RK-33 8μM R08 exp518 [The Human Chemical-Genetic Interaction Map Project]

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====== RK-33 8μM R08 exp518 ======
==== Mechanism of Action ====
Inhibits DDX3 RNA helicase, causes G1 arrest and apoptosis, broad spectrum anti-viral
  * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / Translation Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Infectious Disease / Antiviral



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%5,11-Bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1070773-09-9
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/46184988|46184988]]
    * **<color #00a2e8>IUPAC:</color>** %%5,11-bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C23H20N6O3/c1-31-17-7-3-15(4-8-17)11-28-14-26-19-20-22(25-13-24-21(19)28)29(23(30)27-20)12-16-5-9-18(32-2)10-6-16/h3-10,13-14H,11-12H2,1-2H3
    * **<color #00a2e8>INCHI Key:</color>** COUMZXFUZDBRCZ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 428.4
    * **<color #00a2e8>Canonical SMILES:</color>** COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C23H20N6O3
{{:chemogenomics:structures:chem-0323.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-100455
    * **<color #00a2e8>Lot #:</color>** 21870
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C23H20N6O3 429.16697; found 429.16419
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** RK33
    * **<color #00a2e8>Min:</color>** -5.9360; **<color #00a2e8>Max:</color>** 99.1047
{{:chemogenomics:dose_response:dr_575.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |4.0260    |
| IC20  |5.9440    |
| IC30  |7.7020    |
| IC40  |9.5230    |
| IC50  |11.5700    |
| IC60  |14.0600    |
| IC70  |17.3900    |
| IC80  |22.5300    |
| IC90  |33.2600    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 8µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: -0.0
    * **<color #00a2e8>Numbers of reads</color>**: 17248474


