ABCD2 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCD2
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily D member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=225|225]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBJ2|Q9UBJ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601081|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transporter.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC membrane 2|
|ABC tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|very long-chain fatty acid catabolic process|
|positive regulation of unsaturated fatty acid biosynthetic process|
|neuron projection maintenance|
|positive regulation of fatty acid beta-oxidation|
|regulation of unsaturated fatty acid biosynthetic process|
|myelin maintenance|
|positive regulation of fatty acid oxidation|
|negative regulation of cytokine production involved in inflammatory response|
|regulation of fatty acid beta-oxidation|
|positive regulation of fatty acid biosynthetic process|
|positive regulation of lipid catabolic process|
|negative regulation of reactive oxygen species biosynthetic process|
|regulation of fatty acid oxidation|
|very long-chain fatty acid metabolic process|
|positive regulation of fatty acid metabolic process|
|regulation of cytokine production involved in inflammatory response|
|neuron projection organization|
|regulation of fatty acid biosynthetic process|
|ATPase-coupled transmembrane transporter activity|
|negative regulation of reactive oxygen species metabolic process|
|regulation of lipid catabolic process|
|peroxisomal membrane|
|fatty acid beta-oxidation|
|fatty acid oxidation|
|lipid oxidation|
|positive regulation of lipid biosynthetic process|
|regulation of reactive oxygen species biosynthetic process|
|regulation of fatty acid metabolic process|
|plasma membrane organization|
|fatty acid catabolic process|
|myelination|
|peroxisome|
|ensheathment of neurons|
|axon ensheathment|
|monocarboxylic acid catabolic process|
|negative regulation of inflammatory response|
|positive regulation of small molecule metabolic process|
|positive regulation of lipid metabolic process|
|regulation of cellular ketone metabolic process|
|regulation of reactive oxygen species metabolic process|
|regulation of lipid biosynthetic process|
|cellular lipid catabolic process|
|lipid modification|
|negative regulation of defense response|
|ATPase activity|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|negative regulation of cytokine production|
|lipid catabolic process|
|fatty acid metabolic process|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|positive regulation of cellular catabolic process|
|regulation of lipid metabolic process|
|endomembrane system organization|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|regulation of cytokine production|
|regulation of defense response|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|cellular lipid metabolic process|
|oxidation-reduction process|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|transmembrane transport|
|ion transport|
|regulation of response to stress|
|ATP binding|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.71|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16766
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCD2 Expression in NALM6 Cells: -1.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>