ABHD11 [The Human Chemical-Genetic Interaction Map Project]

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======= ABHD11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABHD11
  * **<color #00a2e8>Official Name</color>**: abhydrolase domain containing 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83451|83451]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFV4|Q8NFV4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABHD11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABHD11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621050|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thioesterase|
|Abhydrolase 1|
|PGAP1|
|Abhydrolase 5|
|Abhydrolase 6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hydrolase activity|
|cellular component|
|molecular function|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.09|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.73|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.7|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.75|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.84|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.85|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.91|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.14|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.23|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:glrx5|GLRX5]]|0.498|
|[[:human genes:s:suclg1|SUCLG1]]|0.483|
|[[:human genes:i:iba57|IBA57]]|0.472|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.45|
|[[:human genes:g:got2|GOT2]]|0.421|
|[[:human genes:l:lipt2|LIPT2]]|0.42|
|[[:human genes:n:nans|NANS]]|0.415|
|[[:human genes:m:mrps36|MRPS36]]|0.41|
|[[:human genes:s:sucla2|SUCLA2]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1715
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABHD11 Expression in NALM6 Cells: 3.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>