Prochlorperazine 5.2μM R02 exp77 [The Human Chemical-Genetic Interaction Map Project]

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====== Prochlorperazine 5.2μM R02 exp77 ======
==== Mechanism of Action ====
Antagonist of DRD2 receptors, used to treat nausea, schizophrenia, migraines, anxiety
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / GPCR Antagonist




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Prochlorperazine maleate%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 84-02-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5281032|5281032]]
    * **<color #00a2e8>IUPAC:</color>** %%(Z)-but-2-enedioic acid;2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
    * **<color #00a2e8>INCHI Key:</color>** DSKIOWHQLUWFLG-SPIKMXEPSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 606.1
    * **<color #00a2e8>Canonical SMILES:</color>** CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** CN1CCN(CC1)CCCN2C3=C(SC4=CC=CC=C24)C=CC(=C3)Cl.C(=C\\C(=O)O)\\C(=O)O.C(=C\\C(=O)O)\\C(=O)O
    * **<color #00a2e8>Molecular Formula:</color>** C28H32ClN3O8S
{{:chemogenomics:structures:chem-0053.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Tocris Bioscience
    * **<color #00a2e8>Catalog #:</color>** 3287
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H24ClN3S 374.14522; found 374.14674
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Prochlorperazine
    * **<color #00a2e8>Min:</color>** -0.6151; **<color #00a2e8>Max:</color>** 98.0607
{{:chemogenomics:dose_response:dr_45.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |4.6246    |
| IC30  |5.1702    |
| IC40  |5.6652    |
| IC50  |6.1610    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 02
    * **<color #00a2e8>Dose</color>**: 5.2µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.8
    * **<color #00a2e8>Numbers of reads</color>**: 9745730


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Prochlorperazine_5.2uM_Round-2_exp77.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Prochlorperazine 5.2μM R02 exp77'>
{{:chemogenomics:cranks_plots:exp77.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PRAMEF25|PRAMEF25]]|-3.12|0.51|
|[[:human_genes:P:PRAMEF26|PRAMEF26]]|-3.08|0.51|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.50|0.24|
|[[:human_genes:C:CETN1|CETN1]]|-2.41|0.29|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.38|0.29|
|[[:human_genes:R:RAB7A|RAB7A]]|-2.37|0.24|
|[[:human_genes:A:ARL1|ARL1]]|-2.34|0.24|
|[[:human_genes:G:GPR107|GPR107]]|-2.34|0.24|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.26|0.59|
|[[:human_genes:M:METTL16|METTL16]]|-2.23|0.75|
|[[:human_genes:C:CTC1|CTC1]]|-2.20|0.50|
|[[:human_genes:U:U2AF1|U2AF1]]|-2.17|0.52|
|[[:human_genes:K:KDSR|KDSR]]|-2.14|0.43|
|[[:human_genes:G:GAGE2A|GAGE2A]]|-2.14|0.75|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-2.12|0.43|
|[[:human_genes:R:R3HCC1|R3HCC1]]|-2.06|0.62|
|[[:human_genes:N:NDOR1|NDOR1]]|-2.06|0.51|
|[[:human_genes:K:KAT7|KAT7]]|-2.05|0.51|
|[[:human_genes:M:MTX1|MTX1]]|-2.03|0.51|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.00|0.51|
|[[:human_genes:C:CASKIN2|CASKIN2]]|-2.00|0.51|
|[[:human_genes:E:ELOVL5|ELOVL5]]|-1.99|0.51|
|[[:human_genes:T:TAX1BP1|TAX1BP1]]|-1.98|0.51|
|[[:human_genes:T:TMEM147|TMEM147]]|-1.96|0.51|
|[[:human_genes:T:TMEM189-UBE2V1|TMEM189-UBE2V1]]|-1.96|0.51|
|[[:human_genes:C:C1orf112|C1orf112]]|-1.94|0.51|
|[[:human_genes:M:MYPN|MYPN]]|-1.93|0.51|
|[[:human_genes:R:RAD51B|RAD51B]]|-1.92|0.51|
|[[:human_genes:K:KRI1|KRI1]]|-1.91|0.86|
|[[:human_genes:F:FAM21B|FAM21B]]|-1.91|0.51|
|[[:human_genes:P:PDHB|PDHB]]|1.95|0.63|
|[[:human_genes:C:CCM2L|CCM2L]]|1.96|0.63|
|[[:human_genes:C:C18orf32|C18orf32]]|1.96|0.80|
|[[:human_genes:E:EZH1|EZH1]]|1.97|0.63|
|[[:human_genes:P:PSMC2|PSMC2]]|1.97|0.80|
|[[:human_genes:C:C12orf77|C12orf77]]|1.98|0.58|
|[[:human_genes:S:STUB1|STUB1]]|1.99|0.58|
|[[:human_genes:K:KANSL2|KANSL2]]|1.99|0.63|
|[[:human_genes:S:SSSCA1|SSSCA1]]|2.01|0.57|
|[[:human_genes:O:OR10H4|OR10H4]]|2.02|0.57|
|[[:human_genes:C:C18orf54|C18orf54]]|2.02|0.57|
|[[:human_genes:A:ARMC12|ARMC12]]|2.04|0.57|
|[[:human_genes:C:CCL5|CCL5]]|2.09|0.57|
|[[:human_genes:C:C9orf3|C9orf3]]|2.20|0.57|
|[[:human_genes:I:ISY1|ISY1]]|2.23|0.70|
|[[:human_genes:R:RRM2|RRM2]]|2.23|0.70|
|[[:human_genes:L:LANCL2|LANCL2]]|2.30|0.57|
|[[:human_genes:A:AHCTF1|AHCTF1]]|2.32|0.57|
|[[:human_genes:T:TRAIP|TRAIP]]|2.32|0.68|
|[[:human_genes:E:EXOSC4|EXOSC4]]|2.43|0.63|
|[[:human_genes:G:GABBR1|GABBR1]]|2.48|0.57|
|[[:human_genes:C:CKAP5|CKAP5]]|2.49|0.68|
|[[:human_genes:Z:ZNF688|ZNF688]]|2.49|0.57|
|[[:human_genes:L:LEUTX|LEUTX]]|2.54|0.57|
|[[:human_genes:B:BAGE4|BAGE4]]|2.55|0.70|
|[[:human_genes:B:BAGE5|BAGE5]]|2.55|0.70|
|[[:human_genes:B:BAGE2|BAGE2]]|2.55|0.70|
|[[:human_genes:B:BAGE3|BAGE3]]|2.55|0.70|
|[[:human_genes:B:BAGE|BAGE]]|2.56|0.70|
|[[:human_genes:S:SHFM1|SHFM1]]|2.73|0.57|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.091|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.077|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp187|proTAME 5μM R04 exp187]]|0.062|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|0.061|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.056|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|0.054|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|0.053|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.051|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.085|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.081|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.076|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.074|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|0.069|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.066|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|0.066|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.058|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.056|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|0.056|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|0.055|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.052|<button type="primary" size="small" modal="20">View</button>|
</modal>


