ABI1 [The Human Chemical-Genetic Interaction Map Project]

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======= ABI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABI1
  * **<color #00a2e8>Official Name</color>**: abl interactor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10006|10006]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZP0|Q8IZP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603050|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|Abi HHR|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lamellipodium morphogenesis|
|SCAR complex|
|protein tyrosine kinase activator activity|
|megakaryocyte development|
|filopodium tip|
|megakaryocyte differentiation|
|bone cell development|
|lamellipodium organization|
|actin polymerization or depolymerization|
|positive regulation of protein tyrosine kinase activity|
|dendrite morphogenesis|
|myeloid cell development|
|somitogenesis|
|vascular endothelial growth factor receptor signaling pathway|
|cytoskeletal protein binding|
|somite development|
|intracellular|
|regulation of protein tyrosine kinase activity|
|segmentation|
|dendrite development|
|growth cone|
|SH3 domain binding|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|lamellipodium|
|positive regulation of peptidyl-tyrosine phosphorylation|
|bone development|
|postsynaptic membrane|
|anterior/posterior pattern specification|
|myeloid cell differentiation|
|actin filament organization|
|Fc receptor signaling pathway|
|postsynaptic density|
|regulation of peptidyl-tyrosine phosphorylation|
|cadherin binding|
|phagocytosis|
|regionalization|
|cytoskeleton|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|immune response-activating cell surface receptor signaling pathway|
|supramolecular fiber organization|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|skeletal system development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|positive regulation of protein kinase activity|
|cell junction|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|immune response-activating signal transduction|
|actin filament-based process|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|positive regulation of transferase activity|
|neuron projection development|
|negative regulation of cell population proliferation|
|viral process|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|symbiotic process|
|regulation of protein kinase activity|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|positive regulation of immune response|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|endoplasmic reticulum|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|immune effector process|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.96|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.89|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9206
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABI1 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>