Salinomycin 3.5μM R08 exp521 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
====== Salinomycin 3.5μM R08 exp521 ======
==== Mechanism of Action ====
Potassium ionophore antibiotic, has activity against cancer stem cells
  * **<color #00a2e8>Class / Subclass 1:</color>** Organelle Function / Membrane Ionophore




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Salinomycin%%
    * **<color #00a2e8>Synonyms:</color>** Procoxacin
    * **<color #00a2e8>CAS #:</color>** 53003-10-4
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/3085092|3085092]]
    * **<color #00a2e8>IUPAC:</color>** %%(2R)-2-[(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** KQXDHUJYNAXLNZ-XQSDOZFQSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 751
    * **<color #00a2e8>Canonical SMILES:</color>** CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** CC[C@H]([C@H]1CC[C@@H]([C@@H](O1)[C@@H](C)[C@@H]([C@H](C)C(=O)[C@H](CC)[C@@H]2[C@H](C[C@H]([C@]3(O2)C=C[C@H]([C@@]4(O3)CC[C@@](O4)(C)[C@H]5CC[C@@]([C@@H](O5)C)(CC)O)O)C)C)O)C)C(=O)O
    * **<color #00a2e8>Molecular Formula:</color>** C42H70O11
{{:chemogenomics:structures:chem-0326.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-15597
    * **<color #00a2e8>Lot #:</color>** 29177
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C42H70O11 773.48103; found 773.48272
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Salinomycin
    * **<color #00a2e8>Min:</color>** -0.8817; **<color #00a2e8>Max:</color>** 94.0110
{{:chemogenomics:dose_response:dr_579.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.1966    |
| IC20  |0.5768    |
| IC30  |1.1790    |
| IC40  |2.1200    |
| IC50  |3.6320    |
| IC60  |6.2210    |
| IC70  |11.1800    |
| IC80  |22.8700    |
| IC90  |67.0900    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 3.5µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.1
    * **<color #00a2e8>Numbers of reads</color>**: 19105923


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Salinomycin_3.5uM_Round-8_exp521.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Salinomycin 3.5μM R08 exp521'>
{{:chemogenomics:cranks_plots:exp521.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SMC2|SMC2]]|-2.94|0.38|
|[[:human_genes:U:UBAP1|UBAP1]]|-2.88|0.06|
|[[:human_genes:T:TOP1MT|TOP1MT]]|-2.87|0.04|
|[[:human_genes:C:COPE|COPE]]|-2.58|0.51|
|[[:human_genes:G:GK2|GK2]]|-2.51|0.12|
|[[:human_genes:M:MS4A13|MS4A13]]|-2.42|0.63|
|[[:human_genes:H:HMGCR|HMGCR]]|-2.38|0.51|
|[[:human_genes:P:PSMA1|PSMA1]]|-2.24|0.51|
|[[:human_genes:P:PRRT3|PRRT3]]|-2.21|0.38|
|[[:human_genes:F:FLG2|FLG2]]|-2.17|0.38|
|[[:human_genes:T:TFIP11|TFIP11]]|-2.15|0.38|
|[[:human_genes:P:PPP2R5D|PPP2R5D]]|-2.14|0.38|
|[[:human_genes:C:C16orf11|C16orf11]]|-2.13|0.38|
|[[:human_genes:C:CEBPA|CEBPA]]|-2.13|0.45|
|[[:human_genes:I:ITGB7|ITGB7]]|-2.11|0.45|
|[[:human_genes:P:POLA1|POLA1]]|-2.10|0.57|
|[[:human_genes:L:LOC100505679|LOC100505679]]|-2.08|0.65|
|[[:human_genes:R:RPL18|RPL18]]|-2.08|0.68|
|[[:human_genes:P:PLK1|PLK1]]|-2.07|0.65|
|[[:human_genes:P:PRPF4|PRPF4]]|-2.06|0.51|
|[[:human_genes:K:KANSL2|KANSL2]]|-2.06|0.45|
|[[:human_genes:P:PRPF31|PRPF31]]|-2.05|0.56|
|[[:human_genes:N:NRDE2|NRDE2]]|-2.04|0.51|
|[[:human_genes:R:RPS18|RPS18]]|-2.03|0.45|
|[[:human_genes:C:CCDC94|CCDC94]]|-2.03|0.58|
|[[:human_genes:P:PSMD6|PSMD6]]|-2.03|0.58|
|[[:human_genes:G:GPR101|GPR101]]|-2.03|0.45|
|[[:human_genes:B:BIRC5|BIRC5]]|-2.02|0.51|
|[[:human_genes:P:PRR22|PRR22]]|-2.02|0.45|
|[[:human_genes:I:IFNLR1|IFNLR1]]|-2.01|0.45|
|[[:human_genes:K:KRTAP5-9|KRTAP5-9]]|2.06|0.27|
|[[:human_genes:T:TXNDC11|TXNDC11]]|2.06|0.36|
|[[:human_genes:T:TRAPPC9|TRAPPC9]]|2.07|0.27|
|[[:human_genes:Z:ZRSR2|ZRSR2]]|2.08|0.27|
|[[:human_genes:S:SRPRB|SRPRB]]|2.09|0.27|
|[[:human_genes:C:C6orf203|C6orf203]]|2.10|0.27|
|[[:human_genes:C:CHKA|CHKA]]|2.11|0.27|
|[[:human_genes:T:TEKT5|TEKT5]]|2.11|0.27|
|[[:human_genes:F:FASTKD5|FASTKD5]]|2.12|0.29|
|[[:human_genes:W:WDR77|WDR77]]|2.13|0.34|
|[[:human_genes:E:ELSPBP1|ELSPBP1]]|2.13|0.28|
|[[:human_genes:R:RPE|RPE]]|2.13|0.28|
|[[:human_genes:U:UHRF1|UHRF1]]|2.16|0.34|
|[[:human_genes:P:PHIP|PHIP]]|2.19|0.23|
|[[:human_genes:T:TAF5L|TAF5L]]|2.19|0.27|
|[[:human_genes:M:MRPS28|MRPS28]]|2.22|0.22|
|[[:human_genes:D:DNAJC11|DNAJC11]]|2.23|0.31|
|[[:human_genes:E:ENO1|ENO1]]|2.23|0.36|
|[[:human_genes:S:SOX7|SOX7]]|2.24|0.22|
|[[:human_genes:E:EIF4G2|EIF4G2]]|2.26|0.22|
|[[:human_genes:W:WDR82|WDR82]]|2.28|0.34|
|[[:human_genes:I:IGBP1|IGBP1]]|2.30|0.34|
|[[:human_genes:G:GFM2|GFM2]]|2.35|0.22|
|[[:human_genes:U:USMG5|USMG5]]|2.37|0.53|
|[[:human_genes:Z:ZNF259|ZNF259]]|2.40|0.22|
|[[:human_genes:M:MRPS6|MRPS6]]|2.45|0.22|
|[[:human_genes:D:DARS2|DARS2]]|2.46|0.34|
|[[:human_genes:R:ROCK2|ROCK2]]|2.61|0.22|
|[[:human_genes:G:GEMIN7|GEMIN7]]|2.77|0.06|
|[[:human_genes:G:GMPPB|GMPPB]]|3.35|0.22|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>