TGF-beta1 44ng/ml R08 exp528 [The Human Chemical-Genetic Interaction Map Project]

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====== TGF-beta1 44ng/ml R08 exp528 ======
==== Mechanism of Action ====
Ligand for TGF-β1 receptor
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Other Receptor Agonist




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 25kDa
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK
{{:chemogenomics:structures:chem-0332.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** PeproTech
    * **<color #00a2e8>Catalog #:</color>** 100-21
    * **<color #00a2e8>Lot #:</color>** 0218209-1 H1318
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** TGF_beta1
    * **<color #00a2e8>Min:</color>** -17.7146; **<color #00a2e8>Max:</color>** 14.0114
{{:chemogenomics:dose_response:dr_584.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 44ng/mL
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.1
    * **<color #00a2e8>Numbers of reads</color>**: 15554372


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/TGF-beta1_44_ng_per_mL_Round-8_exp528.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='TGF-beta1 44ng/ml R08 exp528'>
{{:chemogenomics:cranks_plots:exp528.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:V:VPS25|VPS25]]|-2.43|0.75|
|[[:human_genes:F:FBXW7|FBXW7]]|-2.30|0.29|
|[[:human_genes:T:TTC4|TTC4]]|-2.29|0.29|
|[[:human_genes:F:FBXO38|FBXO38]]|-2.27|0.29|
|[[:human_genes:C:CDC25A|CDC25A]]|-2.27|0.29|
|[[:human_genes:F:FEN1|FEN1]]|-2.25|0.49|
|[[:human_genes:C:C14orf80|C14orf80]]|-2.24|0.29|
|[[:human_genes:N:NDUFA4L2|NDUFA4L2]]|-2.24|0.29|
|[[:human_genes:G:GEMIN8|GEMIN8]]|-2.12|0.62|
|[[:human_genes:M:MAOA|MAOA]]|-2.09|0.58|
|[[:human_genes:C:CNN1|CNN1]]|-2.07|0.58|
|[[:human_genes:D:DDX25|DDX25]]|-2.04|0.58|
|[[:human_genes:A:ALK|ALK]]|-2.03|0.58|
|[[:human_genes:T:TRIAP1|TRIAP1]]|-2.01|0.69|
|[[:human_genes:T:TCF4|TCF4]]|-1.99|0.58|
|[[:human_genes:S:SNX4|SNX4]]|-1.99|0.58|
|[[:human_genes:R:RNF152|RNF152]]|-1.97|0.58|
|[[:human_genes:A:ACRBP|ACRBP]]|-1.97|0.62|
|[[:human_genes:Z:ZNF430|ZNF430]]|-1.96|0.62|
|[[:human_genes:M:MYH13|MYH13]]|-1.96|0.69|
|[[:human_genes:T:TRIM7|TRIM7]]|-1.94|0.59|
|[[:human_genes:T:TRAPPC4|TRAPPC4]]|-1.94|0.59|
|[[:human_genes:R:RTCB|RTCB]]|-1.93|0.76|
|[[:human_genes:S:SLC22A3|SLC22A3]]|-1.93|0.59|
|[[:human_genes:A:APOBEC3F|APOBEC3F]]|-1.93|0.65|
|[[:human_genes:M:MARK1|MARK1]]|-1.88|0.62|
|[[:human_genes:S:SRPK2|SRPK2]]|-1.88|0.62|
|[[:human_genes:O:OTUD7A|OTUD7A]]|-1.87|0.69|
|[[:human_genes:V:VWDE|VWDE]]|-1.87|0.62|
|[[:human_genes:X:XAB2|XAB2]]|-1.87|0.91|
|[[:human_genes:A:ATP5J2|ATP5J2]]|1.89|0.69|
|[[:human_genes:C:C9orf43|C9orf43]]|1.92|0.59|
|[[:human_genes:C:CXCR6|CXCR6]]|1.93|0.59|
|[[:human_genes:P:PSMC3|PSMC3]]|1.93|0.93|
|[[:human_genes:C:CKAP5|CKAP5]]|1.96|0.93|
|[[:human_genes:N:NOC4L|NOC4L]]|1.97|0.59|
|[[:human_genes:L:LRRC47|LRRC47]]|1.98|0.59|
|[[:human_genes:S:SMC1A|SMC1A]]|1.98|0.86|
|[[:human_genes:S:SLC16A9|SLC16A9]]|1.99|0.59|
|[[:human_genes:P:PCDHGB4|PCDHGB4]]|1.99|0.69|
|[[:human_genes:N:NOL9|NOL9]]|2.00|0.69|
|[[:human_genes:K:KIAA1841|KIAA1841]]|2.02|0.59|
|[[:human_genes:K:KLF16|KLF16]]|2.05|0.59|
|[[:human_genes:M:MPP2|MPP2]]|2.05|0.59|
|[[:human_genes:O:OR4K17|OR4K17]]|2.06|0.59|
|[[:human_genes:A:AVL9|AVL9]]|2.06|0.59|
|[[:human_genes:T:THOC1|THOC1]]|2.06|0.59|
|[[:human_genes:R:REM1|REM1]]|2.07|0.59|
|[[:human_genes:G:GPD1|GPD1]]|2.09|0.59|
|[[:human_genes:D:DNAJA1|DNAJA1]]|2.15|0.59|
|[[:human_genes:F:FTSJ3|FTSJ3]]|2.18|0.59|
|[[:human_genes:F:FUT10|FUT10]]|2.21|0.59|
|[[:human_genes:U:U2AF1|U2AF1]]|2.23|0.86|
|[[:human_genes:N:NAPA|NAPA]]|2.23|0.73|
|[[:human_genes:K:KANK4|KANK4]]|2.35|0.48|
|[[:human_genes:C:CFAP45|CFAP45]]|2.45|0.73|
|[[:human_genes:M:MCM2|MCM2]]|2.48|0.66|
|[[:human_genes:M:MCL1|MCL1]]|2.54|0.48|
|[[:human_genes:K:KPNB1|KPNB1]]|2.62|0.59|
|[[:human_genes:R:RPL30|RPL30]]|2.62|0.85|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>