ACAA2 [The Human Chemical-Genetic Interaction Map Project]

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======= ACAA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACAA2
  * **<color #00a2e8>Official Name</color>**: acetyl-CoA acyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10449|10449]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42765|P42765]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACAA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACAA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Abolishes BNIP3-mediated apoptosis and mitochondrial damage. {ECO:0000269|PubMed:18371312}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thiolase C|
|Thiolase N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitochondrial membrane permeability involved in apoptotic process|
|acetyl-CoA C-acetyltransferase activity|
|acetyl-CoA C-acyltransferase activity|
|acetyl-CoA hydrolase activity|
|negative regulation of mitochondrial membrane permeability|
|negative regulation of membrane permeability|
|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|myristoyl-CoA hydrolase activity|
|palmitoyl-CoA hydrolase activity|
|acyl-CoA hydrolase activity|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|sterol biosynthetic process|
|negative regulation of mitochondrion organization|
|fatty acid beta-oxidation|
|apoptotic mitochondrial changes|
|regulation of mitochondrial membrane permeability|
|fatty acid oxidation|
|lipid oxidation|
|regulation of membrane permeability|
|fatty acid catabolic process|
|alcohol biosynthetic process|
|cholesterol metabolic process|
|monocarboxylic acid catabolic process|
|steroid biosynthetic process|
|mitochondrial membrane organization|
|secondary alcohol metabolic process|
|sterol metabolic process|
|regulation of mitochondrion organization|
|organic hydroxy compound biosynthetic process|
|cellular response to hypoxia|
|cellular lipid catabolic process|
|cellular response to decreased oxygen levels|
|lipid modification|
|cellular response to oxygen levels|
|mitochondrial transport|
|negative regulation of apoptotic signaling pathway|
|steroid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|lipid catabolic process|
|alcohol metabolic process|
|fatty acid metabolic process|
|response to hypoxia|
|response to decreased oxygen levels|
|mitochondrial matrix|
|negative regulation of organelle organization|
|response to oxygen levels|
|regulation of apoptotic signaling pathway|
|small molecule catabolic process|
|mitochondrion organization|
|organic hydroxy compound metabolic process|
|negative regulation of transport|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|negative regulation of cellular component organization|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|apoptotic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|programmed cell death|
|cell death|
|response to abiotic stimulus|
|lipid metabolic process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|RNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17326
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACAA2 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>