UM131593 0.1μM R01 exp58 [The Human Chemical-Genetic Interaction Map Project]

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====== UM131593 0.1μM R01 exp58 ======
==== Mechanism of Action ====
Unknown
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 381.45
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C21H19NO4S
{{:chemogenomics:structures:chem-0038.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** In house - University of Montreal - Chemistry Platform
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** IRIC-004 / sj2182-084 / Batch #01
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** UM0131593
    * **<color #00a2e8>Min:</color>** 0.7950; **<color #00a2e8>Max:</color>** 83.0421
{{:chemogenomics:dose_response:dr_140.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0217    |
| IC30  |0.0436    |
| IC40  |0.0772    |
| IC50  |0.1304    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 01
    * **<color #00a2e8>Dose</color>**: 100nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.0
    * **<color #00a2e8>Numbers of reads</color>**: 15880239


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/UM131593_0.1uM_Round-1_exp58.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='UM131593 0.1μM R01 exp58'>
{{:chemogenomics:cranks_plots:exp58.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:N:NSMCE1|NSMCE1]]|-2.87|0.29|
|[[:human_genes:C:CXorf67|CXorf67]]|-2.70|0.29|
|[[:human_genes:K:KARS|KARS]]|-2.48|0.76|
|[[:human_genes:G:GMPPB|GMPPB]]|-2.43|0.53|
|[[:human_genes:I:ICA1|ICA1]]|-2.42|0.29|
|[[:human_genes:T:TACC3|TACC3]]|-2.38|0.53|
|[[:human_genes:P:PTDSS1|PTDSS1]]|-2.37|0.29|
|[[:human_genes:A:ARL2|ARL2]]|-2.36|0.31|
|[[:human_genes:A:AKR1C1|AKR1C1]]|-2.30|0.68|
|[[:human_genes:H:HEATR3|HEATR3]]|-2.29|0.68|
|[[:human_genes:C:CHMP6|CHMP6]]|-2.27|0.29|
|[[:human_genes:Z:ZCRB1|ZCRB1]]|-2.25|0.53|
|[[:human_genes:C:CCDC177|CCDC177]]|-2.24|0.53|
|[[:human_genes:M:MPP5|MPP5]]|-2.24|0.73|
|[[:human_genes:B:BCORL1|BCORL1]]|-2.19|0.82|
|[[:human_genes:A:ARPC5|ARPC5]]|-2.16|0.53|
|[[:human_genes:I:IPO9|IPO9]]|-2.15|0.75|
|[[:human_genes:A:ATXN10|ATXN10]]|-2.15|0.53|
|[[:human_genes:O:OR5K3|OR5K3]]|-2.13|0.75|
|[[:human_genes:G:GAK|GAK]]|-2.11|0.53|
|[[:human_genes:S:SAMD9L|SAMD9L]]|-2.08|0.93|
|[[:human_genes:T:TCF4|TCF4]]|-2.08|0.53|
|[[:human_genes:E:ELMSAN1|ELMSAN1]]|-2.07|0.73|
|[[:human_genes:T:TIMM21|TIMM21]]|-2.07|0.73|
|[[:human_genes:N:NEUROD1|NEUROD1]]|-2.05|0.78|
|[[:human_genes:T:TPTE2|TPTE2]]|-2.04|0.53|
|[[:human_genes:H:HIST1H4C|HIST1H4C]]|-2.03|0.75|
|[[:human_genes:T:TBCD|TBCD]]|-2.00|0.82|
|[[:human_genes:C:C11orf74|C11orf74]]|-1.99|0.82|
|[[:human_genes:C:COLCA2|COLCA2]]|-1.99|0.89|
|[[:human_genes:M:MAT2A|MAT2A]]|2.09|0.76|
|[[:human_genes:A:ANKRD40|ANKRD40]]|2.15|0.67|
|[[:human_genes:D:DNAJC16|DNAJC16]]|2.15|0.64|
|[[:human_genes:I:IER3IP1|IER3IP1]]|2.16|0.74|
|[[:human_genes:P:P2RX5|P2RX5]]|2.17|0.68|
|[[:human_genes:A:AKR1C4|AKR1C4]]|2.19|0.57|
|[[:human_genes:C:CCND3|CCND3]]|2.21|0.67|
|[[:human_genes:M:MTERF|MTERF]]|2.22|0.57|
|[[:human_genes:M:MYO9A|MYO9A]]|2.23|0.74|
|[[:human_genes:S:SPTLC3|SPTLC3]]|2.23|0.67|
|[[:human_genes:U:UPF1|UPF1]]|2.29|0.57|
|[[:human_genes:B:BPNT1|BPNT1]]|2.30|0.47|
|[[:human_genes:U:UBA52|UBA52]]|2.33|0.77|
|[[:human_genes:R:RPSA|RPSA]]|2.33|0.77|
|[[:human_genes:N:NUP155|NUP155]]|2.34|0.61|
|[[:human_genes:A:ATXN1|ATXN1]]|2.35|0.67|
|[[:human_genes:C:C21orf140|C21orf140]]|2.36|0.70|
|[[:human_genes:P:PSMA5|PSMA5]]|2.39|0.57|
|[[:human_genes:D:DNAH8|DNAH8]]|2.42|0.57|
|[[:human_genes:G:GOLGA8H|GOLGA8H]]|2.44|0.68|
|[[:human_genes:S:SNRNP200|SNRNP200]]|2.49|0.68|
|[[:human_genes:T:TMEM169|TMEM169]]|2.52|0.21|
|[[:human_genes:P:PSMD1|PSMD1]]|2.61|0.57|
|[[:human_genes:M:MPHOSPH10|MPHOSPH10]]|2.64|0.71|
|[[:human_genes:S:STK38L|STK38L]]|2.70|0.43|
|[[:human_genes:M:MFRP|MFRP]]|2.71|0.67|
|[[:human_genes:O:ORC6|ORC6]]|2.73|0.66|
|[[:human_genes:P:PMP22|PMP22]]|2.79|0.21|
|[[:human_genes:P:PHYH|PHYH]]|2.90|0.21|
|[[:human_genes:T:TPM2|TPM2]]|2.95|0.21|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|0.092|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|0.081|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|0.068|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|0.062|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|0.056|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|0.052|<button type="primary" size="small" modal="6">View</button>|
</modal>


<modal id="1" size="lg" title="Taxol 0.002μM R01 exp54  vs  UM131593 0.1μM R01 exp58">
{{:chemogenomics:comparison_plots:exp54_vs_exp58.png?nolink |}}
</modal>

<modal id="2" size="lg" title="BI-2536 0.001μM R01 exp41  vs  UM131593 0.1μM R01 exp58">
{{:chemogenomics:comparison_plots:exp41_vs_exp58.png?nolink |}}
</modal>

<modal id="3" size="lg" title="BI-6727 0.001μM R01 exp42  vs  UM131593 0.1μM R01 exp58">
{{:chemogenomics:comparison_plots:exp42_vs_exp58.png?nolink |}}
</modal>

<modal id="4" size="lg" title="NFN1 0.1μM R01 exp49  vs  UM131593 0.1μM R01 exp58">
{{:chemogenomics:comparison_plots:exp49_vs_exp58.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53  vs  UM131593 0.1μM R01 exp58">
{{:chemogenomics:comparison_plots:exp53_vs_exp58.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  UM131593 0.1μM R01 exp58">
{{:chemogenomics:comparison_plots:exp45_vs_exp58.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>