ABCC4 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCC4
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily C member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10257|10257]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15439|O15439]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be an organic anion pump relevant to cellular detoxification.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC tran|
|ABC membrane|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ion transmembrane transporter activity, phosphorylative mechanism|
|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|
|prostaglandin secretion|
|platelet dense granule membrane|
|prostaglandin transport|
|icosanoid secretion|
|fatty acid derivative transport|
|icosanoid transport|
|ATPase-coupled transmembrane transporter activity|
|fatty acid transport|
|acid secretion|
|positive regulation of smooth muscle cell proliferation|
|platelet degranulation|
|regulation of smooth muscle cell proliferation|
|monocarboxylic acid transport|
|basolateral plasma membrane|
|ATPase activity|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|lipid localization|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|organic anion transport|
|anion transport|
|regulated exocytosis|
|organelle assembly|
|exocytosis|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|ion transmembrane transport|
|oxidation-reduction process|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|response to nitrogen compound|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|transmembrane transport|
|ion transport|
|ATP binding|
|regulation of cell population proliferation|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-5.44|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-4.25|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-3.24|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.48|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.05|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.79|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.76|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.71|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.84|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|8.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16330
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCC4 Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>