ABCC2 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCC2
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily C member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1244|1244]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92887|Q92887]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601107|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC tran|
|ABC membrane|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|benzylpenicillin metabolic process|
|mercury ion transport|
|beta-lactam antibiotic metabolic process|
|penicillin metabolic process|
|bilirubin transmembrane transporter activity|
|bilirubin transport|
|detoxification of mercury ion|
|cellular lactam metabolic process|
|ATPase-coupled xenobiotic transmembrane transporter activity|
|cellular chloride ion homeostasis|
|canalicular bile acid transport|
|response to methotrexate|
|intercellular canaliculus|
|prostaglandin transport|
|thyroid hormone transport|
|response to mercury ion|
|organic anion transmembrane transporter activity|
|cellular monovalent inorganic anion homeostasis|
|cellular anion homeostasis|
|chloride ion homeostasis|
|response to antimetabolite|
|detoxification of inorganic compound|
|monovalent inorganic anion homeostasis|
|bile acid and bile salt transport|
|cellular response to dexamethasone stimulus|
|icosanoid transport|
|fatty acid derivative transport|
|cellular response to interleukin-6|
|response to arsenic-containing substance|
|response to interleukin-6|
|response to glucagon|
|response to dexamethasone|
|ATPase-coupled transmembrane transporter activity|
|brush border membrane|
|secondary metabolic process|
|cellular response to glucocorticoid stimulus|
|cellular amine metabolic process|
|anion homeostasis|
|cellular response to corticosteroid stimulus|
|amine metabolic process|
|drug transmembrane transport|
|fatty acid transport|
|response to estrogen|
|dicarboxylic acid transport|
|acid secretion|
|hormone transport|
|cellular response to ketone|
|response to antineoplastic agent|
|antibiotic metabolic process|
|response to heat|
|transition metal ion transport|
|detoxification|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|response to glucocorticoid|
|drug transport|
|response to corticosteroid|
|cellular response to interleukin-1|
|response to temperature stimulus|
|female pregnancy|
|cellular response to lipopolysaccharide|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|cellular response to molecule of bacterial origin|
|response to ketone|
|response to interleukin-1|
|multi-multicellular organism process|
|cellular response to biotic stimulus|
|ATPase activity|
|cellular response to tumor necrosis factor|
|protein domain specific binding|
|response to tumor necrosis factor|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|response to lipopolysaccharide|
|apical plasma membrane|
|lipid localization|
|response to molecule of bacterial origin|
|response to steroid hormone|
|response to acid chemical|
|sulfur compound metabolic process|
|response to metal ion|
|response to oxidative stress|
|response to peptide hormone|
|cellular response to drug|
|organic anion transport|
|response to peptide|
|drug metabolic process|
|response to toxic substance|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|anion transport|
|cellular response to hormone stimulus|
|cell surface|
|metal ion transport|
|cellular ion homeostasis|
|response to bacterium|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|cellular amide metabolic process|
|ion homeostasis|
|cation transport|
|response to lipid|
|cellular homeostasis|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|secretion|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.96|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.8|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.8|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11213
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCC2 Expression in NALM6 Cells: 2.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>