DABN racemic mixture R03 exp93 [The Human Chemical-Genetic Interaction Map Project]

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====== DABN racemic mixture R03 exp93 ======
==== Mechanism of Action ====
Unknown, (R) atropisomer of 1,1'-Binaphthyl-2,2'-diamine
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit




==== Technical Notes ====

<accordion collapsed='true'>
=== (R)-DABN ===
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%[1,1'-Binaphthalene]-2,2'-diamine%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 18741-85-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/20571|20571]]
    * **<color #00a2e8>IUPAC:</color>** %%1-(2-aminonaphthalen-1-yl)naphthalen-2-amine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H16N2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12H,21-22H2
    * **<color #00a2e8>INCHI Key:</color>** DDAPSNKEOHDLKB-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 284.4
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)N)N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C20H16N2
{{:chemogenomics:structures:chem-0067.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Chem-Impex International
    * **<color #00a2e8>Catalog #:</color>** 24622
    * **<color #00a2e8>Lot #:</color>** 001702-20130307
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H16N2 285.13862; found 285.13901
</panel>





=== (S)-DABN ===
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%[1,1'-Binaphthalene]-2,2'-diamine%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 18531-95-8
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/20571|20571]]
    * **<color #00a2e8>IUPAC:</color>** %%1-(2-aminonaphthalen-1-yl)naphthalen-2-amine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H16N2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12H,21-22H2
    * **<color #00a2e8>INCHI Key:</color>** DDAPSNKEOHDLKB-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 284.4
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)N)N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C20H16N2
{{:chemogenomics:structures:chem-0068.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Chem-Impex International
    * **<color #00a2e8>Catalog #:</color>** 24613
    * **<color #00a2e8>Lot #:</color>** 001702-20130513
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H16N2 285.13862; found 285.13895
</panel>




===(R)-DABN+(S)-DABN===
<panel title='Dose Response Curve'>
Dose response curve not available for this combination.
However, the dose response curve for (S)-DABN is available at:
  * [[results:exp112|exp112]]
</panel>




</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 10µM + 10µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: -0.2
    * **<color #00a2e8>Numbers of reads</color>**: 11041737


