| Both sides previous revision Previous revision | |
| results [2025/12/03 20:10] – tyersadmin | results [2026/02/19 16:28] (current) – external edit 127.0.0.1 |
|---|
| <sortable> | <sortable> |
| |< 100% 15% 15% 20% 35% >| | |< 100% 15% 15% 20% 35% >| |
| ^Compound/Condition^Experiments^Compound/Target Mechanism^Compound Classification^ | ^Substance/Condition^Experiments^Description/Target Mechanism^Classification^ |
| |5-Fluorouracil|[[results:exp1|exp1 (2µM)]]\\ [[results:exp2|exp2 (20µM)]]|Thymidylate synthase inhibitor, blocks DNA replication|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Replication Inhibitor| | |5-Fluorouracil|[[results:exp1|exp1 (2µM)]]\\ [[results:exp2|exp2 (20µM)]]|Thymidylate synthase inhibitor, blocks DNA replication|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Replication Inhibitor| |
| |Actinomycin D|[[results:exp3|exp3 (1nM)]]\\ [[results:exp4|exp4 (10nM)]]|Inhibits RNA polymerases, intercalates DNA, prevents chain elongation|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor| | |Actinomycin D|[[results:exp3|exp3 (1nM)]]\\ [[results:exp4|exp4 (10nM)]]|Inhibits RNA polymerases, intercalates DNA, prevents chain elongation|**Class / Subclass 1: ** Gene Regulation / Transcription Inhibitor| |
| |UM0131023|[[results:exp248|exp248 (50nM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit| | |UM0131023|[[results:exp248|exp248 (50nM)]]|Unknown|**Class / Subclass 1: ** Uncharacterized Mechanism / Chemical Screen Hit| |
| |Vinorelbine|[[results:exp249|exp249 (1nM)]]|Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC)|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor| | |Vinorelbine|[[results:exp249|exp249 (1nM)]]|Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC)|**Class / Subclass 1: ** Cell Cycle / Microtubule Poison\\ **Class / Subclass 2: ** Organelle Function / Cytoskeletal Inhibitor| |
| |6-Thioguanine|[[results:exp259|exp259 (2µM)]]|Nucleoside analog, incorporated into telomeric DNA by telomerase, impairs proliferation of telomerase-positive cells|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Helix-Distorting Adduct| | |6-Thio-2'-deoxyguanosine|[[results:exp259|exp259 (2µM)]]|Nucleoside analog, incorporated into telomeric DNA by telomerase, impairs proliferation of telomerase-positive cells|**Class / Subclass 1: ** Metabolism / Antimetabolite\\ **Class / Subclass 2: ** DNA Damage, Repair and Replication / Helix-Distorting Adduct| |
| |ABT-702|[[results:exp320|exp320 (5µM + 18µM CoCl2)]]\\ [[results:exp318|exp318 (5µM)]]\\ [[results:exp321|exp321 (5µM + 11µM Deferoxamine)]]\\ [[results:exp319|exp319 (5µM + 11µM Dimethyloxaloylglycine)]]\\ [[results:exp260|exp260 (100nM)]]\\ [[results:exp261|exp261 (5µM)]]|Inhibits adenosine kinase (ADK)|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor| | |ABT-702|[[results:exp320|exp320 (5µM + 18µM CoCl2)]]\\ [[results:exp318|exp318 (5µM)]]\\ [[results:exp321|exp321 (5µM + 11µM Deferoxamine)]]\\ [[results:exp319|exp319 (5µM + 11µM Dimethyloxaloylglycine)]]\\ [[results:exp260|exp260 (100nM)]]\\ [[results:exp261|exp261 (5µM)]]|Inhibits adenosine kinase (ADK)|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Inhibitor| |
| |ALDA-1|[[results:exp262|exp262 (10µM)]]|Activates mitochondrial aldehyde dehydrogenase (ALDH2), may attenuate ethanol addiction|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Activator| | |ALDA-1|[[results:exp262|exp262 (10µM)]]|Activates mitochondrial aldehyde dehydrogenase (ALDH2), may attenuate ethanol addiction|**Class / Subclass 1: ** Metabolism / Metabolic Enzyme Activator| |