Trientine 500μM R08 exp534 [The Human Chemical-Genetic Interaction Map Project]

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====== Trientine 500μM R08 exp534 ======
==== Mechanism of Action ====
Copper-selective chelator, enhances renal excretion of copper
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Metal Chelator




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Triethylenetetramine%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 112-24-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5565|5565]]
    * **<color #00a2e8>IUPAC:</color>** %%N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2
    * **<color #00a2e8>INCHI Key:</color>** VILCJCGEZXAXTO-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 146.23
    * **<color #00a2e8>Canonical SMILES:</color>** C(CNCCNCCN)N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** QLVVPSEGLY LIYSQVLFKG QGCPSTHVLL THTISRIAVS YQTKVNLLSA
{{:chemogenomics:structures:chem-0338.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Combi-Blocks
    * **<color #00a2e8>Catalog #:</color>** QF-3275
    * **<color #00a2e8>Lot #:</color>** A32852
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C6H18N4 147.16042; found 147.1617
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Trientine
    * **<color #00a2e8>Min:</color>** 15.8115; **<color #00a2e8>Max:</color>** 99.8213
{{:chemogenomics:dose_response:dr_630.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |3609.0000    |
| IC20  |4737.0000    |
| IC30  |5675.0000    |
| IC40  |6582.0000    |
| IC50  |7540.0000    |
| IC60  |8639.0000    |
| IC70  |10020.0000    |
| IC80  |12000.0000    |
| IC90  |15750.0000    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 500µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.1
    * **<color #00a2e8>Numbers of reads</color>**: 15130273


