ABAT [The Human Chemical-Genetic Interaction Map Project]

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======= ABAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABAT
  * **<color #00a2e8>Official Name</color>**: 4-aminobutyrate aminotransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=18|18]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P80404|P80404]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aminotran 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of aspartate secretion|
|negative regulation of gamma-aminobutyric acid secretion|
|(S)-3-amino-2-methylpropionate transaminase activity|
|4-aminobutyrate transaminase activity|
|regulation of aspartate secretion|
|4-aminobutyrate transaminase complex|
|succinate-semialdehyde dehydrogenase binding|
|4-aminobutyrate:2-oxoglutarate transaminase activity|
|gamma-aminobutyric acid catabolic process|
|negative regulation of dopamine secretion|
|positive regulation of prolactin secretion|
|gamma-aminobutyric acid biosynthetic process|
|gamma-aminobutyric acid metabolic process|
|positive regulation of dopamine metabolic process|
|regulation of gamma-aminobutyric acid secretion|
|positive regulation of catecholamine metabolic process|
|modulation of inhibitory postsynaptic potential|
|positive regulation of uterine smooth muscle contraction|
|positive regulation of inhibitory postsynaptic potential|
|iron-sulfur cluster binding|
|positive regulation of cellular amine metabolic process|
|negative regulation of amino acid transport|
|regulation of uterine smooth muscle contraction|
|positive regulation of heat generation|
|negative regulation of platelet aggregation|
|regulation of heat generation|
|negative regulation of catecholamine secretion|
|negative regulation of homotypic cell-cell adhesion|
|copulation|
|positive regulation of amino acid transport|
|regulation of platelet aggregation|
|negative regulation of platelet activation|
|behavioral response to cocaine|
|regulation of catecholamine metabolic process|
|regulation of dopamine metabolic process|
|negative regulation of organic acid transport|
|neurotransmitter catabolic process|
|negative regulation of neurotransmitter transport|
|regulation of homotypic cell-cell adhesion|
|negative regulation of amine transport|
|exploration behavior|
|negative regulation of response to drug|
|negative regulation of anion transport|
|positive regulation of smooth muscle contraction|
|regulation of platelet activation|
|regulation of amino acid transport|
|mating|
|response to iron ion|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|regulation of dopamine secretion|
|neurotransmitter biosynthetic process|
|positive regulation of muscle contraction|
|negative regulation of blood pressure|
|response to nicotine|
|positive regulation of anion transport|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|pyridoxal phosphate binding|
|response to cocaine|
|regulation of organic acid transport|
|regulation of smooth muscle contraction|
|regulation of catecholamine secretion|
|positive regulation of nervous system process|
|negative regulation of wound healing|
|positive regulation of insulin secretion|
|response to anesthetic|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of cellular amine metabolic process|
|regulation of coagulation|
|cellular amino acid biosynthetic process|
|negative regulation of response to wounding|
|neurotransmitter metabolic process|
|regulation of amine transport|
|regulation of anion transport|
|positive regulation of peptide hormone secretion|
|regulation of response to drug|
|cerebellum development|
|metencephalon development|
|response to alkaloid|
|monocarboxylic acid catabolic process|
|cellular amino acid catabolic process|
|response to ethanol|
|positive regulation of hormone secretion|
|regulation of nervous system process|
|regulation of wound healing|
|regulation of neurotransmitter transport|
|adult behavior|
|negative regulation of ion transport|
|positive regulation of synaptic transmission|
|hindbrain development|
|regulation of muscle contraction|
|regulation of response to wounding|
|negative regulation of cell-cell adhesion|
|regulation of insulin secretion|
|regulation of blood pressure|
|response to ammonium ion|
|monocarboxylic acid biosynthetic process|
|locomotory behavior|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|negative regulation of secretion|
|response to alcohol|
|regulation of muscle system process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|positive regulation of ion transport|
|aging|
|positive regulation of peptide secretion|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|response to antibiotic|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|neuron projection|
|response to hypoxia|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|mitochondrial matrix|
|response to metal ion|
|response to oxygen levels|
|blood circulation|
|circulatory system process|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of membrane potential|
|positive regulation of secretion|
|small molecule catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|response to inorganic substance|
|behavior|
|regulation of system process|
|small molecule biosynthetic process|
|regulation of cell activation|
|regulation of cell adhesion|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|sexual reproduction|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|central nervous system development|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of response to stress|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.83|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9916
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABAT Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>