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/16|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/RK-33_8uM_Round-8_exp518.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='RK-33 8μM R08 exp518'>
{{:chemogenomics:cranks_plots:exp518.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ATP6AP1|ATP6AP1]]|-2.97|0.48|
|[[:human_genes:T:TCF3|TCF3]]|-2.94|0.21|
|[[:human_genes:M:MARVELD1|MARVELD1]]|-2.92|0.70|
|[[:human_genes:U:UBE2N|UBE2N]]|-2.44|0.27|
|[[:human_genes:S:SLC10A7|SLC10A7]]|-2.30|0.27|
|[[:human_genes:P:PTPRN2|PTPRN2]]|-2.29|0.27|
|[[:human_genes:C:CNPY2|CNPY2]]|-2.29|0.27|
|[[:human_genes:D:DNA2|DNA2]]|-2.25|0.70|
|[[:human_genes:R:RPS28|RPS28]]|-2.22|0.73|
|[[:human_genes:C:CYB561A3|CYB561A3]]|-2.22|0.56|
|[[:human_genes:P:PSMD7|PSMD7]]|-2.21|0.73|
|[[:human_genes:I:ING1|ING1]]|-2.21|0.36|
|[[:human_genes:G:GLE1|GLE1]]|-2.17|0.73|
|[[:human_genes:N:NOL11|NOL11]]|-2.16|0.48|
|[[:human_genes:P:PABPC3|PABPC3]]|-2.16|0.41|
|[[:human_genes:P:PSAP|PSAP]]|-2.14|0.48|
|[[:human_genes:A:ATP6V0B|ATP6V0B]]|-2.12|0.75|
|[[:human_genes:R:RUFY3|RUFY3]]|-2.09|0.48|
|[[:human_genes:C:COPE|COPE]]|-2.09|0.75|
|[[:human_genes:A:AHCTF1|AHCTF1]]|-2.09|0.55|
|[[:human_genes:T:TPX2|TPX2]]|-2.06|0.56|
|[[:human_genes:L:LTBR|LTBR]]|-2.04|0.48|
|[[:human_genes:I:IFNAR2|IFNAR2]]|-2.01|0.48|
|[[:human_genes:M:MDM4|MDM4]]|-2.01|0.48|
|[[:human_genes:F:FAM9B|FAM9B]]|-1.96|0.70|
|[[:human_genes:K:KIF23|KIF23]]|-1.96|0.70|
|[[:human_genes:T:THY1|THY1]]|-1.95|0.70|
|[[:human_genes:C:CENPM|CENPM]]|-1.94|0.75|
|[[:human_genes:S:SOCS2|SOCS2]]|-1.90|0.64|
|[[:human_genes:S:SETBP1|SETBP1]]|-1.90|0.64|
|[[:human_genes:T:TAS2R5|TAS2R5]]|2.05|0.31|
|[[:human_genes:G:GART|GART]]|2.05|0.66|
|[[:human_genes:G:GFRAL|GFRAL]]|2.07|0.20|
|[[:human_genes:U:UGDH|UGDH]]|2.10|0.18|
|[[:human_genes:S:SLC7A1|SLC7A1]]|2.13|0.41|
|[[:human_genes:N:NOSIP|NOSIP]]|2.14|0.24|
|[[:human_genes:S:STARD7|STARD7]]|2.20|0.20|
|[[:human_genes:S:SOX12|SOX12]]|2.20|0.36|
|[[:human_genes:O:OBSL1|OBSL1]]|2.21|0.31|
|[[:human_genes:C:CAPRIN1|CAPRIN1]]|2.29|0.07|
|[[:human_genes:S:SYK|SYK]]|2.29|0.07|
|[[:human_genes:R:RFK|RFK]]|2.36|0.05|
|[[:human_genes:B:BRD2|BRD2]]|2.37|0.09|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|2.39|0.08|
|[[:human_genes:J:JUN|JUN]]|2.41|0.04|
|[[:human_genes:P:PRKACA|PRKACA]]|2.44|0.04|
|[[:human_genes:T:TMEM30A|TMEM30A]]|2.46|0.03|
|[[:human_genes:E:ELF1|ELF1]]|2.65|0.02|
|[[:human_genes:E:EPT1|EPT1]]|2.67|0.03|
|[[:human_genes:A:ACSL4|ACSL4]]|2.73|0.02|
|[[:human_genes:A:ACLY|ACLY]]|2.81|0.02|
|[[:human_genes:A:ATXN2L|ATXN2L]]|2.86|0.01|
|[[:human_genes:P:PNPLA2|PNPLA2]]|2.88|<0.01|
|[[:human_genes:P:PGRMC2|PGRMC2]]|2.91|0.01|
|[[:human_genes:G:GCLC|GCLC]]|3.95|<0.01|
|[[:human_genes:G:GSS|GSS]]|4.29|<0.01|
|[[:human_genes:A:AGPAT1|AGPAT1]]|5.29|<0.01|
|[[:human_genes:O:OSGIN2|OSGIN2]]|7.59|<0.01|
|[[:human_genes:G:GCLM|GCLM]]|8.49|<0.01|
|[[:human_genes:G:GSTO1|GSTO1]]|8.50|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|JAK pathway signal transduction adaptor activity|571.34|IFNAR2,SOCS2|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|response to human chorionic gonadotropin|276.15|GCLM,GCLC|
|nonribosomal peptide biosynthetic process|118.35|GCLM,GSS,GCLC|
|acid-amino acid ligase activity|78.90|GCLM,GSS,GCLC|
|ligase activity, forming carbon-nitrogen bonds|47.00|GCLM,GSS,GCLC,GART|
|glutathione metabolic process|42.48|GSTO1,GCLM,GSS,GCLC|
|ligase activity|17.59|GCLM,GSS,GCLC,ACSL4,GART|
|carboxylic acid metabolic process|6.17|GSTO1,GCLM,GSS,GCLC,ACLY,ACSL4,SYK,UGDH,GART|
|oxoacid metabolic process|6.01|GSTO1,GCLM,GSS,GCLC,ACLY,ACSL4,SYK,UGDH,GART|
|organic acid metabolic process|5.96|GSTO1,GCLM,GSS,GCLC,ACLY,ACSL4,SYK,UGDH,GART|
</modal>