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|3/4|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Trientine_500uM_Round-8_exp534.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Trientine 500μM R08 exp534'>
{{:chemogenomics:cranks_plots:exp534.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:V:VPS25|VPS25]]|-3.60|0.15|
|[[:human_genes:G:GOT1|GOT1]]|-3.33|<0.01|
|[[:human_genes:O:ODC1|ODC1]]|-2.99|<0.01|
|[[:human_genes:R:RIC8A|RIC8A]]|-2.68|0.04|
|[[:human_genes:M:MDM2|MDM2]]|-2.62|0.23|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.34|0.37|
|[[:human_genes:D:DEFB128|DEFB128]]|-2.32|0.45|
|[[:human_genes:N:NOP16|NOP16]]|-2.16|0.58|
|[[:human_genes:P:PFN1|PFN1]]|-2.15|0.42|
|[[:human_genes:G:GOLGA8H|GOLGA8H]]|-2.13|0.63|
|[[:human_genes:C:CSK|CSK]]|-2.12|0.42|
|[[:human_genes:P:PGGT1B|PGGT1B]]|-2.11|0.42|
|[[:human_genes:M:MNT|MNT]]|-2.11|0.43|
|[[:human_genes:M:MTF2|MTF2]]|-2.10|0.43|
|[[:human_genes:L:LAS1L|LAS1L]]|-2.10|0.63|
|[[:human_genes:N:NUBP1|NUBP1]]|-2.10|0.51|
|[[:human_genes:L:LCE2A|LCE2A]]|-2.06|0.45|
|[[:human_genes:R:RPF1|RPF1]]|-2.05|0.43|
|[[:human_genes:P:PROSC|PROSC]]|-2.05|0.43|
|[[:human_genes:P:PLEC|PLEC]]|-2.05|0.43|
|[[:human_genes:R:RPS28|RPS28]]|-2.04|0.63|
|[[:human_genes:N:NSMCE1|NSMCE1]]|-2.03|0.43|
|[[:human_genes:R:RGS17|RGS17]]|-2.03|0.43|
|[[:human_genes:B:BEX4|BEX4]]|-2.01|0.43|
|[[:human_genes:Z:ZBTB16|ZBTB16]]|-2.00|0.45|
|[[:human_genes:C:CLNS1A|CLNS1A]]|-1.99|0.43|
|[[:human_genes:Z:ZNF507|ZNF507]]|-1.99|0.45|
|[[:human_genes:S:SPATA12|SPATA12]]|-1.96|0.45|
|[[:human_genes:R:RNF121|RNF121]]|-1.95|0.51|
|[[:human_genes:C:CCL2|CCL2]]|-1.95|0.51|
|[[:human_genes:N:NLK|NLK]]|2.14|0.27|
|[[:human_genes:M:MAP6|MAP6]]|2.14|0.19|
|[[:human_genes:D:DAZAP1|DAZAP1]]|2.14|0.15|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|2.15|0.15|
|[[:human_genes:P:PRM3|PRM3]]|2.15|0.23|
|[[:human_genes:F:FPR2|FPR2]]|2.15|0.19|
|[[:human_genes:C:COQ7|COQ7]]|2.20|0.12|
|[[:human_genes:T:TRIM41|TRIM41]]|2.21|0.17|
|[[:human_genes:B:BEND3|BEND3]]|2.21|0.12|
|[[:human_genes:T:TARS2|TARS2]]|2.22|0.17|
|[[:human_genes:D:DNM1L|DNM1L]]|2.22|0.45|
|[[:human_genes:C:C2orf69|C2orf69]]|2.27|0.10|
|[[:human_genes:N:NDUFA2|NDUFA2]]|2.28|0.15|
|[[:human_genes:G:GCNT4|GCNT4]]|2.29|0.10|
|[[:human_genes:G:GRSF1|GRSF1]]|2.34|0.12|
|[[:human_genes:M:MPHOSPH10|MPHOSPH10]]|2.35|0.21|
|[[:human_genes:A:ATP5SL|ATP5SL]]|2.39|0.08|
|[[:human_genes:Z:ZNF544|ZNF544]]|2.40|0.08|
|[[:human_genes:N:NDUFB9|NDUFB9]]|2.41|0.10|
|[[:human_genes:E:EIF3H|EIF3H]]|2.42|0.10|
|[[:human_genes:N:NDUFC1|NDUFC1]]|2.45|0.07|
|[[:human_genes:R:ROBO1|ROBO1]]|2.45|0.19|
|[[:human_genes:L:LEO1|LEO1]]|2.50|0.06|
|[[:human_genes:N:NDUFAF7|NDUFAF7]]|2.50|0.06|
|[[:human_genes:G:GNA11|GNA11]]|2.51|0.08|
|[[:human_genes:N:NPRL3|NPRL3]]|2.68|0.08|
|[[:human_genes:L:LARS2|LARS2]]|2.82|0.04|
|[[:human_genes:A:ASUN|ASUN]]|2.85|0.01|
|[[:human_genes:A:ATP7A|ATP7A]]|4.91|<0.01|
|[[:human_genes:A:ATOX1|ATOX1]]|5.56|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|0.06|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|0.055|<button type="primary" size="small" modal="2">View</button>|
</modal>


<modal id="1" size="lg" title="HMS-I2 10μM R06 exp288  vs  Trientine 500μM R08 exp534">
{{:chemogenomics:comparison_plots:exp288_vs_exp534.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Amiloride 100μM R08 exp447  vs  Trientine 500μM R08 exp534">
{{:chemogenomics:comparison_plots:exp447_vs_exp534.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|mitochondrial respiratory chain complex I assembly|53.11|NDUFAF7,NDUFC1,NDUFB9,DMAC2,NDUFA2|
|NADH dehydrogenase complex assembly|53.11|NDUFAF7,NDUFC1,NDUFB9,DMAC2,NDUFA2|
|mitochondrial respiratory chain complex assembly|31.74|NDUFAF7,NDUFC1,NDUFB9,DMAC2,NDUFA2|
|mitochondrion organization|10.52|ATP7A,NDUFAF7,NDUFC1,NDUFB9,DMAC2,NDUFA2,DNM1L,TP53|
</modal>