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Ask your administrator if you think this is wrong. ====== Torin1 0.08μM R02 exp82 ====== ==== Mechanism of Action ==== Inhibits mTORC1 and mTORC2, ATP competitive * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / mTOR inhibitor * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / Kinase Inhibitor ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%Torin 1%% * **<color #00a2e8>Synonyms:</color>** N/A * **<color #00a2e8>CAS #:</color>** 1222998-36-8 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/49836027|49836027]] * **<color #00a2e8>IUPAC:</color>** %%1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-one%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3 * **<color #00a2e8>INCHI Key:</color>** AKCRNFFTGXBONI-UHFFFAOYSA-N * **<color #00a2e8>Molecular Weight:</color>** 607.6 * **<color #00a2e8>Canonical SMILES:</color>** CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F * **<color #00a2e8>Isomeric SMILES:</color>** N/A * **<color #00a2e8>Molecular Formula:</color>** C35H28F3N5O2 {{:chemogenomics:structures:chem-0058.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** Selleck Chemicals * **<color #00a2e8>Catalog #:</color>** S2827 * **<color #00a2e8>Lot #:</color>** N/A </panel> <panel title='Compound Characterization' collapsed='true'> * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C35H28F3N5O2 608.22679; found 608.22884 </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** Torin1 * **<color #00a2e8>Min:</color>** -11.3340; **<color #00a2e8>Max:</color>** 60.4301 {{:chemogenomics:dose_response:dr_24.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |N/A | | IC20 |0.0460 | | IC30 |0.0897 | | IC40 |0.1551 | | IC50 |0.2563 | | IC60 |N/A | | IC70 |N/A | | IC80 |N/A | | IC90 |N/A | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 02 * **<color #00a2e8>Dose</color>**: 80nM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: 3.7 * **<color #00a2e8>Numbers of reads</color>**: 11967482 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |0/9|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Torin1_0.08uM_Round-2_exp82.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='Torin1 0.08μM R02 exp82'> {{:chemogenomics:cranks_plots:exp82.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:U:UMPS|UMPS]]|-3.24|0.33| |[[:human_genes:T:THOC7|THOC7]]|-2.62|0.11| |[[:human_genes:T:TUBB|TUBB]]|-2.62|0.22| |[[:human_genes:U:UXS1|UXS1]]|-2.60|0.11| |[[:human_genes:C:CDK6|CDK6]]|-2.49|0.13| |[[:human_genes:M:MSH5|MSH5]]|-2.43|0.22| |[[:human_genes:S:SAFB|SAFB]]|-2.31|0.38| |[[:human_genes:P:PAG1|PAG1]]|-2.29|0.22| |[[:human_genes:R:RRAGA|RRAGA]]|-2.25|0.38| |[[:human_genes:D:DROSHA|DROSHA]]|-2.20|0.39| |[[:human_genes:L:LAMTOR4|LAMTOR4]]|-2.12|0.38| |[[:human_genes:R:RHEB|RHEB]]|-2.10|0.38| |[[:human_genes:P:PACSIN2|PACSIN2]]|-2.08|0.38| |[[:human_genes:Z:ZFP91|ZFP91]]|-2.07|0.38| |[[:human_genes:T:TFAP2E|TFAP2E]]|-2.07|0.39| |[[:human_genes:A:ADAM17|ADAM17]]|-2.06|0.39| |[[:human_genes:M:MCM5|MCM5]]|-2.06|0.48| |[[:human_genes:S:SLC9A3R1|SLC9A3R1]]|-2.06|0.38| |[[:human_genes:N:NRAS|NRAS]]|-2.05|0.39| |[[:human_genes:S:SCAPER|SCAPER]]|-2.05|0.39| |[[:human_genes:S:SENP1|SENP1]]|-2.04|0.38| |[[:human_genes:P:PSMA1|PSMA1]]|-2.04|0.65| |[[:human_genes:R:RSRC2|RSRC2]]|-2.03|0.83| |[[:human_genes:G:GTF2E2|GTF2E2]]|-2.03|0.39| |[[:human_genes:U:U2AF2|U2AF2]]|-2.02|0.50| |[[:human_genes:A:ACTL6A|ACTL6A]]|-2.01|0.65| |[[:human_genes:N:NPIPA5|NPIPA5]]|-1.99|0.65| |[[:human_genes:S:SCNN1G|SCNN1G]