ABCA12 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCA12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCA12
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily A member 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26154|26154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UK0|Q86UK0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCA12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCA12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607800|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transporter involved in lipid homeostasis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC2 membrane 3|
|ABC tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase-coupled lipid transmembrane transporter activity|
|apolipoprotein A-I receptor binding|
|epidermal lamellar body|
|surfactant homeostasis|
|phospholipid efflux|
|chemical homeostasis within a tissue|
|ceramide transport|
|positive regulation of cholesterol efflux|
|positive regulation of protein localization to cell surface|
|establishment of skin barrier|
|regulation of cholesterol efflux|
|positive regulation of cholesterol transport|
|positive regulation of sterol transport|
|regulation of water loss via skin|
|lipid transporter activity|
|regulation of protein localization to cell surface|
|lung alveolus development|
|regulation of cholesterol transport|
|regulation of sterol transport|
|ATPase-coupled transmembrane transporter activity|
|positive regulation of lipid transport|
|multicellular organismal water homeostasis|
|water homeostasis|
|positive regulation of lipid localization|
|phospholipid transport|
|regulation of lipid transport|
|organophosphate ester transport|
|lipid homeostasis|
|regulation of lipid localization|
|lung development|
|respiratory tube development|
|protein localization to plasma membrane|
|tissue homeostasis|
|respiratory system development|
|keratinization|
|protein localization to cell periphery|
|ATPase activity|
|keratinocyte differentiation|
|lipid transport|
|epidermal cell differentiation|
|lipid localization|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|signaling receptor binding|
|anatomical structure homeostasis|
|skin development|
|epidermis development|
|organic anion transport|
|protein localization to membrane|
|regulation of body fluid levels|
|regulation of cellular protein localization|
|anion transport|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|exocytosis|
|tube development|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|chemical homeostasis|
|epithelium development|
|secretion|
|transmembrane transport|
|ion transport|
|ATP binding|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|tissue development|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCA12 Expression in NALM6 Cells: 0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>