ABCF3 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCF3
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily F member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55324|55324]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NUQ8|Q9NUQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618967|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. The protein encoded by this gene displays antiviral effect against flaviviruses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC tran|
|ABC tran 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|defense response to virus|
|ATPase activity|
|response to virus|
|cadherin binding|
|defense response to other organism|
|immune effector process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ATP binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.16|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.03|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.01|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.99|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.97|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.9|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.9|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.89|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.84|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.82|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.75|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.73|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.78|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.81|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.84|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.03|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.16|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.38|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nxt1|NXT1]]|0.533|
|[[:human genes:e:eny2|ENY2]]|0.448|
|[[:human genes:h:hars|HARS]]|0.437|
|[[:human genes:c:csk|CSK]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8037
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCF3 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>