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|2/144|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/DABN_Mix_from_Luisa_Round-3_exp93.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='DABN racemic mixture R03 exp93'>
{{:chemogenomics:cranks_plots:exp93.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:Z:ZNF83|ZNF83]]|-3.00|0.02|
|[[:human_genes:E:EIF5B|EIF5B]]|-2.87|0.53|
|[[:human_genes:N:NDUFA4L2|NDUFA4L2]]|-2.82|0.03|
|[[:human_genes:T:TFPT|TFPT]]|-2.77|0.11|
|[[:human_genes:S:SNRNP70|SNRNP70]]|-2.74|0.09|
|[[:human_genes:D:DEFB128|DEFB128]]|-2.68|0.30|
|[[:human_genes:P:PEBP4|PEBP4]]|-2.47|0.11|
|[[:human_genes:V:VPS25|VPS25]]|-2.40|0.47|
|[[:human_genes:D:DUSP5|DUSP5]]|-2.32|0.19|
|[[:human_genes:A:ATP8B2|ATP8B2]]|-2.30|0.40|
|[[:human_genes:P:PPM1D|PPM1D]]|-2.27|0.35|
|[[:human_genes:G:GPX8|GPX8]]|-2.27|0.22|
|[[:human_genes:N:NAPA|NAPA]]|-2.24|0.40|
|[[:human_genes:W:WDR61|WDR61]]|-2.24|0.40|
|[[:human_genes:S:SMG7|SMG7]]|-2.23|0.45|
|[[:human_genes:S:SMG5|SMG5]]|-2.22|0.61|
|[[:human_genes:S:SARS|SARS]]|-2.21|0.63|
|[[:human_genes:T:TMEM134|TMEM134]]|-2.19|0.40|
|[[:human_genes:Z:ZNF681|ZNF681]]|-2.18|0.61|
|[[:human_genes:P:PSMC5|PSMC5]]|-2.16|0.45|
|[[:human_genes:C:COL2A1|COL2A1]]|-2.14|0.40|
|[[:human_genes:C:CA10|CA10]]|-2.13|0.35|
|[[:human_genes:R:RPSA|RPSA]]|-2.10|0.63|
|[[:human_genes:N:NAA11|NAA11]]|-2.10|0.40|
|[[:human_genes:M:MFAP1|MFAP1]]|-2.08|0.45|
|[[:human_genes:R:RAD51|RAD51]]|-2.05|0.60|
|[[:human_genes:Z:ZNF768|ZNF768]]|-2.03|0.40|
|[[:human_genes:N:NHP2L1|NHP2L1]]|-2.03|0.59|
|[[:human_genes:T:TSG101|TSG101]]|-2.03|0.40|
|[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.02|0.40|
|[[:human_genes:H:HOXA6|HOXA6]]|3.22|<0.01|
|[[:human_genes:C:CDCA2|CDCA2]]|3.22|<0.01|
|[[:human_genes:R:RNMT|RNMT]]|3.29|<0.01|
|[[:human_genes:C:CHN2|CHN2]]|3.30|<0.01|
|[[:human_genes:M:MEOX2|MEOX2]]|3.32|<0.01|
|[[:human_genes:A:AMZ1|AMZ1]]|3.39|<0.01|
|[[:human_genes:F:FBXL18|FBXL18]]|3.41|<0.01|
|[[:human_genes:Z:ZDHHC4|ZDHHC4]]|3.41|<0.01|
|[[:human_genes:S:SDK1|SDK1]]|3.42|<0.01|
|[[:human_genes:L:LFNG|LFNG]]|3.42|<0.01|
|[[:human_genes:E:ETV1|ETV1]]|3.54|<0.01|
|[[:human_genes:M:MYL7|MYL7]]|3.66|<0.01|
|[[:human_genes:H:HECW1|HECW1]]|3.72|<0.01|
|[[:human_genes:R:RBM14-RBM4|RBM14-RBM4]]|3.74|<0.01|
|[[:human_genes:C:CHST12|CHST12]]|3.76|<0.01|
|[[:human_genes:R:RBM14|RBM14]]|3.84|<0.01|
|[[:human_genes:U:USP42|USP42]]|3.89|<0.01|
|[[:human_genes:T:TP53|TP53]]|4.01|<0.01|
|[[:human_genes:G:GRIFIN|GRIFIN]]|4.25|<0.01|
|[[:human_genes:H:HOXA9|HOXA9]]|4.54|<0.01|
|[[:human_genes:F:FNTB|FNTB]]|4.58|<0.01|
|[[:human_genes:Z:ZWILCH|ZWILCH]]|4.86|<0.01|
|[[:human_genes:M:MAD2L1BP|MAD2L1BP]]|4.93|<0.01|
|[[:human_genes:B:BUB1B|BUB1B]]|5.08|<0.01|
|[[:human_genes:M:MAD2L1|MAD2L1]]|5.66|<0.01|
|[[:human_genes:B:BUB3|BUB3]]|6.00|<0.01|
|[[:human_genes:M:MAD1L1|MAD1L1]]|6.09|<0.01|
|[[:human_genes:T:TRIP13|TRIP13]]|7.09|<0.01|
|[[:human_genes:K:KNTC1|KNTC1]]|7.60|<0.01|
|[[:human_genes:Z:ZW10|ZW10]]|8.09|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|0.338|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|0.274|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|0.273|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|0.262|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|0.246|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|0.229|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|0.185|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|0.185|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.085|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.076|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.057|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.054|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.053|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.145|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.082|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.059|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.055|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.054|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp17|DABN 20μM R00 exp17]]|0.052|<button type="primary" size="small" modal="19">View</button>|
</modal>


<modal id="1" size="lg" title="DABN racemic mixture R03 exp93  vs  Nocodazole 0.1μM R03 exp94">
{{:chemogenomics:comparison_plots:exp93_vs_exp94.png?nolink |}}
</modal>

<modal id="2" size="lg" title="DABN racemic mixture R03 exp93  vs  Rotenone 2μM R00 exp33">
{{:chemogenomics:comparison_plots:exp33_vs_exp93.png?nolink |}}
</modal>

<modal id="3" size="lg" title="DABN racemic mixture R03 exp93  vs  SB743921 0.001μM R05 exp244">
{{:chemogenomics:comparison_plots:exp244_vs_exp93.png?nolink |}}
</modal>

<modal id="4" size="lg" title="DABN racemic mixture R03 exp93  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp93.png?nolink |}}
</modal>

<modal id="5" size="lg" title="DABN racemic mixture R03 exp93  vs  HMS-I1 10μM R06 exp256">
{{:chemogenomics:comparison_plots:exp256_vs_exp93.png?nolink |}}
</modal>

