ABCA7 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCA7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCA7
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily A member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10347|10347]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZY2|Q8IZY2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCA7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCA7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605414|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC tran|
|ABC2 membrane 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of engulfment of apoptotic cell|
|apolipoprotein A-I receptor activity|
|phosphatidylserine floppase activity|
|positive regulation of phospholipid efflux|
|regulation of phospholipid efflux|
|regulation of engulfment of apoptotic cell|
|phosphatidylcholine floppase activity|
|apolipoprotein A-I-mediated signaling pathway|
|amyloid-beta formation|
|negative regulation of amyloid precursor protein biosynthetic process|
|positive regulation of amyloid-beta clearance|
|amyloid-beta clearance by cellular catabolic process|
|positive regulation of apoptotic cell clearance|
|plasma membrane raft organization|
|regulation of phospholipid transport|
|positive regulation of phospholipid transport|
|regulation of apoptotic cell clearance|
|glial cell projection|
|amyloid precursor protein catabolic process|
|phospholipid efflux|
|positive regulation of membrane invagination|
|regulation of amyloid precursor protein biosynthetic process|
|negative regulation of glycoprotein biosynthetic process|
|high-density lipoprotein particle assembly|
|negative regulation of amyloid-beta formation|
|positive regulation of phagocytosis, engulfment|
|negative regulation of amyloid precursor protein catabolic process|
|regulation of phagocytosis, engulfment|
|positive regulation of cholesterol efflux|
|negative regulation of glycoprotein metabolic process|
|regulation of membrane invagination|
|regulation of amyloid-beta clearance|
|positive regulation of protein localization to cell surface|
|amyloid precursor protein metabolic process|
|amyloid-beta metabolic process|
|membrane raft organization|
|amyloid-beta clearance|
|regulation of cholesterol efflux|
|positive regulation of cholesterol transport|
|positive regulation of sterol transport|
|cholesterol efflux|
|plasma lipoprotein particle assembly|
|regulation of amyloid-beta formation|
|phagocytic cup|
|lipid transporter activity|
|protein-lipid complex assembly|
|regulation of amyloid precursor protein catabolic process|
|regulation of protein localization to cell surface|
|regulation of glycoprotein biosynthetic process|
|phospholipid translocation|
|lipid translocation|
|negative regulation of endocytosis|
|plasma lipoprotein particle organization|
|regulation of cholesterol transport|
|regulation of glycoprotein metabolic process|
|regulation of sterol transport|
|protein-lipid complex subunit organization|
|positive regulation of anion transport|
|regulation of membrane lipid distribution|
|ATPase-coupled transmembrane transporter activity|
|cholesterol transport|
|peptide cross-linking|
|positive regulation of lipid transport|
|sterol transport|
|positive regulation of phagocytosis|
|regulation of plasma lipoprotein particle levels|
|positive regulation of lipid localization|
|phospholipid transport|
|plasma membrane organization|
|regulation of anion transport|
|regulation of phagocytosis|
|ruffle membrane|
|positive regulation of endocytosis|
|regulation of lipid transport|
|memory|
|organophosphate ester transport|
|organic hydroxy compound transport|
|regulation of lipid localization|
|negative regulation of cellular amide metabolic process|
|early endosome membrane|
|protein localization to nucleus|
|regulation of endocytosis|
|positive regulation of ERK1 and ERK2 cascade|
|ATPase activity|
|learning or memory|
|positive regulation of ion transport|
|regulation of ERK1 and ERK2 cascade|
|lipid transport|
|cognition|
|lipid localization|
|positive regulation of cellular protein localization|
|phagocytosis|
|extracellular structure organization|
|regulation of cellular amide metabolic process|
|endomembrane system organization|
|organic anion transport|
|negative regulation of transport|
|peptide metabolic process|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|cell junction|
|regulation of vesicle-mediated transport|
|behavior|
|anion transport|
|cell surface|
|Golgi membrane|
|intracellular membrane-bounded organelle|
|regulation of ion transport|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of MAPK cascade|
|cellular amide metabolic process|
|membrane organization|
|regulation of cellular localization|
|ion transmembrane transport|
|Golgi apparatus|
|positive regulation of transport|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|transmembrane transport|
|ion transport|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.44|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4755
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCA7 Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>