ABL2 [The Human Chemical-Genetic Interaction Map Project]

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======= ABL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABL2
  * **<color #00a2e8>Official Name</color>**: ABL proto-oncogene 2, non-receptor tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27|27]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42684|P42684]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F actin bind|
|SH3 2|
|SH3 1|
|Pkinase|
|Pkinase Tyr|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Rho protein signal transduction|
|exploration behavior|
|actin monomer binding|
|peptidyl-tyrosine autophosphorylation|
|regulation of actin cytoskeleton reorganization|
|phosphotyrosine residue binding|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|non-membrane spanning protein tyrosine kinase activity|
|negative regulation of Ras protein signal transduction|
|positive regulation of oxidoreductase activity|
|positive regulation of phospholipase activity|
|negative regulation of small GTPase mediated signal transduction|
|manganese ion binding|
|cellular response to retinoic acid|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|protein tyrosine kinase activity|
|regulation of oxidoreductase activity|
|regulation of lipase activity|
|response to retinoic acid|
|regulation of Rho protein signal transduction|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|protein autophosphorylation|
|actin filament binding|
|regulation of endocytosis|
|cellular response to acid chemical|
|magnesium ion binding|
|actin cytoskeleton|
|protein kinase activity|
|regulation of Ras protein signal transduction|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|regulation of autophagy|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|response to acid chemical|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|divalent inorganic cation homeostasis|
|regulation of neuron projection development|
|negative regulation of intracellular signal transduction|
|cellular response to lipid|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|behavior|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|response to lipid|
|peptidyl-amino acid modification|
|cellular homeostasis|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of locomotion|
|regulation of catabolic process|
|regulation of cellular component movement|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|ATP binding|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.74|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.74|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17091
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABL2 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>