INO80C,TRIP12,GATAD2A,HDAC1| |transcription coregulator activity|9.07|CTNNB1,JUP,NSD1,ARID1A,RB1,LDB1,DYRK1A,HDAC1| |chromatin organization|7.83|NSD1,ARID1A,NFRKB,RB1,DYRK1A,BAP1,INO80C,TRIP12,GATAD2A,HDAC1| |protein-DNA complex organization|7.05|NSD1,ARID1A,NFRKB,RB1,DYRK1A,BAP1,INO80C,TRIP12,GATAD2A,HDAC1| |negative regulation of transcription by RNA polymerase II|6.32|CTNNB1,LEF1,ID3,KLF16,NSD1,FOXK1,RB1,ING1,LDB1,GATAD2A,HDAC1| </modal> Last modified: 2026/01/15 21:36by 127.0.0.1