]|-1.97|0.39| |[[:human_genes:C:CDC45|CDC45]]|-1.96|0.83| |[[:human_genes:A:ACTB|ACTB]]|-1.96|0.50| |[[:human_genes:D:DEFB135|DEFB135]]|2.10|0.24| |[[:human_genes:C:CMAS|CMAS]]|2.11|0.20| |[[:human_genes:K:KDM8|KDM8]]|2.12|0.34| |[[:human_genes:M:MTHFD1|MTHFD1]]|2.12|0.49| |[[:human_genes:C:COA6|COA6]]|2.13|0.18| |[[:human_genes:M:MDH2|MDH2]]|2.14|0.22| |[[:human_genes:M:MRPS18A|MRPS18A]]|2.14|0.22| |[[:human_genes:P:PRKACA|PRKACA]]|2.18|0.15| |[[:human_genes:E:EIF4A1|EIF4A1]]|2.22|0.20| |[[:human_genes:A:ATIC|ATIC]]|2.22|0.20| |[[:human_genes:M:MEMO1|MEMO1]]|2.22|0.13| |[[:human_genes:N:NDUFAF3|NDUFAF3]]|2.25|0.24| |[[:human_genes:W:WBSCR16|WBSCR16]]|2.34|0.21| |[[:human_genes:A:ATP5F1|ATP5F1]]|2.37|0.12| |[[:human_genes:T:TRMT6|TRMT6]]|2.45|0.08| |[[:human_genes:K:KIAA0195|KIAA0195]]|2.46|0.08| |[[:human_genes:P:PTPMT1|PTPMT1]]|2.48|0.22| |[[:human_genes:G:GSK3A|GSK3A]]|2.49|0.04| |[[:human_genes:G:GSK3B|GSK3B]]|2.53|0.04| |[[:human_genes:A:ARID4B|ARID4B]]|2.55|0.06| |[[:human_genes:B:BTK|BTK]]|2.57|0.06| |[[:human_genes:I:IBA57|IBA57]]|2.59|0.03| |[[:human_genes:M:MRPL28|MRPL28]]|2.69|0.07| |[[:human_genes:F:FIBP|FIBP]]|2.78|0.03| |[[:human_genes:M:METTL17|METTL17]]|2.85|0.03| |[[:human_genes:P:PPP3R1|PPP3R1]]|2.85|0.01| |[[:human_genes:P:PPP3CA|PPP3CA]]|2.92|<0.01| |[[:human_genes:R:RPL36A-HNRNPH2|RPL36A-HNRNPH2]]|2.94|0.45| |[[:human_genes:P:PGM3|PGM3]]|3.09|<0.01| |[[:human_genes:E:EIF4EBP1|EIF4EBP1]]|3.51|<0.01| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp492|iCRT14 30μM R08 exp492]]|0.054|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp70|INK128 0.2μM R02 exp70]]|0.116|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|0.071|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|0.063|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp306|Rapamycin 2μM R07 exp306]]|0.062|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp30|Rapamycin 10μM R00 exp30]]|0.056|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp29|Rapamycin 1μM R00 exp29]]|0.055|<button type="primary" size="small" modal="7">View</button>| |[[:results:exp216|Erlotinib 10μM R05 exp216]]|0.054|<button type="primary" size="small" modal="8">View</button>| </modal> <modal id="1" size="lg" title="Torin1 0.08μM R02 exp82 vs iCRT14 30μM R08 exp492"> {{:chemogenomics:comparison_plots:exp492_vs_exp82.png?nolink |}} </modal> <modal id="2" size="lg" title="INK128 0.2μM R02 exp70 vs Torin1 0.08μM R02 exp82"> {{:chemogenomics:comparison_plots:exp70_vs_exp82.png?nolink |}} </modal> <modal id="3" size="lg" title="KU-0063794 3.8μM R02 exp71 vs Torin1 0.08μM R02 exp82"> {{:chemogenomics:comparison_plots:exp71_vs_exp82.png?nolink |}} </modal> <modal id="4" size="lg" title="Rapamycin 0.001μM R08 exp429 vs Torin1 0.08μM R02 exp82"> {{:chemogenomics:comparison_plots:exp429_vs_exp82.png?nolink |}} </modal> <modal id="5" size="lg" title="Rapamycin 2μM R07 exp306 vs Torin1 0.08μM R02 exp82"> {{:chemogenomics:comparison_plots:exp306_vs_exp82.png?nolink |}} </modal> <modal id="6" size="lg" title="Rapamycin 10μM R00 exp30 vs Torin1 0.08μM R02 exp82"> {{:chemogenomics:comparison_plots:exp30_vs_exp82.png?nolink |}} </modal> <modal id="7" size="lg" title="Rapamycin 1μM R00 exp29 vs Torin1 0.08μM R02 exp82"> {{:chemogenomics:comparison_plots:exp29_vs_exp82.png?nolink |}} </modal> <modal id="8" size="lg" title="Erlotinib 10μM R05 exp216 vs Torin1 0.08μM R02 exp82"> {{:chemogenomics:comparison_plots:exp216_vs_exp82.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal> Last modified: 2026/01/15 21:36by 127.0.0.1