<modal id="1" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp77.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp422_vs_exp77.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  proTAME 5μM R04 exp187">
{{:chemogenomics:comparison_plots:exp187_vs_exp77.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  SGC2043 10μM R03 exp152">
{{:chemogenomics:comparison_plots:exp152_vs_exp77.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp530_vs_exp77.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  Wortmannin 0.5μM R00 exp37">
{{:chemogenomics:comparison_plots:exp37_vs_exp77.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  Rifampicin 1μM R00 exp31">
{{:chemogenomics:comparison_plots:exp31_vs_exp77.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp77_vs_exp90.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp457_vs_exp77.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp344_vs_exp77.png?nolink |}}
</modal>

<modal id="11" size="lg" title="NN-Dimethylsphingosine 2.5μM R08 exp508  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp508_vs_exp77.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp465_vs_exp77.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Hydroxychloroquine 30μM R08 exp490  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp490_vs_exp77.png?nolink |}}
</modal>

<modal id="14" size="lg" title="CCT251545 20μM R07 exp326  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp326_vs_exp77.png?nolink |}}
</modal>

<modal id="15" size="lg" title="BRD2 inhibitor II 20μM R07 exp341  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp341_vs_exp77.png?nolink |}}
</modal>

<modal id="16" size="lg" title="BH1 1μM R04 exp169  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp169_vs_exp77.png?nolink |}}
</modal>

<modal id="17" size="lg" title="FTY720 3μM R08 exp483  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp483_vs_exp77.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Myriocin 25μM R06 exp293  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp293_vs_exp77.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Caffeine 2600μM R08 exp463  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp463_vs_exp77.png?nolink |}}
</modal>

<modal id="20" size="lg" title="EPZ-5676 30μM R05 exp233  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp233_vs_exp77.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>