ACAA1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ACAA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACAA1
  * **<color #00a2e8>Official Name</color>**: acetyl-CoA acyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30|30]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09110|P09110]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACAA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACAA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604054|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thiolase N|
|Thiolase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetate CoA-transferase activity|
|auxin catabolic process|
|phenylacetate catabolic process|
|auxin metabolic process|
|palmitoyl-CoA oxidase activity|
|toxin catabolic process|
|acetyl-CoA C-acyltransferase activity|
|xenobiotic catabolic process|
|alpha-linolenic acid metabolic process|
|fatty acid beta-oxidation using acyl-CoA oxidase|
|hormone catabolic process|
|toxin metabolic process|
|benzene-containing compound metabolic process|
|very long-chain fatty acid metabolic process|
|bile acid metabolic process|
|peroxisomal matrix|
|secondary metabolic process|
|fatty acid beta-oxidation|
|specific granule lumen|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|fatty acid oxidation|
|lipid oxidation|
|peroxisome organization|
|fatty acid catabolic process|
|unsaturated fatty acid metabolic process|
|peroxisome|
|long-chain fatty acid metabolic process|
|monocarboxylic acid catabolic process|
|detoxification|
|xenobiotic metabolic process|
|cellular response to xenobiotic stimulus|
|cellular lipid catabolic process|
|lipid modification|
|hormone metabolic process|
|steroid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|response to xenobiotic stimulus|
|fatty acid metabolic process|
|protein targeting|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|protein localization to organelle|
|leukocyte mediated immunity|
|exocytosis|
|carboxylic acid metabolic process|
|leukocyte activation|
|cellular lipid metabolic process|
|oxidation-reduction process|
|intracellular protein transport|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|lipid metabolic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.72|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.76|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.79|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.94|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:acsl3|ACSL3]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13118
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACAA1 Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>