A1CF [The Human Chemical-Genetic Interaction Map Project]

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======= A1CF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: A1CF
  * **<color #00a2e8>Official Name</color>**: APOBEC1 complementation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29974|29974]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQ94|Q9NQ94]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=A1CF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20A1CF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618199|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|apolipoprotein B mRNA editing enzyme complex|
|mRNA localization resulting in posttranscriptional regulation of gene expression|
|intracellular mRNA localization|
|cytidine to uridine editing|
|base conversion or substitution editing|
|mRNA modification|
|single-stranded RNA binding|
|double-stranded RNA binding|
|mRNA binding|
|RNA modification|
|protein stabilization|
|RNA localization|
|regulation of protein stability|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|RNA processing|
|endoplasmic reticulum|
|RNA binding|
|cellular macromolecule localization|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.13|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.95|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.85|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.7|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6771
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='A1CF Expression in NALM6 Cells: 1.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>