ABCG2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ABCG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCG2
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily G member 2 (Junior blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9429|9429]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNQ0|Q9UNQ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603756|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC2 membrane 3|
|ABC2 membrane|
|ABC tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase-coupled xenobiotic transmembrane transporter activity|
|urate metabolic process|
|ATPase-coupled transmembrane transporter activity|
|cellular iron ion homeostasis|
|iron ion homeostasis|
|cellular detoxification|
|mitochondrial membrane|
|cellular transition metal ion homeostasis|
|detoxification|
|transition metal ion homeostasis|
|cellular response to toxic substance|
|ATPase activity|
|purine-containing compound metabolic process|
|response to toxic substance|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|protein homodimerization activity|
|cellular homeostasis|
|ion transmembrane transport|
|organic acid metabolic process|
|identical protein binding|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|ATP binding|
|homeostatic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-5.32|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-5.22|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-4.88|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-4.88|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-4.83|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-3.11|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.94|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.23|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.85|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.74|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10112
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCG2 Expression in NALM6 Cells: 3.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>