ABCB1 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCB1
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5243|5243]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08183|P08183]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/171050|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC ATPase|
|ABC membrane|
|ABC tran|
|SMC N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ceramide floppase activity|
|ceramide translocation|
|phosphatidylethanolamine flippase activity|
|sphingolipid translocation|
|ATPase-coupled xenobiotic transmembrane transporter activity|
|positive regulation of anion channel activity|
|phosphatidylcholine floppase activity|
|positive regulation of anion transmembrane transport|
|regulation of anion channel activity|
|regulation of chloride transport|
|regulation of response to osmotic stress|
|ceramide transport|
|regulation of anion transmembrane transport|
|transporter activity|
|phospholipid translocation|
|lipid translocation|
|positive regulation of anion transport|
|regulation of membrane lipid distribution|
|ATPase-coupled transmembrane transporter activity|
|stem cell proliferation|
|phospholipid transport|
|regulation of anion transport|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|organophosphate ester transport|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|positive regulation of ion transmembrane transport|
|positive regulation of transmembrane transport|
|ATPase activity|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|mitotic cell cycle phase transition|
|positive regulation of ion transport|
|regulation of transporter activity|
|cell cycle phase transition|
|lipid transport|
|apical plasma membrane|
|lipid localization|
|organic anion transport|
|regulation of ion transmembrane transport|
|cell population proliferation|
|regulation of transmembrane transport|
|anion transport|
|mitotic cell cycle process|
|cell surface|
|mitotic cell cycle|
|regulation of ion transport|
|membrane organization|
|ion transmembrane transport|
|positive regulation of transport|
|cell cycle process|
|response to drug|
|transmembrane transport|
|cell cycle|
|ion transport|
|regulation of response to stress|
|ATP binding|
|amide transport|
|positive regulation of molecular function|
|nitrogen compound transport|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.05|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.84|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7030
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCB1 Expression in NALM6 Cells: -1.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>