<modal id="6" size="lg" title="DABN racemic mixture R03 exp93  vs  Nocodazole 0.2μM R00 exp24">
{{:chemogenomics:comparison_plots:exp24_vs_exp93.png?nolink |}}
</modal>

<modal id="7" size="lg" title="DABN racemic mixture R03 exp93  vs  Nocodazole 0.2μM R02 exp64">
{{:chemogenomics:comparison_plots:exp64_vs_exp93.png?nolink |}}
</modal>

<modal id="8" size="lg" title="DABN racemic mixture R03 exp93  vs  Vinblastine 0.015μM R05 exp208">
{{:chemogenomics:comparison_plots:exp208_vs_exp93.png?nolink |}}
</modal>

<modal id="9" size="lg" title="DABN racemic mixture R03 exp93  vs  GSK461364A 0.1μM R03 exp126">
{{:chemogenomics:comparison_plots:exp126_vs_exp93.png?nolink |}}
</modal>

<modal id="10" size="lg" title="DABN racemic mixture R03 exp93  vs  Vinblastine 0.2μM R03 exp108">
{{:chemogenomics:comparison_plots:exp108_vs_exp93.png?nolink |}}
</modal>

<modal id="11" size="lg" title="DABN racemic mixture R03 exp93  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp503_vs_exp93.png?nolink |}}
</modal>

<modal id="12" size="lg" title="DABN racemic mixture R03 exp93  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp478_vs_exp93.png?nolink |}}
</modal>

<modal id="13" size="lg" title="DABN racemic mixture R03 exp93  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp531_vs_exp93.png?nolink |}}
</modal>

<modal id="14" size="lg" title="BI-6727 0.04μM R03 exp98  vs  DABN racemic mixture R03 exp93">
{{:chemogenomics:comparison_plots:exp93_vs_exp98.png?nolink |}}
</modal>

<modal id="15" size="lg" title="BI-2536 0.02μM R03 exp96  vs  DABN racemic mixture R03 exp93">
{{:chemogenomics:comparison_plots:exp93_vs_exp96.png?nolink |}}
</modal>

<modal id="16" size="lg" title="CI-1040 9.5μM R08 exp472  vs  DABN racemic mixture R03 exp93">
{{:chemogenomics:comparison_plots:exp472_vs_exp93.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Benzoate 20000μM R08 exp456  vs  DABN racemic mixture R03 exp93">
{{:chemogenomics:comparison_plots:exp456_vs_exp93.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Centrinone 0.5μM R07 exp343  vs  DABN racemic mixture R03 exp93">
{{:chemogenomics:comparison_plots:exp343_vs_exp93.png?nolink |}}
</modal>

<modal id="19" size="lg" title="DABN 20μM R00 exp17  vs  DABN racemic mixture R03 exp93">
{{:chemogenomics:comparison_plots:exp17_vs_exp93.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|mitotic spindle assembly checkpoint signaling|157.90|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|spindle assembly checkpoint signaling|157.90|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|mitotic spindle checkpoint signaling|157.90|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|negative regulation of mitotic sister chromatid separation|142.62|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|negative regulation of mitotic sister chromatid segregation|142.62|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|negative regulation of metaphase/anaphase transition of cell cycle|133.97|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|negative regulation of chromosome segregation|133.97|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|negative regulation of chromosome separation|133.97|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|spindle checkpoint signaling|133.39|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,BUB1B,ZWILCH|
|negative regulation of mitotic metaphase/anaphase transition|124.79|ZW10,KNTC1,TRIP13,MAD1L1,MAD2L1,BUB1B,ZWILCH|
|negative regulation of sister chromatid segregation|124.79|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,BUB1B,ZWILCH|
|negative regulation of nuclear division|96.11|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,ZWILCH|
|regulation of mitotic sister chromatid segregation|93.84|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,MAD2L1BP,ZWILCH|
|regulation of mitotic sister chromatid separation|76.23|ZW10,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,MAD2L1BP,ZWILCH|
|regulation of chromosome separation|68.13|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,MAD2L1BP,ZWILCH|
|regulation of mitotic metaphase/anaphase transition|55.88|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,MAD2L1BP,ZWILCH|
|regulation of metaphase/anaphase transition of cell cycle|54.06|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,MAD2L1BP,ZWILCH|
|regulation of mitotic nuclear division|47.23|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,MAD2L1BP,ZWILCH,CDCA2|
|regulation of chromosome segregation|43.86|ZW10,KNTC1,TRIP13,MAD1L1,BUB3,MAD2L1,BUB1B,MAD2L1BP,ZWILCH,CDCA2|
</modal>